Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: MR Imaging and Brain Tumor Therapy

Ebrahimpour, Anita; Alam, Nader Riahi; Abdolmaleki, Parviz; Hajipour-Verdom, Behnam; Tirgar, Fatemeh; Ebrahimi, Tayyebeh; Khoobi, Mehdi

doi:10.1007/s10904-020-01782-5

Cited by 20 publications

(7 citation statements)

References 32 publications

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“…However, despite the mentioned issues, there is no doubt that MOFs still remain one of the most promising materials for cancer therapy due to their unique features including huge surface area, adjustable pore size, biocompatibility, biodegradability, and tunable composition. [ 19,217 ]…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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Recently, metal-organic frameworks (MOFs) have received a lot of interest for application in many fields ranging from catalysis, energy storage, and gas sensing to chemosensory and biomedicine owed to their flexible composition, tunable porosity, and easy functionalization ability. In particular, nanoscale MOFs have been broadly investigated as carriers for the delivery of therapeutics to cancerous organs owed to their high encapsulating capacity and controlled cargo release, versatility, biodegradability, and good biocompatibility.Several methods such as solvothermal, mechanochemical, electrochemical, microwave, and ultrasound have been utilized to fabricate MOFs via custommade synthesis. Many efforts have been made to functionalize MOFs through "post-synthetic modification," by adjusting the nature, size, and charge of the linkers or tuning its main components. Herein, a comprehensive literature review on recent papers dealing with drug-loaded MOFs for the detection and treatment of cancer as well as bacterial, fungal, and viral infections is presented. Different types of MOFs applied as carriers in drug delivery systems and biosensing platforms are described. Furthermore, perspectives and challenges for future research in the field, particularly for cancer therapy, are discussed. Thus, very limited literature is available on in vitro and in vivo toxicity of nanoscale MOFs. Besides, their biological stability and long-term safety are crucial factors that should be further investigated. Based on the reviewed papers, zeolite imidazolate framework (ZIF) and Materials of Institute Lavoisier (MIL) families have been the main focus for drug delivery and diagnosis applications, respectively, while many types of MOFs have exhibited antibacterial and antifungal properties regardless of their cargo.

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Section: Challenges and Opportunitiesmentioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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“…For instance, Khoobi et al. first prepared Fe 3 O 4 nanoparticles, which were then integrated within a MOF constructed from 5-aminolevulinic acid and zinc(II) ions during the MOF synthesis . The resulted particles were about 30 nm large and exhibited a high transverse relaxivity of 318 mM –1 s –1 (at 3.0 T).…”

Section: Mofs As Contrast Agents In Mrimentioning

confidence: 99%

Recent Advances in Metal–Organic Frameworks for Applications in Magnetic Resonance Imaging

Bunzen

Jirák

2022

ACS Appl. Mater. Interfaces

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Diagnostics is an important part of medical practice. The information required for diagnosis is typically collected by performing diagnostic tests, some of which include imaging. Magnetic resonance imaging (MRI) is one of the most widely used and effective imaging techniques. To improve the sensitivity and specificity of MRI, contrast agents are used. In this review, the usage of metal−organic frameworks (MOFs) and composite materials based on them as contrast agents for MRI is discussed. MOFs are crystalline porous coordination polymers. Due to their huge design variety and high density of metal ions, they have been studied as a highly promising class of materials for developing MRI contrast agents. This review highlights the most important studies and focuses on the progress of the field over the last five years. The materials are classified based on their design and structural properties into three groups: MRI-active MOFs, composite materials based on MOFs, and MRI-active compounds loaded in MOFs. Moreover, an overview of MOF-based materials for heteronuclear MRI including 129 Xe and 19 F MRI is given.

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“…This group of NMOFs can be distinguished based on its mechanism, which supports higher relaxivity and enhanced sensitivity in MRI with respect to unmodified magnetic (MOF-free) nanoparticles. There are several examples, including gold-incorporated MOFs for magnetic resonance imaging (MRI) and PTT for breast cancer treatment [ 78 ], target-specific anticancer ZIF-8/enzyme hybrid MOFs with minimal damage to the healthy cells [ 79 ], Fe 3 O 4 @bio-MOF-folic-acid-chitosan conjugate (FC) hybrid structures as theranostic in breast cancer [ 80 ], Zr-MOF@glucose-6-phosphate applied in kidney cancer treatment [ 81 ], highly selective and sensitive Cu-MOFs for liver cancer therapy [ 82 ], Fe 3 O 4 @nickel-cadmium quantum dots (QDs)/MOFs as a biosensor for prostate cancer diagnosis [ 83 ], and Fe 3 O 4 @5-aminolevulinic-acid-Zn MOF for MRI and brain tumor therapy [ 84 ]. There are also several disparate papers on the design, synthesis, and application of complex core-shell MOFs and flexible MOF-based theranostic nanoplatforms, mainly for multimodal imaging technologies.…”

Section: Multifunctional Mofs For Cancer Theranosticsmentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) for Cancer Therapy

et al. 2021

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MOFs exhibit inherent extraordinary features for diverse applications ranging from catalysis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in the MOFs, which are aimed at enlarging their applications window. Today’s knowledge of artificial intelligence and machine learning has opened new pathways to elaborate multiple nanoporous complex MOFs and nano-MOFs (NMOFs) for advanced theranostic, clinical, imaging, and diagnostic purposes. Successful accumulation of a photosensitizer in cancerous cells was a significant step in cancer therapy. The application of MOFs as advanced materials and systems for cancer therapy is the main scope beyond this perspective. Some challenging aspects and promising features in MOF-based cancer diagnosis and cancer therapy have also been discussed.

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Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: MR Imaging and Brain Tumor Therapy

Cited by 20 publications

References 32 publications

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Recent Advances in Metal–Organic Frameworks for Applications in Magnetic Resonance Imaging

Metal–Organic Frameworks (MOFs) for Cancer Therapy

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