Magnetic nanocarriers adorned on graphene: promising contrast-enhancing agents with state-of-the-art performance in magnetic resonance imaging (MRI) and theranostics

Gulati, Shikha; Mansi, Mansi; Vijayan, Sneha; Kumar, Sanjay; Agarwal, Varnika; Harikumar, Bharath; Varma, Rajender S.

doi:10.1039/d1ma01071a

Cited by 24 publications

(13 citation statements)

References 125 publications

(178 reference statements)

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“…Magnetic NPs (MNPs) have been studied as MRI nanoscale contrast agents and MNP-based targeted drug delivery for targeted cancer therapeutic and diagnostic applications, acting at the cellular and molecular levels due to their unique physicochemical characteristics . MNPs can be fabricated from cobalt metals, iron, as well as various cobalt alloys and iron oxides.…”

Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 99%

Advanced Nanosystems for Cancer Therapeutics: A Review

Mohajer

Mirhosseini‐Eshkevari

Ahmadi

et al. 2023

ACS Appl. Nano Mater.

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Since cancer has a very complex pathophysiology, existing cancer treatment strategies encounter several challenges such as the lack of specificity/selectivity, induction of multidrug resistance, and possible side effects/toxicity. A wide variety of organic, inorganic, and hybrid nanosystems have been designed with unique magnetic, thermal, mechanical, electrical, and optical properties for targeted cancer therapy. These advanced nanosystems with enhanced bioavailability, biocompatibility, and drug loading capacity have been developed for targeted cancer therapy to reduce toxicity and improve the targeting properties. In this context, challenges persist for their clinical translational studies and enhancement of their therapeutic efficiency as well as the optimization of synthesis conditions and large-scale production. In addition, despite promising preclinical results, the number of nanosystems available to patients is still very low, partly due to a lack of understanding of the differences among animal model species and humans that influence the behavior and functionality of these nanosystems. Regarding this, organ-on-a-chip platforms can significantly help in drug screening and delivery aspects in cancer/tumor cells as well as cancer modeling research; the organs-on-chip approach can also be helpful to analyze the cancer–immune cells interactions. Future studies should focus on the exploration of multifunctional nanosystems with synergistic chemo-photothermal, photothermal/photodynamic, and cancer immunotherapeutic potentials as well as smart nanosystems with theranostic capabilities. Herein, recent advancements pertaining to the applications of advanced nanosystems for cancer therapeutics are deliberated. Current obstacles and limitations hindering the application from research to clinical uses are also discussed while providing recommendations for a more efficient adoption of nanomaterials in the treatment of cancers.

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Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 99%

Advanced Nanosystems for Cancer Therapeutics: A Review

Mohajer

Mirhosseini‐Eshkevari

Ahmadi

et al. 2023

ACS Appl. Nano Mater.

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“…Graphene-related nanomaterial magnetic composites have a great advantage in helping these imaging guided therapy processes to improve the signals or contrasts to provide enhanced resolution in the final images during disease identification [ 99 ]. GO has been a scaffold for many imaging probes and drug loadings, and there are several works that have discussed magnetic nanoparticles-loaded GO, creating a better contrast agent due to its high loading capacity [ 100 ]. Recently, the oxidation of ball-milled graphite producing a nanoGO was reported.…”

Section: Graphene Nanocomposite Theranostics For Multimodal Imaging G...mentioning

confidence: 99%

“…In brief, many authors have reported that GO- and RGO-based iron oxide nanocomposites are excellent for MR imaging and guided therapy of cancer [ 100 ]. As discussed earlier, we also prepared an MFG-SiNC 4 with excellent superperamagnetic properties, fluorescence, biocompatibility, and water dispersability for in vitro MRI to serve as a good contrast agent, as shown in Figure 6 A,B.…”

Section: Graphene Nanocomposite Theranostics For Multimodal Imaging G...mentioning

confidence: 99%

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

2022

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The advancements in nanotechnology and nanomedicine are projected to solve many glitches in medicine, especially in the fields of cancer and infectious diseases, which are ranked in the top five most dangerous deadly diseases worldwide by the WHO. There is great concern to eradicate these problems with accurate diagnosis and therapies. Among many developed therapeutic models, near infra-red mediated phototherapy is a non-invasive technique used to invade many persistent tumors and bacterial infections with less inflammation compared with traditional therapeutic models such as radiation therapy, chemotherapy, and surgeries. Herein, we firstly summarize the up-to-date research on graphene phototheranostics for a better understanding of this field of research. We discuss the preparation and functionalization of graphene nanomaterials with various biocompatible components, such as metals, metal oxides, polymers, photosensitizers, and drugs, through covalent and noncovalent approaches. The multifunctional nanographene is used to diagnose the disease with confocal laser scanning microscopy, magnetic resonance imaging computed tomography, positron emission tomography, photoacoustic imaging, Raman, and ToF-SMIS to visualize inside the biological system for imaging-guided therapy are discussed. Further, treatment of disease by photothermal and photodynamic therapies against different cancers and bacterial infections are carefully conferred herein along with challenges and future perspectives.

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“…Metal−organic frameworks (MOFs), which consist of metal nodes and bridging ligands, are regarded as a kind of promising and tunable supports for different active sites to construct multifunctional catalysts because of their thermal/chemical stability, 11,17−20 adjustable porous frameworks, well-defined structures, 21,22 high density of uniformed catalytic sites, and crystalline nature for easily elucidating structure−function relationships. 23−25 Numerous MOF-based heterogeneous catalysts have been successfully synthesized and reported in the past decade via precisely introducing programmed catalytic sites into their frameworks.…”

Section: Introductionmentioning

confidence: 99%

CuCo Nanoparticle, Pd(II), and l-Proline Trifunctionalized UiO-67 Catalyst for Three-Step Sequential Asymmetric Reactions

Cheng

Ren

et al. 2023

Inorg. Chem.

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Metal−organic frameworks (MOFs) have become a promising support for different active sites to construct multifunctional and heterogeneous catalysts. However, the related investigation mainly focuses on introducing one or two active sites into MOFs and trifunctional catalysts have been very rarely reported. Herein, non-noble CuCo alloy nanoparticles, Pd 2+ , and L-proline, as encapsulated active species, functional organic linkers, and active metal nodes, respectively, were successfully decorated to UiO-67 to construct a chiral trifunctional catalyst by the one-step method, which was further applied to asymmetric three-step sequential oxidation of aromatic alcohols/Suzuki coupling/asymmetric aldol reactions with excellent oxidation and coupling performance (yields up to 95 and 96%, respectively), as well as good enantioselectivities (ee anti value up to 73%) in asymmetric aldol reactions. The heterogeneous catalyst can be reused at least five times without obvious deactivation due to the strong interaction between the MOFs and the active sites. This work provides an effective strategy to construct multifunctional catalysts via the introduction and combination of three or more of active sites, including encapsulated active species, functional organic linkers, and active metal nodes, into stable MOFs.

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Magnetic nanocarriers adorned on graphene: promising contrast-enhancing agents with state-of-the-art performance in magnetic resonance imaging (MRI) and theranostics

Abstract: Magnetic Resonance Imaging (MRI) is an effectual imaging technique for medical diagnosis, its non-invasive nature being a noteworthy attribute, where magnetic contrast agents are employed to improve sensitivity and accuracy....

Cited by 24 publications

References 125 publications

Advanced Nanosystems for Cancer Therapeutics: A Review

Advanced Nanosystems for Cancer Therapeutics: A Review

Multimodal Imaging and Phototherapy of Cancer and Bacterial Infection by Graphene and Related Nanocomposites

CuCo Nanoparticle, Pd(II), and l-Proline Trifunctionalized UiO-67 Catalyst for Three-Step Sequential Asymmetric Reactions

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