Magnetic Hyperthermia Ablation of Tumors Using Injectable Fe₃O₄/Calcium Phosphate Cement

Abstract

In this work, we have developed an injectable and biodegradable material using CPC containing Fe3O4 nanoparticles for minimally invasive and efficiently magnetic hyperthermia ablation of tumors. When exposed to an alternating magnetic field, the MCPC could quickly generate heat. The temperature of PBS and the excised bovine liver increased with the MCPC weight, iron content, and time. The ablated liver tissue volume for 0.36 g of 10% MCPC was 0.2 ± 0.03, 1.01 ± 0.07, and 1.96 ± 0.19 cm(3), respectively, at the time point of 60, 180, and 300 s. In our in vivo experiment, the MCPC could be directly injected into the center of the tumors under the guidance of ultrasound imaging. The formed MCPC was well-restricted within the tumor tissues without leakage, and the tumors were completely ablated by 0.36 g of 10% injectable MCPC after 180 s of induction heating.

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

“…Magnetic nanomaterials can be employed in multi-modal treatments for tumor ablation, imaging, and controlled release [244]. Iron oxide NPs and a hydrophobic photosensitizer m-THCP, commercially used and known as Foscan, were loaded into the lipid bilayer of liposomes to pair magnetically induced hyperthermia and photodynamic therapy for tumor ablation [245].…”

Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles

“…Multifunctional nanomaterial-mediated fluorescence imaging 1-3, photoacoustic imaging 4-6, magnetic resonance imaging (MRI) 7-9, positron emission computed tomography (PET) imaging 10-12 and X-ray computed tomography (CT) imaging 13, 14 for more precise diagnosis of tumors have attracted ever-increasing attention. In addition, emerging nanomedicine in cancer therapy such as photothermal 1, 15, 16, photoacoustic 4, 6, 17, photodynamic 18-20, magnetic thermal 9, 21, 22, ultrasonic hyperthermia 23, 24, radiation therapy 25, 26 and microwave thermal therapy 27 have evoked great interest in their potential clinical application for cancer diagnostics and therapeutics research. Overall, multifunctional nanoparticle-mediated imaging and therapeutic techniques are likely to confer excellent leverage in improving precise diagnosis and targeted anticancer therapy.…”

Determining iron oxide nanoparticle heating efficiency and elucidating local nanoparticle temperature for application in agarose gel-based tumor model

“…These systems can then provide dual therapy in forms of MFH and chemotherapy which increases the therapeutic effectiveness compared to either of the treatments administered individually [8]. Recently, many of the MFH systems have been successfully utilized in vivo to cause a reduction in tumor mass, and demonstrate the potential of MFH to treat cancer using animal models [9 – 11]. MFH has also been used to target and reduce cancer stem cell populations in the body to minimize proliferation and metastasis of tumor cells [12, 13].…”