Magnetic nanoformulations for prostate cancer

Chowdhury, Pallabita; Roberts, Allison M.; Khan, Sheema; Hafeez, Bilal Bin; Chauhan, Subhash C.; Jaggi, Meena; Yallapu, Murali M.

doi:10.1016/j.drudis.2017.04.018

Cited by 22 publications

(6 citation statements)

References 86 publications

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“…MNPs can convert their energy to heat under the influence of an alternating magnetic field. 13 The previous studies have shown that heat-induced MNPs encapsulated in liposomes can be a good option for magnetic thermotherapy. 6 , 24 , 28 The research in this field has investigated the effect of magnetic liposomes on the cancer treatment or drug loading on the liposome.…”

Section: Resultsmentioning

confidence: 99%

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

2022

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Purpose: Magnetic hyperthermia is a treatment method based on eddy currents, hysteresis, and relaxation mechanisms of magnetic nanoparticles (MNPs). MNPs such as Fe3O4 have the ability to generate heat under an alternating magnetic field. Heat sensitive liposomes (Lip) convert from lipid layer to liquid layer through heat generated by MNPs and can release drugs. In this research we explore whether combining liposomes, Doxorubicin (DOX) and Magnetic Nanoparticles could help magnetic hypothermia treatment be even more effective in treating cancerous tumors. Methods: In this study, different groups of DOX, MNPs and liposomes were evaluated. The superparamagnetic nano materials were synthesized by co-precipitation method. The MNPs, DOX and a combination of MNPs and DOX were efficiently loaded into the liposomes using the evaporator rotary technique. Magnetic properties, microstructure, specific absorption rate in MNPs, zeta potential, loading percentage of the MNPs and DOX concentration in liposomes, in vitro drug release of liposomes were studied. Finally, the necrosis percentage of cancer cells in C57BL/6J mice bearing melanoma tumors was assessed for all groups. Results: The loading percentages of MNPs and concentration of DOX in the liposomes were 18.52 and 65% respectively. The average size of Lip-DOX-MNPs obtained was 460 nm. The Lip-DOX-MNPs at the buffer citrate solution, showed highly specific absorption rate as the solution temperature reached 42°C in 5 min after exposure to alternative magnetic field. The release of DOX occurred in a pH-dependent manner. The volume of tumor in the therapeutic groups containing the MNPs significantly decreased compared to the others. Numerical analysis showed that the tumor volume in mice receiving Lip-MNPs-DOX was 9.29% that of the control and a histological examination of the tumor section showed 70% necrosis. Conclusion: The Lip-DOX-MNPs could be effective agents which reduce malignant skin tumors growth and increase cancer cell necrosis.

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Section: Resultsmentioning

confidence: 99%

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

2022

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“…An excellent review concerning the diagnosis, targeting, and treatment of prostate cancer by means of MNPs was published in 2017 by Chowdhury et al; the review concludes that modified MNPs that combine targeted drug delivery with MHT might represent potential future theranostic solutions for prostate cancer. Most importantly, these theranostic nanoformulations might allow the monitorization of disease progression while the treatment is ongoing based on the “see-and-treat” principle (Chowdhury et al 2017 ).…”

Section: Magnetic Nanoparticle Nanoformulations Biocompatibilitymentioning

confidence: 99%

Magnetic Nanoparticle Nanoformulations for Alternative Therapy of Cancer by Magnetic/Superparamagnetic Hyperthermia

Caizer

Dehelean

Coricovac

et al. 2020

Nanoformulations in Human Health

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Superparamagnetic hyperthermia, obtained by increasing the temperature to 42–43 °C in tumor tissue where magnetic nanoparticles are found, as a result of superparamagnetic relaxation, following the application of an external alternating magnetic field at a frequency of hundreds of kiloherz, is an alternative method that is noninvasive and apparently lacking toxicity and that has real potential as a cancer therapy. However, magnetic nanoparticles used as thermal mediators play a very important role in the efficacy of the method in the irreversible destruction of tumors. The NPs must meet a number of physical and magnetic characteristics in order to obtain the maximum hyperthermal effect, but also a reduced or even lack of toxicity on healthy cells. This chapter presents just this aspect of biocompatibility/cytotoxicity and nanoformulations of magnetic nanoparticles for their use in superparamagnetic hyperthermia. We will consider the recent nanoformulations that could be used successfully in superparamagnetic hyperthermia, tested in vitro and in vivo, as well as current trends in dual therapy, thermochemotherapy, or thermo-radiotherapy.

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“…Throughout the years, different types of nanosystems have been addressed in order to study their various biological applications and have a better understanding on which particles serve the human kind best in terms of serious diseases such as cancer [ 15 ]. Regarding the enhancement of PCa diagnosis and treatment, among the different types of nanoparticles studied so far are iron oxide, silver, gold, platinum, quantum dots, and liposomes [ 23 , 24 , 25 ]. The main challenges in the methods using the above-mentioned nanoparticles are to overcome their limited biodistribution, toxicity, and clearance from the excretory pathway [ 13 ] that is depicted in Table 1 .…”

Section: Nanotechnology and Its Importance In Theranosticsmentioning

confidence: 99%

Jumping on the Bandwagon: A Review on the Versatile Applications of Gold Nanostructures in Prostate Cancer

Sarkis

Ghanem

Rahme

2019

IJMS

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Prostate cancer (PCa) has remarkably emerged as a prominent disease in the face of the male population. Conventional treatments like prostatectomy or radiation can be curative only if PCa is diagnosed at an early stage. In the field of targeted therapy, a bevy of novel therapeutic approaches have left a landmark in PCa treatment and have proven to extend survival via distinct modes of actions. Nanotherapy has started to take root and has become the hype of the century by virtue of its abundant advantages. Scientists have invested a great deal of interest in the development of nanostructures such as gold nanoparticles (AuNPs), which hold particularly great hope for PCa theranostics. In this article, we present an overview of the studies published after 1998 that involve the use of different functionalized AuNPs to treat and diagnose PCa. Special reference is given to various in vitro and in vivo methods employed to shuttle AuNPs to PCa cells. Major studies show an enhancement of either detection or treatment of PCa when compared to their non-targeted counterparts, especially when AuNPs are tagged with specific ligands, such as antibodies, tea natural extracts, folate, anisamide, receptor inhibitors, and chitosan. Future approaches of treatment are dependent on those worthy multifunctional molecules, and are dictated by their ability to achieve a more versatile cancer therapeutic approach.

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Magnetic nanoformulations for prostate cancer

Cited by 22 publications

References 86 publications

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

Liposome-Fe3 O4-Doxorubicin Mediated Treatment of Melanoma Tumors

Magnetic Nanoparticle Nanoformulations for Alternative Therapy of Cancer by Magnetic/Superparamagnetic Hyperthermia

Jumping on the Bandwagon: A Review on the Versatile Applications of Gold Nanostructures in Prostate Cancer

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