Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

Abstract

In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.

A Fast, Reliable Oil-In-Water Microemulsion Procedure for Silica Coating of Ferromagnetic Zn Ferrite Nanoparticles Capable of Inducing Cancer Cell Death In Vitro

“…In the field of novel cancer therapy, magnetic nanoparticles (MNPs) are widely investigated within magnetic hyperthermia (MH) treatment [1][2][3]. The technique exploits the Néel magnetic relaxation, Brownian rotation, and hysteresis losses of MNPs, when subjected to an alternating magnetic field (AFM), to generate sufficient heat for inducing cancer cell death [4][5][6].…”

Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney

“…It may be useful to externally stimulate the release of the encapsulated drug [ 52 ] or to attract magnetically sensitive containers to the vessel walls [ 28 ] in order to make retention more effective. This moment may also be the most successful for the implementation of local photodynamic therapy [ 53 , 54 ] or magnetic hyperthermia [ 55 ]. This is due to the fact that at this moment, most of the drug dosage is localized in the vessels of the target kidney with the optimal selection of the injection volume.…”

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coatedBacillus subtilis

“…Alternatively, other SPIONs could be investigated to further enhance magnetic hyperthermia response in B. subtilis. Various SPIONs have been modified to improve magnetic hyperthermia properties [84][85][86][87] and these variations should be investigated for efficient coating of B. subtilis and improved magnetic hyperthermia after exposure to AMF.…”

“…SPIONs can be coated with polymers, small molecules, lipids and composites to increase stability, water solubility and biocompatibility. 85 For example, Fe 3 O 4 -oleic acid-Na-oleate nanoparticles 87 increased stability in a transplanted carcinoma model and polycaprolactone-coated superparamagnetic iron oxide nanoparticles synthesized with a micellular conformation to increase cytocompatibility and thermosensitivity as a cancer therapy. 85 Additionally, increasing RF amplitude and amount of iron associating with the bacteria could improve heating along with imaging properties in vivo .…”