Magnetic hybrid magnetite/metal organic framework nanoparticles: facile preparation, post-synthetic biofunctionalization and tracking in vivo with magnetic methods

Tregubov, Andrey A.; Sokolov, I. L.; Babenyshev, Andrey V.; Никитин, П. И.; Cherkasov, V. R.; Nikitin, Maxim P.

doi:10.1016/j.jmmm.2017.10.070

Cited by 41 publications

(27 citation statements)

References 44 publications

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“…Recently, chitosan hydrogels loaded with the chromogenic substrate of β-glucuronidase, the enzyme secreted by E.coli strains, were employed to detect the enzyme in bacterial supernatants [39]. Lateral migration of IgG-conjugated magnetic nanoparticles through porous membranes accompanied by their specific, localized binding to the membrane-coupled antigens could be easily visualized and allowed for antigen identification [40]. The above and many similar applications might be realized using thin macroporous cryogel films described in the present study.…”

Section: Resultsmentioning

confidence: 99%

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Ivanov

Ljunggren

2019

Heliyon

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Thin macroporous poly(vinyl alcohol) (PVA) hydrogels were produced by cross-linking of PVA in a semi-frozen state with glutaraldehyde (GA) on glass slides or in the wells of microtiter plates. The 100-130 μm-thick gels were mechanically transferable, squamous translucent films with a high porosity of 7.2 ± 0.3 mL/g dry PVA i.e. similar to larger cylindrical PVA monoliths of the same composition. Additional treatment of the gels with 1% GA increased the aldehyde group content from 0.7 to 2.4 μmol/mL as estimated using dinitrophenylhydrazine (DNPH) reagent. Translucency of the gels allowed registration of UV-visible spectra of the DNPH-stained films. The catalytic activity of trypsin covalently immobilized on thin gels in the microtiter plates was estimated with chromogenic substrate directly in the wells, and indicated that the amount of protein immobilized was at least 0.34 mg/mL gel. Human immunoglobulin G (IgG) immobilized on thin gels at 0.1–10 mg/mL starting concentrations could be detected in a concentration-dependent manner due to recognition by anti-human rabbit IgG conjugated with peroxidase and photometric registration of the enzymatic activity. The results indicate good permeability of the hydrogel pores for macromolecular biospecific reagents and suggest applications of thin reactive PVA hydrogels in photometric analytical techniques.

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Section: Resultsmentioning

confidence: 99%

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Ivanov

Ljunggren

2019

Heliyon

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“…The author demonstrated the nanocomposite both as a multimodal (MRI contrasting, magnetometric and optical labeling) and multifunctional (in vivo bioimaging, biotargeting by coupled receptors, lateral flow assay) agents. [68a]…”

Section: Different Applications Of Magnetic Framework Compositesmentioning

confidence: 86%

“…One of the most promising materials in biomedical applications is MFCs which have some essential characteristics such as (a) the surface area of these materials are high and porous which allow loading considerable amount of active molecules; (b) they have uniform size pore and diverse chemistry; (c) they are also naturally biodegradable; (d) they show a reasonable response to the stimuli which help them to deliver drugs to target organs, (e) the responsivity of these materials to external stimuli is proper which can be decisive in releasing drugs, (f) they can be used in diagnostics as contrast agents . As a result, MFCs have been in the center of attention because of their large number of applications in this field . One of these applications is extracting and separating biomolecules.…”

Section: Different Applications Of Magnetic Framework Compositesmentioning

confidence: 99%

Fe₃O₄@MOF Magnetic Nanocomposites: Synthesis and Applications

Aghayi‐Anaraki

Safarifard

2020

Eur J Inorg Chem

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In this review, we gather a great deal of information about magnetic nanocomposites, which are made from the combination of Fe 3 O 4 magnetic nanoparticles (MNPs) and metal-organic frameworks (MOFs). Due to the high saturation magnetization, biocompatibility, low toxicity, stability, and costeffectiveness, MNPs have attracted a lot of interest in recent years. Furthermore, MOFs, which are porous materials, formed by the connection between organic linkers and metal ions. The combination of MNPs and MOFs results in the formation of magnetic framework composites (MFCs). The information about the MFCs is classified according to their applications and we

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“…As stated above, complexes based on magnetic particles and nucleic acids have multimodal properties; therefore, in addition to the direct gene delivery using such complexes, it is possible to carry out the magnetically controlled accumulation and release of particles [ 29 , 30 , 31 ], particle tracking by magnetic resonance imaging (MRI) [ 32 , 33 , 34 , 35 , 36 ], the imaging of tumors [ 37 , 38 ], and magnetic particle quantification (MPQ) studies [ 32 , 39 , 40 , 41 ], as well as magnetofection [ 9 , 42 , 43 ]. The term “magnetofection” refers to the use of a magnetic field and magnetic particles to improve the efficiency of gene delivery [ 44 , 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of “magnetic” drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

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Magnetic hybrid magnetite/metal organic framework nanoparticles: facile preparation, post-synthetic biofunctionalization and tracking in vivo with magnetic methods

Cited by 41 publications

References 44 publications

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Fe₃O₄@MOF Magnetic Nanocomposites: Synthesis and Applications

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

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Magnetic hybrid magnetite/metal organic framework nanoparticles: facile preparation, post-synthetic biofunctionalization and tracking in vivo with magnetic methods

Cited by 41 publications

References 44 publications

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Thin poly(vinyl alcohol) cryogels: reactive groups, macropores and translucency in microtiter plate assays

Fe3O4@MOF Magnetic Nanocomposites: Synthesis and Applications

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

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Product

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Fe₃O₄@MOF Magnetic Nanocomposites: Synthesis and Applications