Magnetic marker monitoring of disintegrating capsules

Weitschies, Werner; Karaus, M.; Cordini, Dino; Trahms, Lutz; Breitkreutz, Jörg; Semmler, Willi

doi:10.1016/s0928-0987(01)00140-3

Cited by 59 publications

(38 citation statements)

References 10 publications

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“…Compared with the results in [10], the localization error is decreased by about 3 mm. The trace of magnetically marked capsule was found to deviate by about 8 mm from the original pathway at capsule to sensor distances up to 250 mm [38]. In comparison with that, the location error is decreased by 6 mm; furthermore, the area within which the magnet moves is in 3-D. Fig.…”

Section: B Localization and Orientation Accuracy Of The Cubic Sensormentioning

confidence: 81%

A Cubic 3-Axis Magnetic Sensor Array for Wirelessly Tracking Magnet Position and Orientation

Song

et al. 2010

IEEE Sensors J.

190

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In medical diagnoses and treatments, e.g., endoscopy, dosage transition monitoring, it is often desirable to wirelessly track an object that moves through the human GI tract. In this paper, we propose a magnetic localization and orientation system for such applications. This system uses a small magnet enclosed in the object to serve as excitation source, so it does not require the connection wire and power supply for the excitation signal. When the magnet moves, it establishes a static magnetic field around, whose intensity is related to the magnet's position and orientation. With the magnetic sensors, the magnetic intensities in some predetermined spatial positions can be detected, and the magnet's position and orientation parameters can be computed based on an appropriate algorithm. Here, we propose a real-time tracking system developed by a cubic magnetic sensor array made of Honeywell 3-axis magnetic sensors, HMC1043. Using some efficient software modules and calibration methods, the system can achieve satisfactory tracking accuracy if the cubic sensor array has enough number of 3-axis magnetic sensors. The experimental results show that the average localization error is 1.8 mm.

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Section: B Localization and Orientation Accuracy Of The Cubic Sensormentioning

confidence: 81%

A Cubic 3-Axis Magnetic Sensor Array for Wirelessly Tracking Magnet Position and Orientation

Song

et al. 2010

IEEE Sensors J.

190

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“…Hard capsules can be labelled by addition of the magnetic material directly to the filling (15,97). Tablets can be labeled by addition of the magnetic material to the powder blend or by drilling a small hole to be filled with magnetic material (13,19).…”

Section: Magnetic Labeling Of Solid Dosage Formsmentioning

confidence: 99%

“…The disintegration process of tablets and capsules can be accurately determined in vitro (90,97). While the dosage form is characterized as a marker, the magnetic dipole moment remains stable; however, when the release of magnetic particles from the dosage forms occurs, those particles lose their orientation and do not generate a background signal; therefore, the time course of the magnetic moment is the direct measurement of disintegration (Fig.…”

Section: Magnetic Marker Monitoringmentioning

confidence: 99%

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Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

et al. 2010

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Biomagnetic methods have been designed for a wide range of applications. Recently, such methods have been proposed as alternatives to scintigraphy for evaluating of a number of pharmaceutical processes in vitro as well as under the influence of gastrointestinal physiological parameters. In this review, physical characterization as well as the most recent applications of Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) in the pharmaceutical research will be explored. Moreover, their current status and how these technologies can be employed to improve the knowledge about the impact of gastrointestinal physiology on drug delivery in association with pharmacokinetic outcomes, termed pharmacomagnetography, will be presented.

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“…Other workers have already used magnetic markers to track capsules moving through the digestive tract [6][7][8] using expensive cryogenically cooled superconducting quantum interference device or SQUID magnetic sensors. Other workers have used room temperature magnetic sensors to track a neodymium iron boron magnet inside the digestive tract [9] and ac magnetic susceptometry using about 1 g of tracer [10].…”

Section: Introductionmentioning

confidence: 99%