Magnetic hyperthermia with hard-magnetic nanoparticles

Kashevsky, B. E.; Kashevsky, S. B.; Korenkov, Victor S.; Istomin, Yu. P.; Terpinskaya, T. I.; Улащик, В. С.

doi:10.1016/j.jmmm.2014.10.109

Cited by 27 publications

(12 citation statements)

References 29 publications

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“…For the very small IOMNPs, the heat release rate is limited. As pointed out recently by Kashevsky et al [ 66 ], hard larger MNPs, with pronounced stationary hysteresis much closer to the Stoner Wohlfarth model, are theoretically able to release 24 times larger heat as compared to the small superparamagnetic ones and should be considered as good candidates for human hyperthermia applications. The major drawbacks in such applications for the large MNPs is related to their possible agglomeration and aggregation in vivo together with lower SAR values due to suppression of the Brownian relaxation by their immobilization either to the cell membranes or in the cytoplasm.…”

Section: Resultssupporting

confidence: 52%

Polyethylene Glycol-Mediated Synthesis of Cubic Iron Oxide Nanoparticles with High Heating Power

Iacoviță¹,

Știufiuc²,

Radu³

et al. 2015

Nanoscale Res Lett

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Iron oxide magnetic nanoparticles (IOMNPs) have been successfully synthesized by means of solvothermal reduction method employing polyethylene glycol (PEG200) as a solvent. The as-synthesized IOMNPs are poly-dispersed, highly crystalline, and exhibit a cubic shape. The size of IOMNPs is strongly dependent on the reaction time and the ration between the amount of magnetic precursor and PEG200 used in the synthesis method. At low magnetic precursor/PEG200 ratio, the cubic IOMNPs coexist with polyhedral IOMNPs. The structure and morphology of the IOMNPs were thoroughly investigated by using a wide range of techniques: TEM, XRD, XPS, FTIR, and RAMAN. XPS analysis showed that the IOMNPs comprise a crystalline magnetite core bearing on the outer surface functional groups from PEG200 and acetate. The presence of physisorbed PEG200 on the IOMNP surface is faintly detected through FT-IR spectroscopy. The surface of IOMNPs undergoes oxidation into maghemite as proven by RAMAN spectroscopy and the occurrence of satellite peaks in the Fe2p XP spectra. The magnetic studies performed on powder show that the blocking temperature (TB) of IOMNPs is around 300 K displaying a coercive field in between 160 and 170 Oe. Below the TB, the field-cooled (FC) curves turn concave and describe a plateau indicating that strong magnetic dipole-dipole interactions are manifested in between IOMNPs. The specific absorption rate (SAR) values increase with decreasing nanoparticle concentrations for the IOMNPs dispersed in water. The SAR dependence on the applied magnetic field, studied up to magnetic field amplitude of 60 kA/m, presents a sigmoid shape with saturation values up to 1700 W/g. By dispersing the IOMNPs in PEG600 (liquid) and PEG1000 (solid), it was found that the SAR values decrease by 50 or 75 %, indicating that the Brownian friction within the solvent was the main contributor to the heating power of IOMNPs.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-015-1091-0) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 52%

Polyethylene Glycol-Mediated Synthesis of Cubic Iron Oxide Nanoparticles with High Heating Power

Iacoviță¹,

Știufiuc²,

Radu³

et al. 2015

Nanoscale Res Lett

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“…Most important tissue values are given in Tab. I [11][12][13][14]. Electromagnetic filed describe following relations [6]:…”

Section: Equations Descrining Fields Distributionmentioning

confidence: 99%

Analysis of electromagnetic heating in magnetic fluid deep hyperthermia

Kurgan¹,

Gas²

2018

EasyChair Preprints

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In this paper, we describe the numerical modeling of magnetically induced heating of tissues in magnetic fluid deep hyperthermia. When placed in sinusoidal varying electromagnetic field, the Brownian particle rotation and Neel relaxation mechanisms induce in ferrofluid heat generation. In order to destroy tumors cells while preventing healthy tissues, such parameters as susceptibility of nanoparticles, exciting current parameters and intensity of magnetic fields should be calculated precisely. In this publication, coupled field problem resulting from Maxwell's equation and Penne's bioheat equation is discussed. Both sets of equations are solved using the finite element analysis method. We use a simplify model of human thorax with blood perfusion mechanism and tumor placed in it. Heat generation source in tumor is obtained by ferromagnetic nanoparticles. Magnetic and temperature field distribution is discussed in context of optimal tumor treatment.

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“…Due to clinical limitations on the amplitude of the external magnetic field H ext [ 4 , 6 , 10 ], the anisotropy axes of the spherical nanoparticles are not perfectly aligned to the external magnetic field. Due to the internal dipolar magnetic field, a local magnetic field appears in nanoparticle according to Eq.…”

Section: Interacting Colloidal Magnetic Nanoparticlesmentioning

confidence: 99%

“…In order to select an assembly of magnetic nanoparticles suitable for use in hyperthermia, it is of interest to establish the conditions providing a sufficiently high SLP in an alternating external magnetic field of moderate amplitude H ext and frequency f [ 5 ]. The latest researches suggest that the so-called “hard-magnetic nanoparticles” are a more reliable basis for practical magnetic hyperthermia than small nanoparticles [ 6 ]. Usually, the magnetite nanoparticles used in hyperthermia have a diameter above 53 nm but below the diameter above which objects are no more considered to be “nano” (100 or 200 nm, according to the bibliographic sources).…”

Section: Introductionmentioning

confidence: 99%

An adapted Coffey model for studying susceptibility losses in interacting magnetic nanoparticles

Osaci¹,

Cacciola²

2015

Beilstein J. Nanotechnol.

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Summary Background: Nanoparticles can be used in biomedical applications, such as contrast agents for magnetic resonance imaging, in tumor therapy or against cardiovascular diseases. Single-domain nanoparticles dissipate heat through susceptibility losses in two modes: Néel relaxation and Brownian relaxation. Results: Since a consistent theory for the Néel relaxation time that is applicable to systems of interacting nanoparticles has not yet been developed, we adapted the Coffey theoretical model for the Néel relaxation time in external magnetic fields in order to consider local dipolar magnetic fields. Then, we obtained the effective relaxation time. The effective relaxation time is further used for obtaining values of specific loss power (SLP) through linear response theory (LRT). A comparative analysis between our model and the discrete orientation model, more often used in literature, and a comparison with experimental data from literature have been carried out, in order to choose the optimal magnetic parameters of a nanoparticle system. Conclusion: In this way, we can study effects of the nanoparticle concentration on SLP in an acceptable range of frequencies and amplitudes of external magnetic fields for biomedical applications, especially for tumor therapy by magnetic hyperthermia.

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Magnetic hyperthermia with hard-magnetic nanoparticles

Cited by 27 publications

References 29 publications

Polyethylene Glycol-Mediated Synthesis of Cubic Iron Oxide Nanoparticles with High Heating Power

Polyethylene Glycol-Mediated Synthesis of Cubic Iron Oxide Nanoparticles with High Heating Power

Analysis of electromagnetic heating in magnetic fluid deep hyperthermia

An adapted Coffey model for studying susceptibility losses in interacting magnetic nanoparticles

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