Magnetic Functionalized Nanoparticles for Biomedical, Drug Delivery and Imaging Applications

Abstract

Medicine is constantly looking for new and improved treatments for diseases, which need to have a high efficacy and be cost-effective, creating a large demand on scientific research to discover such new treatments. One important aspect of any treatment is the ability to be able to target only the illness and not cause harm to another healthy part of the body. For this reason, metallic nanoparticles have been and are currently being extensively researched for their possible medical uses, including medical imaging, antibacterial and antiviral applications. Superparamagnetic metal nanoparticles possess properties that allow them to be directed around the body with a magnetic field or directed to a magnetic implant, which opens up the potential to conjugate various bio-cargos to the nanoparticles that could then be directed for treatment in the body. Here we report on some of the current bio-medical applications of various metal nanoparticles, including single metal nanoparticles, functionalized metal nanoparticles, and core-shell metal nanoparticles using a core of Fe 3 O 4 as well as synthesis methods of these core-shell nanoparticles.

Differently Charged Super-Paramagnetic Iron Oxide Nanoparticles Preferentially Induced M1-Like Phenotype of Macrophages

“…Iron oxide nanoparticles have been widely used in biomedicine, imaging and drug delivery in preclinical, and clinical settings (Anderson et al, 2019), including photodynamic therapy, anemia, magnetic drug targeting, and modulating macrophage polarization (Ma et al, 2007;Bloemen et al, 2012;Macdougall and Geisser, 2013). Ferumoxytol is an iron oxide nanoparticle that has been approved by Food and Drug Administration (FDA) for nuclear magnetic resonance imaging and iron deficiency (Lu et al, 2010).…”

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

“…Nanorings has better heating performance, especially when they are under strong magnetic field so that consequently, they show a better tumor control in vivo . Despite the superior heating rates of some of the oddly shaped MIONS, it is important to be aware that the shape can also influence the rate of uptake and toxicity [126] . These factors must be considered when designing nanoparticles for clinical applications [97] …”

An Up-To-Date Review on Biomedical Applications of Palladium Nanoparticles

“…Metal nanostructures are gaining interest in a lot of biomedical applications owing to their shape and size; electronic, mechanic and optical properties; and their outstand resistance to corrosion and oxidation [1][2][3]. Metal nanostructures offer invaluable possibilities for new cancer therapies, targeted drug delivery, detection/diagnosis, and bioimaging [1,4,5]. Currently, gold, silver, iron, and platinum nanostructures are broadly studied in the biomedical field; several studies have taken the steps into clinical practice [6][7][8].…”