Magnetic hydroxyapatite coatings as a new tool in medicine: A scanning probe investigation

Gambardella, Alessandro; Bianchi, Michele; Kačiulis, S.; Mezzi, A.; Brucale, Marco; Cavallini, M.; Herrmannsdoerfer, T.; Chanda, G.; Uhlarz, M.; Cellini, Agnese; Pedna, Maria Federica; Sambri, Vittorio; Marcacci, Maurilio; Russo, Alessandro

doi:10.1016/j.msec.2016.01.071

Cited by 28 publications

(16 citation statements)

References 25 publications

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“…Methods used for coating metal implants with HAp include plasma spray [297][298][299][300][301], electrophoretic deposition [302][303][304][305], pulsed laser deposition [306][307][308][309], sol-gel deposition [310][311][312][313][314], spin-coating [290], sputtering techniques [315][316][317], ion assisted deposition [296,318,319], and many other techniques such as immersion, hot pressing and hot isostatic pressing, thermal spraying and electrostatic spraying [320,321]. Plasma spraying technique is one of the most economical methods.…”

Section: Coating Of Implantsmentioning

confidence: 99%

“…The coatings exhibited mechanical and compositional properties that met regulatory requirements, did not exhibit cytotoxicity to primary human bone cells, and exhibited antibacterial activity for E. coli and S. aureus. As well, magnetite-doped HAp films also have good biocompatibility [336] and destabilizing bacterial adhesion [300].…”

Section: Coating Of Implantsmentioning

confidence: 99%

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A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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Section: Coating Of Implantsmentioning

confidence: 99%

Section: Coating Of Implantsmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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“…The antibacterial tests, performed by evaluating the adhesion of Escherichia coli after 4 h of incubation on HA/magnetite and HA coatings with and without the presence of an external magnetic field (intensity 1.45 T), demonstrated the suitability of the HA/magnetite coatings in hindering the bacterial adhesion in comparison to HA coatings, independently from the application of the magnetic field [101]. According to the previous results [100], the presence of the magnetic field, induced by a permanent magnet placed below the samples, enhanced the anti-adhesive properties of the HA/magnetite coatings [101]. [93].…”

Section: Antibacterial Thin Films By Pedmentioning

confidence: 99%

The Pulsed Electron Deposition Technique for Biomedical Applications: A Review

et al. 2019

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The "pulsed electron deposition" (PED) technique, in which a solid target material is ablated by a fast, high-energy electron beam, was initially developed two decades ago for the deposition of thin films of metal oxides for photovoltaics, spintronics, memories, and superconductivity, and dielectric polymer layers. Recently, PED has been proposed for use in the biomedical field for the fabrication of hard and soft coatings. The first biomedical application was the deposition of low wear zirconium oxide coatings on the bearing components in total joint replacement. Since then, several works have reported the manufacturing and characterization of coatings of hydroxyapatite, calcium phosphate substituted (CaP), biogenic CaP, bioglass, and antibacterial coatings on both hard (metallic or ceramic) and soft (plastic or elastomeric) substrates. Due to the growing interest in PED, the current maturity of the technology and the low cost compared to other commonly used physical vapor deposition techniques, the purpose of this work was to review the principles of operation, the main applications, and the future perspectives of PED technology in medicine.

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“…Similar effects have been recognized by Gambardella et al investigating the morphology and the conductive properties of Hydroxyapatite films enriched with magnetite. In this case, roughness affects bacterial adhesion mechanisms triggered by porous/rough surfaces properties, ultimately inhibiting cells adhesion [68]. …”

Section: Major Applications In Scaffolds Designmentioning

confidence: 99%

Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering

Marrese

Guarino

Ambrosio

2017

JFB

107

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Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response. In particular, AFM is not only a mere tool for screening surface topography, but may offer a significant contribution to understand surface and interface properties, thus concurring to the optimization of biomaterials performance, processes, physical and chemical properties at the micro and nanoscale. This is possible by capitalizing the recent discoveries in nanotechnologies applied to soft matter such as atomic force spectroscopy to measure surface forces through force curves. By tip-sample local interactions, several information can be collected such as elasticity, viscoelasticity, surface charge densities and wettability. This paper overviews recent developments in AFM technology and imaging techniques by remarking differences in operational modes, the implementation of advanced tools and their current application in biomaterials science, in terms of characterization of polymeric devices in different forms (i.e., fibres, films or particles).

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Magnetic hydroxyapatite coatings as a new tool in medicine: A scanning probe investigation

Cited by 28 publications

References 25 publications

A brief review on hydroxyapatite production and use in biomedicine

A brief review on hydroxyapatite production and use in biomedicine

The Pulsed Electron Deposition Technique for Biomedical Applications: A Review

Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering

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