Magnetic Iron Oxide Nanoparticles for Biomedical Applications

Laurent, Sophie; Bridot, Jean-Luc; Elst, Luce Vander; Müller, Robert N.

doi:10.4155/fmc.09.164

Cited by 160 publications

(105 citation statements)

References 182 publications

(185 reference statements)

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“…SSPIO are phagocytized or endocytized by monocytes, macrophages, or oligodendroglial cells of the RES and are thus removed from the blood stream so that they have a comparably short blood half-life of a few minutes [48] (AMI-25: 8 min., SHU-555A: 10 min.) [49]. SSPIO accumulate primarily in the liver (80 -90 %), spleen (5 -8 %), and bone marrow (1 -2 %) [49].…”

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

“…[49]. SSPIO accumulate primarily in the liver (80 -90 %), spleen (5 -8 %), and bone marrow (1 -2 %) [49]. In comparison, USPIO and VSOP have a longer blood half-life which makes it possible to use these as blood pool contrast agents (e. g. blood half-life AMI-227: 200 min., SHU 555C: 6 -8 h, VSOP-C184: 30 -60 min.)…”

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

“…In comparison, USPIO and VSOP have a longer blood half-life which makes it possible to use these as blood pool contrast agents (e. g. blood half-life AMI-227: 200 min., SHU 555C: 6 -8 h, VSOP-C184: 30 -60 min.) [49]. Small particles of less than 5 nm can pass through the glomerulus and be eliminated renally [50].…”

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

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Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

123

101

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Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

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Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

123

101

View full text Add to dashboard Cite

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“…MNPs have been utilized as nanocarriers for drugs, contrast imaging agents in magnetic resonance imaging (MRI), in local hyperthermia, and magnetic targeting. 24,25 However, high aggregation of MNPs is a common problem. High surface-to-volume ratios and van der Waals forces trigger opsonization and therefore, present a major obstacle for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Yallapu¹,

Othman²,

Curtis³

et al. 2012

IJN

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Background:The next generation magnetic nanoparticles (MNPs) with theranostic applications have attracted significant attention and will greatly improve nanomedicine in cancer therapeutics. Such novel MNP formulations must have ultra-low particle size, high inherent magnetic properties, effective imaging, drug targeting, and drug delivery properties. To achieve these characteristic properties, a curcumin-loaded MNP (MNP-CUR) formulation was developed. Methods: MNPs were prepared by chemical precipitation method and loaded with curcumin (CUR) using diffusion method. The physicochemical properties of MNP-CUR were characterized using dynamic light scattering, transmission electron microscopy, and spectroscopy. The internalization of MNP-CUR was achieved after 6 hours incubation with MDA-MB-231 breast cancer cells. The anticancer potential was evaluated by a tetrazolium-based dye and colony formation assays. Further, to prove MNP-CUR results in superior therapeutic effects over CUR, the mitochondrial membrane potential integrity and reactive oxygen species generation were determined. Magnetic resonance imaging capability and magnetic targeting property were also evaluated. Results: MNP-CUR exhibited individual particle grain size of ∼9 nm and hydrodynamic average aggregative particle size of ∼123 nm. Internalized MNP-CUR showed a preferential uptake in MDA-MB-231 cells in a concentration-dependent manner and demonstrated accumulation throughout the cell, which indicates that particles are not attached on the cell surface but internalized through endocytosis. MNP-CUR displayed strong anticancer properties compared to free CUR. MNP-CUR also amplified loss of potential integrity and generation of reactive oxygen species upon treatment compared to free CUR. Furthermore, MNP-CUR exhibited superior magnetic resonance imaging characteristics and significantly increased the targeting capability of CUR. Conclusion: MNP-CUR exhibits potent anticancer activity along with imaging and magnetic targeting capabilities. This approach can be extended to preclinical and clinical use and may have importance in cancer treatment and cancer imaging in the future. Further, if these nanoparticles can functionalize with antibody/ligands, they will serve as novel platforms for multiple biomedical applications.

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“…There are numerous ways to synthesise iron-oxide MNPs, many of which result in particles with differing sizes and shapes, which is highly undesirable [33]. Room temperature co-precipitation of iron-oxide MNPs (by addition of base to raise the pH of a mixed valence iron solution under an inert atmosphere) is simple, but results in a heterogeneous population of MNPs, which must be size filtered and magnetically separated before use.…”

Section: Forming Magnetopolymersomesmentioning

confidence: 99%

Synthesis of ABA Tri-Block Co-Polymer Magnetopolymersomes via Electroporation for Potential Medical Application

et al. 2015

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Abstract:The ABA tri-block copolymer poly(2-methyloxazoline)-poly(dimethylsiloxane)-poly(2-methyloxazoline) (PMOXA-PDMS-PMOXA) is known for its capacity to mimic a bilayer membrane in that it is able to form vesicular polymersome structures. For this reason, it is the subject of extensive research and enables the development of more robust, adaptable and biocompatible alternatives to natural liposomes for biomedical applications. However, the poor solubility of this polymer renders published methods for forming vesicles unreproducible, hindering research and development of these polymersomes. Here we present an adapted, simpler method for the production of PMOXA-PDMS-PMOXA polymersomes of a narrow polydispersity (45˘5.8 nm), via slow addition of aqueous solution to a new solvent/polymer mixture. We then magnetically functionalise these polymersomes to form magnetopolymersomes via in situ precipitation of iron-oxide magnetic nanoparticles (MNPs) within the PMOXA-PDMS-PMOXA polymersome core and membrane. This is achieved using electroporation to open pores within the membrane and to activate the formation of MNPs. The thick PMOXA-PDMS-PMOXA membrane is well known to be relatively non-permeable when compared to more commonly used di-block polymer membranes due a distinct difference in both size and chemistry and therefore very difficult to penetrate using standard biological methods. This paper presents for the first time the application of electroporation to an ABA tri-block polymersome membrane (PMOXA-PDMS-PMOXA) for intravesicular in situ precipitation of uniform MNPs (2.6˘0.5 nm). The electroporation process facilitates the transport of MNP reactants across the membrane yielding in situ precipitation of MNPs. Further to differences in length and chemistry, a tri-block polymersome membrane structure differs from a natural lipid or di-block polymer membrane and as such the application and effects of electroporation on this type of polymersome is entirely novel. A mechanism is hypothesised to explain the final structure and composition of these biomedically applicable tri-block magnetopolymersomes.

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Magnetic Iron Oxide Nanoparticles for Biomedical Applications

Cited by 160 publications

References 182 publications

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Synthesis of ABA Tri-Block Co-Polymer Magnetopolymersomes via Electroporation for Potential Medical Application

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