Magnetic hybrid colloids decorated with Ag nanoparticles bite away bacteria and chemisorb viruses

Park, Hye Hun; Park, SungJun; Ko, GwangPyo; Woo, Kyoungja

doi:10.1039/c3tb20311e

Cited by 44 publications

(59 citation statements)

References 35 publications

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“…All of the magnetic hybrid colloids decorated with AgNPs of various sizes (AgNPMHCs) were synthesized by the Molecular Recognition Research Center of the Korea Institute of Science and Technology (KIST), Seoul, South Korea. Materials were used as purchased and as reported in our previous study (21). Ag07-MHC, Ag15-MHC, and Ag30-MHC were synthesized using the same procedure as reported in our previous studies (21,22).…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, silver nanoparticles of 7, 15, and 30 nm were grown on the outermost surface of a MHC through a seeding, coalescing, and growing strategy (21,22). Five milliliters of AP-MHC was mixed with 25 ml of Au seed solution (22).…”

Section: Methodsmentioning

confidence: 99%

“…In addition, monodispersed AgNPs are typically subject to particle-particle aggregation because of their small size and large surface area, and these aggregates reduce the effectiveness of AgNPs against microbial pathogens (7). Finally, AgNPs have been shown to have various cytotoxic effects (5,(18)(19)(20), and the release of AgNPs into a water environment could result in human health and ecological problems.Recently, we developed a novel micrometer-sized magnetic hybrid colloid (MHC) decorated with AgNPs of various sizes (21,22). The MHC core can be used to recover the AgNP composites from the environment.…”

mentioning

confidence: 99%

“…Recently, we developed a novel micrometer-sized magnetic hybrid colloid (MHC) decorated with AgNPs of various sizes (21,22). The MHC core can be used to recover the AgNP composites from the environment.…”

mentioning

confidence: 99%

“…Ag07-MHC, Ag15-MHC, and Ag30-MHC were synthesized using the same procedure as reported in our previous studies (21,22). An aminopropyl-functionalized Fe 3 O 4 -SiO 2 core-shell magnetic hybrid colloid (AP-MHC) stock solution containing 3.7 ϫ 10 10 AP-MHCs/ml was prepared and used as required.Briefly, silver nanoparticles of 7, 15, and 30 nm were grown on the outermost surface of a MHC through a seeding, coalescing, and growing strategy (21,22). Five milliliters of AP-MHC was mixed with 25 ml of Au seed solution (22).…”

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confidence: 99%

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Antiviral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid

Park

Kim

et al. 2014

Appl Environ Microbiol

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c Silver nanoparticles (AgNPs) are considered to be a potentially useful tool for controlling various pathogens. However, there are concerns about the release of AgNPs into environmental media, as they may generate adverse human health and ecological effects. In this study, we developed and evaluated a novel micrometer-sized magnetic hybrid colloid (MHC) decorated with variously sized AgNPs (AgNP-MHCs). After being applied for disinfection, these particles can be easily recovered from environmental media using their magnetic properties and remain effective for inactivating viral pathogens. We evaluated the efficacy of AgNP-MHCs for inactivating bacteriophage X174, murine norovirus (MNV), and adenovirus serotype 2 (AdV2). These target viruses were exposed to AgNP-MHCs for 1, 3, and 6 h at 25°C and then analyzed by plaque assay and real-time TaqMan PCR. The AgNP-MHCs were exposed to a wide range of pH levels and to tap and surface water to assess their antiviral effects under different environmental conditions. Among the three types of AgNP-MHCs tested, Ag30-MHCs displayed the highest efficacy for inactivating the viruses. The X174 and MNV were reduced by more than 2 log 10 after exposure to 4.6 ؋ 10 9 Ag30-MHCs/ml for 1 h. These results indicated that the AgNP-MHCs could be used to inactivate viral pathogens with minimum chance of potential release into environment. With recent advances in nanotechnology, nanoparticles have been receiving increased attention worldwide in the fields of biotechnology, medicine, and public health (1, 2). Owing to their high surface-to-volume ratio, nano-sized materials, typically ranging from 10 to 500 nm, have unique physicochemical properties compared with those of larger materials (1). The shape and size of nanomaterials can be controlled, and specific functional groups can be conjugated on their surfaces to enable interactions with certain proteins or intracellular uptake (3-5).Silver nanoparticles (AgNPs) have been widely studied as an antimicrobial agent (6). Silver is used in the creation of fine cutlery, for ornamentation, and in therapeutic agents. Silver compounds such as silver sulfadiazine and certain salts have been used as wound care products and as treatments for infectious diseases due to their antimicrobial properties (6, 7). Recent studies have revealed that AgNPs are very effective for inactivating various types of bacteria and viruses (8-11). AgNPs and Ag ϩ ions released from AgNPs interact directly with phosphorus-or sulfur-containing biomolecules, including DNA, RNA, and proteins (12-14). They have also been shown to generate reactive oxygen species (ROS), causing membrane damage in microorganisms (15). The size, shape, and concentration of AgNPs are also important factors that affect their antimicrobial capabilities (8,10,13,16,17).Previous studies have also highlighted several problems when AgNPs are used for controlling pathogens in a water environment. First, existing studies on the effectiveness of AgNPs for inactivating viral pathogens in water are limite...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antiviral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid

Park

Kim

et al. 2014

Appl Environ Microbiol

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129

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Luminescent Silver–Purine Double Helicate: Synthesis, Self‐Assembly and Antibacterial Action

et al. 2016

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How would you describe your research? We have designed al uminescent silver-purine helical coordination complex and studied its antibacterial activity against both Gram-positive and Gram-negative bacteria. The MIC values indicate that the complex exhibits significantly better activity against Gram-negative bacteria, especially against E. coli.L uminescent properties of this complex were used to study its bacterial cell uptake with the help of fluorescence and scanning electron microscopy methods. This study suggests that silver-purine double helical complexes could be used as potential antibacterial agents.

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Redox Properties on the Surfaces of Silica Networks Encapsulating Clusters of Superparamagnetic Magnetite Nanoparticles

Cho

et al. 2016

Eur J Inorg Chem

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Clusters of superparamagnetic magnetite nanoparticles encapsulated by thick silica shells (SiO2/cFe3O4) have been recognized as useful only in the role of a magnetically separable supporter. In this report, SiO2/cFe3O4 colloids based on a cFe3O4 core (367 nm) and a series of silica shell thicknesses (24, 47, 91, and 134 nm) were prepared and their charge transfer resistances (Rct) and the redox reactions of Ag+/AgNP on their surfaces were investigated. The Rct values of the SiO2/cFe3O4 series increased linearly as the silica shell thickness increased. The reductive elaboration of Ag+ to AgNPs by formaldehyde on the surfaces in the SiO2/cFe3O4 series was very poorly manageable in the case of the 24 nm shell but readily controllable as the silica thickness increased. The oxidative dissolution of AgNPs to Ag+ was more resistive as the silica shell thickness decreased. The surface plasmon band (ca. 405 nm) in the AgNP‐decorated SiO2/cFe3O4 series was progressively blue‐shifted (ca. 10 nm) as the silica thickness decreased, indicating a higher electron density on the AgNPs on the thinner silica shell. Overall results indicate that the cFe3O4 cores exhibit reductive properties through porous silica up to quite a long distance of over ca. 100 nm.

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Magnetic hybrid colloids decorated with Ag nanoparticles bite away bacteria and chemisorb viruses

Cited by 44 publications

References 35 publications

Antiviral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid

Antiviral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid

Luminescent Silver–Purine Double Helicate: Synthesis, Self‐Assembly and Antibacterial Action

Redox Properties on the Surfaces of Silica Networks Encapsulating Clusters of Superparamagnetic Magnetite Nanoparticles

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