Magnetic fields at extremely low-frequency (50Hz, 0.8mT) can induce the uptake of intracellular calcium levels in osteoblasts

Zhang, Xu; Liu, Xiaoli; Pan, Leiting; Lee, Imshik

doi:10.1016/j.bbrc.2010.04.154

Cited by 64 publications

(43 citation statements)

References 25 publications

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“…Results obtained in the present investigation supports the earlier observations, which had reported the occurrence of oxidative/nitrosative stress in response to the MF exposure (Li and Chow 2000;Noda et al 2000;Kabuto et al 2001;Lee et al 2004), including effects on cell signaling processes (Liboff et al 2003;Zhang et al 2010) and carcinogenic effects (Bayazit et al 2010). Previous studies suggest that static and time-varying electric and MFs exposure caused oxidative DNA damage (Ivancsits et al 2003;Yokus et al 2005), increased plasma, liver, lung and kidney TBARS and SOD levels (Harakawa et al 2005;Guler (Jelenkovic et al 2005;Di Loreto et al 2009) altered cell proliferation , cortical serotonergic neurotransmission (Janac et al 2009) and memory impair (Jadidi et al 2007) in various biological organisms.…”

Section: Discussionsupporting

confidence: 92%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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Abstract. The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 µT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum > hippocampus > cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus > cerebellum > cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 µT than at 50 µT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions.

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Section: Discussionsupporting

confidence: 92%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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“…A 50 Hz ELF-PMF with lower values of both B value and exposure time, i.e., 0.8 mT and 8 min respectively, induces the uptake of intracellular calcium on murine osteoblasts [26]. Also a SMF is able to alter the intracellular calcium concentration (indicated as [Ca 2 )] i ).…”

Section: Incidence On Intracellular Calcium Concentrationmentioning

confidence: 99%

Comparative Analysis of Biological Effects Induced on Different Cell Types by Magnetic Fields with Magnetic Flux Densities in the Range of 1–60 mT and Frequencies up to 50 Hz

Vergallo

Dini

2018

Sustainability

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Abstract:Moderate static magnetic fields (SMFs) are generated from sources such as new-generation electric trams and trains, electric arc welding, and magnetic resonance imaging (MRI) devices, as well as during the industrial production of aluminium, while extremely low frequency pulsed magnetic fields (ELF-PMFs) are produced by house power installations, household appliances, and high voltages transmission lines. Moderate SMFs and ELF-PMFs with magnetic flux densities (B) in the range of 1-60 mT and frequencies (f ) up to 50 Hz are common MF exposure sources for the population. Even though humans are continually exposed to these MFs, to date no definitive endpoint has been drawn about their safety. In this review, the state of knowledge about the biological effects induced by these MFs on different cell types will be addressed. In our own observation, the putative modulation of Ca 2+ /H + and Na + /H + plasma membrane antiporters of human peripheral blood lymphocytes (PBLs) was found to occur after a 24 h exposure to a 6 mT SMF, and the bystander effect observed on U937 cells cultivated for up to 6 h in the conditioned medium harvested from human PBLs previously exposed for 24 h to the same MF (secondary necrosis induction) will be also herein discussed.

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“…Besides the effect on melatonin, EMF damage in genetic and other research level has been discussed also. It has been proposed that EMF theoretically is not able to produce sufficient energy to break DNA molecules or other chemical bonds, but may have a direct genotoxic effect in exposed persons, or disturb the concentration of intracellular calcium ion and the 6-hydroxy melatonin sulfate (Davis et al, 2001;Nordenson et al, 2001;Pessina et al, 2001;Zhang et al, 2010). But these hypotheses have not gained firm support from experimental researches because of conflicting results (Forssen et al, 2000;Christoffer, 2004;Chen et al, 2010).…”

Section: Discussionmentioning

confidence: 91%

Electromagnetic Field Exposure and Male Breast Cancer Risk: A Meta-analysis of 18 Studies

Sun¹,

Li²,

Gao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: The possibility that electromagnetic fields (EMF) exposure may increase male breast cancer risk has been discussed for a long time. However, arguments have been presented that studies limited by poor quality could have led to statistically significant results by chance or bias. Moreover, data fo the last 10 years have not been systematically summarized. Methods and Results: To confirm any possible association, a meta-analysis was performed by a systematic search strategy. Totals of 7 case-control and 11 cohort studies was identified and pooled ORs with 95% CIs were used as the principal outcome measures. Data from these studies were extracted with a standard meta-analysis procedure and grouped in relation to study design, cut-off point, exposure assessment method, adjustment and exposure model. A statistical significant increased risk of male breast cancer with EMF exposure was defined (pooled ORs = 1.32, 95% CI = 1.14 -1.52, P < 0.001), and subgroup analyses also showed similar results. Conclusions: This meta-analysis suggests that EMF exposure may be associated with the increase risk of male breast cancer despite the arguments raised.

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Magnetic fields at extremely low-frequency (50Hz, 0.8mT) can induce the uptake of intracellular calcium levels in osteoblasts

Cited by 64 publications

References 25 publications

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Comparative Analysis of Biological Effects Induced on Different Cell Types by Magnetic Fields with Magnetic Flux Densities in the Range of 1–60 mT and Frequencies up to 50 Hz

Electromagnetic Field Exposure and Male Breast Cancer Risk: A Meta-analysis of 18 Studies

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