Magnetic lung measurements in relation to occupational exposure in asbestos miners and millers of Quebec

Cohen, David B.; Crowther, Thomas S.; Gibbs, Graham W.; Becklake, Margaret R.

doi:10.1016/0013-9351(81)90229-2

Cited by 37 publications

(4 citation statements)

References 11 publications

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“…There is a weak correlation between the remanent magnetic signal and work exposure, which suggests a balance between deposition and clearance in most of these workers. The average dust load in nonsmokers is greater than in smokers, probably due to airways constriction in the latter [27]. STROINK and eo-workers found equivalent figures: extreme values 0--640 mg, average value 71 mg [28].…”

Section: Determination Of the Total Quantity Of Aerocontaminants In T...mentioning

confidence: 94%

“…From 1976 onwards the lung dust loads of 47 shipyard welders has been measured every 3-6 months [7]. Yearly alveolar deposition is between 50 and 130 mg. Average retention after 10 yrs of continuous exposure is equal to 1 g and yearly clearance rate measured in retired welders is between 10 and 20%, which corresponds to an average clearance half-time of 3.5 yrs [27]. There are large inter-individual variations.…”

Section: Determination Of the Total Quantity Of Aerocontaminants In T...mentioning

confidence: 99%

See 1 more Smart Citation

Magnetopneumography: a general review

Gros

Lemaigre²,

Suon³

et al. 1989

Eur Respir J

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Magnetopneumography is the study of the remanent magnetism of foreign intrathoracic ferromagnetic particles after magnetization by an external magnetic field. Given knowledge of the magnetic characteristics of the inhaled particles, this highly sensitive and non-invasive technique allows the measurement of lung dust loads. Many groups of workers have been examined in this way, e.g. welders, coalminers, asbestos, foundry and steel workers. Magnetopneumography also allows analysis of the distribution of aerocontaminants in the different anatomical structures and, when repeated, the study of clearance speeds and migration from site to site of such particles. Emphasis has been laid on the importance of study of the fading of the remanent magnetic signal as time elapses. This short-term phenomenon, called relaxation, seems highly significant for the study of the dynamic properties of the immediate environment of extra pulmonary particles and especially for the study of macrophage activity.

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Section: Determination Of the Total Quantity Of Aerocontaminants In T...mentioning

confidence: 94%

Section: Determination Of the Total Quantity Of Aerocontaminants In T...mentioning

confidence: 99%

Magnetopneumography: a general review

Gros

Lemaigre²,

Suon³

et al. 1989

Eur Respir J

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“…Cohen et al [13] observed a significant relation between asbestos retention in the lungs and the exposure index in asbestos miners and combustion workers. The compensated ex-miners were found to present with more intensive RMF than were miners and healthy nonexposed persons [14].…”

Section: Lung Magnetometry In Humansmentioning

confidence: 98%

Magnetometric evaluation of toxicities of chemicals to the lungs and cells

Aizawa

Kudo

2010

Environ Health Prev Med

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Because the lungs are exposed to airborne hazardous materials, alveolar macrophages (AMs) play a major role in defending against the exposure to various noxious chemical substances. In this study, we reviewed magnetometric investigations of the effects of various chemicals on the lungs and AMs. Magnetometry, using magnetite as an indicator, was used to evaluate the effects of certain chemicals on the lung and AMs. A rapid decrease of the remanent magnetic field after the cessation of external magnetization, a phenomenon called relaxation, was impaired when the lungs and macrophages were exposed to toxic substances. The delayed in vivo relaxation observed in the lungs exposed to magnetite and gallium arsenide was almost identical to the in vitro relaxation observed in the AMs exposed to the same materials. Delayed relaxation was observed in the AMs exposed to silica dust; various fibers, such as chrysotile and some manmade mineral fibers; and toxic arsenic and cadmium compounds. The extracellular release of lactate dehydrogenase activity was found in the AMs exposed to the chemicals. Relaxation is attributed to the cytoskeletondriven rotation of phagosomes containing magnetite. While the exact mechanism of delayed relaxation due to exposure to harmful chemicals remains to be clarified, cell magnetometry appears to be useful for the safety screening of chemical substances.

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“…5 This has been shown to result in much higher concentrations of magnetized particles in arc welders when compared with asbestos workers and coal miners. [13][14][15] Steel mill workers and foundry workers also have been shown to have very high concentrations of iron in their lungs when using magnetopneumography. 16 In fact, among foundry workers, the magnetic potential was found to be directly related to the degree of radiographic changes associated with siderosis.…”

Section: Identification and Quantification Of An Inhaled Agentmentioning

confidence: 99%