Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment

Yang, Feng; Jin, Chen; Yang, Dong; Jiang, Yongjian; Li, Ji; Yang, Di; Hu, Jianhua; Wang, Changchun; Ni, Quanxing; Fu, Deliang

doi:10.1016/j.ejca.2011.03.018

Cited by 162 publications

(101 citation statements)

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“…This loading efficiency was higher than loading efficiency (32%) reported by Tripisciano et al [34] for multiwall carbon nanotube conjugated with irinotecan. However, the loading efficiency observed in this study was comparable with the result of Yang et al [6] who reported the loading efficiency 62% for multiwall carbon nanotube containing gemcitabine as an anticancer drug. The cell line studies are essential for characterization of anticancer drug delivery systems and could provide valuable information for predicting drug behavior in the in vivo cancer studies.…”

Section: Discussionsupporting

confidence: 80%

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Fabrication, Characterization, and Functionalization of Single-Walled Carbon Nanotube Conjugated with Tamoxifen and Its Anticancer Potential against Human Breast Cancer Cells

Oskoueian

Матори

Bayat

et al. 2018

Journal of Nanomaterials

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In this experiment, we aimed to fabricate SWCNT conjugated with tamoxifen and evaluated its anticancer potential against human breast cancer cells (MCF-7). The results showed that SWCNT was synthetized successfully using chemical vapor deposition (CVD) method. The results of Raman spectroscopy, SEM, and TEM analyses confirmed the synthesis of highly pure SWCNT. The functionalization of SWCNT was performed by oxidizing of SWCNT, attachment of polyethylene glycol (PEG) to oxidized SWCNT, and attachment of azelaic acid to the polyethylene glycol group. As a result, the SWCNT with free functional carboxylic acid and hydroxyl groups (SWCNT-PEG) was developed. The SWCNT-PEG was then conjugated with tamoxifen (SWCNT-PEG-TAM). The FT-IR together with NMR results confirmed the conjugation of tamoxifen to functionalized SWCNT (SWCNT-PEG-TAM). The cytotoxic concentrations (CC 50 ) of SWCNT-PEG, tamoxifen, and SWCNT-PEG-TAM were >100, 12.67 ± 2.69, and 5.49 ± 1.34 g/ml, respectively. Linking tamoxifen to functionalized SWCNT enhanced the cytotoxic action of tamoxifen against breast cancer cells up to 2.3 times. The results of the morphological examination and caspase-3 activity confirmed the higher cytotoxic action of SWCNT-PEG-TAM as compared to free tamoxifen. The results obtained in this study indicated that this delivery system enhanced the therapeutic effects and anticancer potential of tamoxifen against human breast cancer cells.

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Section: Discussionsupporting

confidence: 80%

“…For instance, a study conducted by Yang et al [6] indicated that functionalized CNTs loaded with gemcitabine improved the cytotoxicity of gemcitabine against human pancreatic cancer cells (SW1990 and BxPC-3 cells). Similarly, the paclitaxel is also an anticancer drug with poor water solubility, low blood circulation time.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Characterization, and Functionalization of Single-Walled Carbon Nanotube Conjugated with Tamoxifen and Its Anticancer Potential against Human Breast Cancer Cells

Oskoueian

Матори

Bayat

et al. 2018

Journal of Nanomaterials

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“…Yang et al introduced a new magnetic lymphatic-targeting drug delivery system, based on functionalized carbon nanotubes. They achieved successful inhibition of lymph node metastasis by the subcutaneous administration of gemcitabine-loaded magnetic multiwalled carbon nanotubes as well as with loaded magnetic-activated carbon particles under a magnetic field [91] .…”

Section: Metastasized Cancerlimitations and Possibilitiesmentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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Abstract:Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of " theranostics " . The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

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“…It is efficient for the lymphatic system; metastases of certain cancers can be effectively inhibited [8] for subcutaneous injection. Adsorption on the PAA-CNT surface [9] is possible through coprecipitation of Fe3O4-based magnetic nanoparticles, polyacrylic acid (PAA) can be added to CNTs to become highly hydraulic.…”

Section: Target Drug Delivery For Cancer Therapymentioning

confidence: 99%

Recent Advances of Mechanical Engineering Applications in Medicine & Biology

Belhadj

Boudjemaa

2017

mèd technologies J.

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Background: Mechanics is an area of science dealing with the behavior of physical bodies (solids and fluids) undergoing action of forces, it comprised of statics, kinetics, and kinematics. The advances and research in Applied Mechanics has wide application in almost fields of study including medicine and biology. In this paper, the relationship between mechanical engineering and medicine and biological sciences is investigated based on its application in these two sacred fields. Some emergent mechanical techniques applied in medical sciences and practices are presented. Methods: Emerging applications of mechanical engineering in medical and biological sciences are presented and investigated including: biomechanics, nanomechanics and computational fluid dynamics (CFD). Results: This review article presents some recent advances of mechanical engineering applications in medicine and biology. Specifically, this work focuses on three major subjects of interests: Biomechanics that is increasingly being recognized as an important application of mechanical fundamentals in biomedical and biological sciences and practices, biomechanics can play a crucial role in both injury prevention as well as performance enhancement of living systems.  Novel techniques of nanomechanics including: Carbon nanotubes applications in therapy, DNA recognition, immunology, and antiviral resistance. Nanorobotics that combines between nanotechnology, mechanics and new biomaterials to design and develop nanorobots based bacteria and biochips; these nanoscale robots can be involved in biomedical applications, particularly for the treatment of cancer, cerebral aneurysm treatment, kidney stones removal surgery, treatment of pathology, elimination of defected parts in the DNA structure, and some other treatments to save human lives.  Computational fluid dynamics (CFD) tools that contribute on the understanding of blood flows, human organs dynamics and surgical options simulation. Conclusion: Recent advances of mechanical applications in medicine and biology are carried out in this review, such as biomechanics, nanomechanics and computational fluid dynamics (CFD). As perspectives, mechanical scholars and engineers can involve these cited applications in their researches to solve many problems and issues that doctors and biologists cannot.

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Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment

Cited by 162 publications

References 41 publications

Fabrication, Characterization, and Functionalization of Single-Walled Carbon Nanotube Conjugated with Tamoxifen and Its Anticancer Potential against Human Breast Cancer Cells

Fabrication, Characterization, and Functionalization of Single-Walled Carbon Nanotube Conjugated with Tamoxifen and Its Anticancer Potential against Human Breast Cancer Cells

Magnetic nanoparticles for cancer therapy

Recent Advances of Mechanical Engineering Applications in Medicine & Biology

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