Magnetic guidance of drug-carrying microspheres

Senyei, Andrew E.; Widder, Kenneth J.; Czerlinski, George

doi:10.1063/1.325219

Cited by 291 publications

(145 citation statements)

References 8 publications

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“…En concreto, proponemos el empleo de sistemas magnéticos de liberación. La idea de emplear partículas magnéticas como método de conducir el fármaco y favorecer su acumulación nació en los años 70 (Widder et al, 1979;Senyei et al, 1978). Sin embargo, sólo recientemente se ha profundizado en las aplicaciónes biomédicas de las nanopartículas magnéticas, en aspectos tales como imagen por resonancia magnética (Schlorf et al, 2011), hipertermia, o liberación de fármacos y genes (Gupta et al, 2007;Viota et al, 2011).…”

Section: Introducción Objetivosunclassified

“…Widder, Senyi and colleagues (Widder et al, 1979;Senyei et al, 1978) reported the first preclinical experiments exploiting magnetic albumin microspheres loaded with doxorubicin in rats. However, the idea of taking advantage of iron oxide nanoparticles in biomedical and clinical ap-plications is not only because of their magnetic features but also thanks to their enormous potential in great number of biomedical and in vivo clinical applications, like magnetic resonance imaging (MRI) (Schlorf et al, 2011), magnetic hyperthermia treatment, tissue repair, contrast enhancement and gene (McBain et al, 2008) and/or drug delivery (Gupta et al, 2007;Viota et al, 2011).…”

Section: Motivationmentioning

confidence: 99%

“…The awareness of this led researchers in the late 1970s to propose exploiting magnetic carriers in order to reach specific sites inside the body Senyei et al, 1978;Mosbach & Schröder, 1979). The goals are the following:…”

Section: Drug Deliverymentioning

confidence: 99%

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Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Introducción Objetivosunclassified

Section: Motivationmentioning

confidence: 99%

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Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…They showed the retention of the microspheres in the area of applied magnetic field by using an in vitro analog of the human circulatory system. [615] Since then, a lot of efforts were devoted in this area to improve MDT by designing various magnetic particles with minimized early clearance and more specific targeting to reduce the total dose required by increasing the concentration of drugs in blood vessels, especially in treating cancers. www.advancedsciencenews.com www.advhealthmat.…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Therefore, an anionic group of the first surfactant is conjugated to the cation of the iron oxide on the inside, with the functional groups of the second surfactant compatible with the liquid base pointing towards the outside [4]. Because the magnetic nanoparticles have superparamagnetism characteristic [5,6], their fluid flow can be reversibly controlled and localized at a specific site in dependence on the external magnetic field strength [7]. The high temperature viscosity of the ferrofluids is significantly important for vacuum seals, because the temperature of the motor reaches ~57°C under normal operating conditions.…”

Section: Introductionmentioning

confidence: 99%

Properties of Polyalphaolefin-Based Ferrofluids

Kim¹,

Park²

2015

Journal of Magnetics

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Magnetite nanoparticles were synthesized by adding excess ammonium hydroxide to a solution of iron (II) and (III) chlorides. The surfactants of oleic acid and Span 80 were applied in sequence to the magnetic particles as a combined stabilizer, and poly-α-olefin (PAO) 30 or 60 was used as the liquid base with a low or high viscosity, respectively. The ferrofluids were prepared with the concentrations of 200, 300, 400, and 500 mg/mL, and characterized by density, dispersion, magnetization, and viscosity. The density of the fluids increased proportionally to the concentration from 0.98 to 1.27 g/mL and 1.01 to 1.30 g/mL with PAO 30 base and PAO 60 base, and the dispersion stability was 77-95 and 81-74% for the PAO-30 and PAO-60-based fluids, respectively. The observed saturation magnetization values of the PAO-30 and PAO-60-based ferrofluids were 16 to 42 mT and 17 to 41 mT with the concentration increase in the range 200-500 mg/mL, respectively, depending upon the content of magnetic particles in the fluid. The viscosity variation of the PAO-30 and PAO-60-based ferrofluids in the temperature range 20-80°C was the least with the concentrations of 400 and 300 mg/ mL, respectively.

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Magnetic guidance of drug-carrying microspheres

Cited by 291 publications

References 8 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Properties of Polyalphaolefin-Based Ferrofluids

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