2008
DOI: 10.1109/tmag.2008.2003508
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Magnetic Hyperthermia With Fe$_{3}$O$_{4}$ Nanoparticles: The Influence of Particle Size on Energy Absorption

Abstract: We have studied the magnetic and power absorption properties of a series of magnetic nanoparticles (MNPs) of Fe 3 O 4 with average sizes ranging from 3 to 26 nm. Heating experiments as a function of particle size revealed a strong increase in the specific power absorption (SPA) values for particles with = 25-30 nm. On the other side saturation magnetization M S values of these MNPs remain essentially constant for particles with above 10 nm, suggesting that the absorption mechanism is not determined… Show more

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Cited by 92 publications
(55 citation statements)
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“…[19] Also the size distribution σ obtained through successive synthesis were found within the 2 < σ < 5 nm range (i.e., 0.08 < σ/<d> < 0.2), which…”
Section: Resultsmentioning
confidence: 76%
“…[19] Also the size distribution σ obtained through successive synthesis were found within the 2 < σ < 5 nm range (i.e., 0.08 < σ/<d> < 0.2), which…”
Section: Resultsmentioning
confidence: 76%
“…a factor of 10) when the particle concentration increases from 0.00028% to 0.0112%. The value of SAR for gold nanoparticle under such a low heat flux is larger than many magnetic nanoparticles under high magnetic fields, which typically in the order of one hundred Watt per gram of magnetic nanoparticle [17][18][19] .…”
Section: Results Analysismentioning
confidence: 98%
“…[708] Although the biocompatibility of iron oxide has made it to one of the most desirable MNP used in hyperthermia, [642c] larger sizes of such MNPs are more prone to aggregation and have more difficulties in penetrating and dispersing within tumors. [709] For smaller sizes of iron oxide nanoparticles, the total heating efficiency regarding with hysteresis loss is reduced as a result of decrease in the saturation magnetization, [710] while Brownian and Neel relaxations become the relevant mechanisms to generate heat. [642c] Specifically, the rapid rotation of the particles themselves within a medium account for Brownian relaxation which is hindered by the viscosity of the medium to peter out the movement of particles.…”
Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning
confidence: 99%