Problems of stabilizing moduli of the type-IIB string theory on toroidal orientifolds T 6 /Z 2 , in presence of worldvolume fluxes on various D-branes, are considered. For Z 2 actions, introducing either O9 or O3 planes, we rule out the possibility of moduli stabilization in a wide class of models with N = 1 supersymmetry, characterized by the type of fluxes turned on along D-brane worldvolume. Our results, in particular, imply that Abelian worldvolume fluxes can not by themselves stabilize closed string moduli, in a consistent supersymmtric model, for above orientifold compactifications. We also discuss other Z 2 orientifolds of T 6 and show that certain other brane wrappings are also ruled out by similar consistency requirements. In specific setups we consider examples with D9-branes wrapping on a complex three-torus with its world-volume fluxes taken to be semi-homogeneous bundles and D7-branes wrapping holomorphic four-cycles of the complex three-torus carrying world-volume fluxes.