Magnetic Nanocarrier Containing 68Ga–DTPA Complex for Targeted Delivery of Doxorubicin

Pourmanouchehri, Zahra; Jafarzadeh, Mohammad; Kakaei, Saeed; Khameneh, Elham Sattarzadeh

doi:10.1007/s10904-018-0826-7

Cited by 11 publications

(4 citation statements)

References 39 publications

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“…To further study the peptide and organic content (peptide and APTES) (as the peptide amount on the SPIONs was determined via supernatant analysis after separation), TGA analysis was performed to assess the organic content of the SPIONs and the amount of remaining material after heating the peptide to 1000 °C (Figure 1B). As found in other studies, [22][23][24][25] After that, the weight is constant up to 1000 °C. For SPION-APTES and SPION-APTES-Pep the weight decreased corresponding to the loss of organic components on that particles.…”

Section: Characterisation Of Peptide Binding To Spion-aptessupporting

confidence: 77%

Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs

Friedrich¹,

Tietze²,

Dümig³

et al. 2023

IJN

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Purpose Magnetic separation of microbes can be an effective tool for pathogen identification and diagnostic applications to reduce the time needed for sample preparation. After peptide functionalization of superparamagnetic iron oxide nanoparticles (SPIONs) with an appropriate interface, they can be used for the separation of sepsis-associated yeasts like Candida albicans . Due to their magnetic properties, the magnetic extraction of the particles in the presence of an external magnetic field ensures the accumulation of the targeted yeast. Materials and Methods In this study, we used SPIONs coated with 3-aminopropyltriethoxysilane (APTES) and functionalized with a peptide originating from GP340 (SPION-APTES-Pep). For the first time, we investigate whether this system is suitable for the separation and enrichment of Candida albicans , we investigated its physicochemical properties and by thermogravimetric analysis we determined the amount of peptide on the SPIONs. Further, the toxicological profile was evaluated by recording cell cycle and DNA degradation. The separation efficiency was investigated using Candida albicans in different experimental settings, and regrowth experiments were carried out to show the use of SPION-APTES-Pep as a sample preparation method for the identification of fungal infections. Conclusion SPION-APTES-Pep can magnetically remove more than 80% of the microorganism and with a high selective host-pathogen distinction Candida albicans from water-based media and about 55% in blood after 8 minutes processing without compromising effects on the cell cycle of human blood cells. Moreover, the separated fungal cells could be regrown without any restrictions.

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Section: Characterisation Of Peptide Binding To Spion-aptessupporting

confidence: 77%

Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs

Friedrich¹,

Tietze²,

Dümig³

et al. 2023

IJN

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“…Pourmanouchehri et al functionalized Fe 3 O 4 @NH 2 -SiO 2 magnetic particles with diethylenetriaminepentaacetic acid (DTPA) with a double purpose: for complexing 68 Ga ions, acting as a positron emitting radionuclide, and for anchoring doxorubicin, a cancer chemotherapeutic drug, through the NH 2 pending moiety. 173 They reported that the amide bonds between the drug and the ligand could be cleaved to release the drug slowly over 4 hours in acidic pH, as cancerous cells typically have a low pH environment.…”

Section: Carboxylic Groups As a Ligand For Metal Ions And Charged Mol...mentioning

confidence: 99%

Revisiting carboxylic group functionalization of silica sol–gel materials

et al. 2023

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“…Uptake of drugs in magnetic drug delivery vehicles is carried out similar to non-magnetic carriers via conjugation (Chaudhary et al, 2015; Pourmanouchehri et al, 2018), hydrophobic interactions (Cho et al, 2018), absorption within porous structures (Kakar et al, 2013), etc. The drug release can be triggered by pH changes in the microenvironment (Wang et al, 2017; Wei et al, 2017; Wang, G. et al, 2018), by mechanical forces (Xu et al, 2018), NIR irradiation (Wang, Y. et al, 2018; Zheng et al, 2018), chemical reduction (Ao et al, 2018), HIFU (Moroz et al, 2001), and magnetic hyperthermia (Cho et al, 2018).…”

Section: Drug Uptake/releasementioning

confidence: 99%

Magnetic Drug Delivery: Where the Field Is Going

et al. 2018

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Targeted delivery of anticancer drugs is considered to be one of the pillars of cancer treatment as it could allow for a better treatment efficiency and less adverse effects. A promising drug delivery approach is magnetic drug targeting which can be realized if a drug delivery vehicle possesses a strong magnetic moment. Here, we discuss different types of magnetic nanomaterials which can be used as magnetic drug delivery vehicles, approaches to magnetic targeted delivery as well as promising strategies for the enhancement of the imaging-guided delivery and the therapeutic action.

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Magnetic Nanocarrier Containing 68Ga–DTPA Complex for Targeted Delivery of Doxorubicin

Cited by 11 publications

References 39 publications

Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs

Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs

Revisiting carboxylic group functionalization of silica sol–gel materials

Magnetic Drug Delivery: Where the Field Is Going

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