Magnetic Fields and Acute Leukemia in Children With Down Syndrome

Mejı́a-Aranguré, Juan Manuel; Fajardo-Gutiérrez, Arturo; Pérez-Saldivar, María Luisa; Gorodezky, Clara; Martı́nez-Avalos, Armando; Romero-Guzmán, Lina; Campo-Martinez, Maria Angeles; Flores-Lujano, Janet; Salamanca-Gómez, F; Velásquez-Pérez, Leora

doi:10.1097/01.ede.0000248186.31452.be

Cited by 38 publications

(31 citation statements)

References 11 publications

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“…10,16,19,23,44 A small casecontrol study in Mexico examined at maternal age as a risk factor for acute leukemia in children with DS and reported no association. 45 Age was associated with acute leukemia risk as a continuous and categorical variable. Both variables indicated higher risk with increased age overall and in the AML subgroup.…”

Section: Discussionmentioning

confidence: 99%

Reproductive history, infertility treatment, and the risk of acute leukemia in children with down syndrome

Puumala

Ross

Olshan

et al. 2007

Cancer

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Background: Distal conduit obstruction is a recognized complication after surgery for congenital heart disease requiring implantation of a conduit from the right ventricle to the pulmonary arteries. Endovascular stenting of distal conduit obstruction can be challenging due to the proximity to the pulmonary artery bifurcation. Objective: A technique is described, whereby a single stent is mounted onto two balloon angioplasty catheters in tandem. This ensemble was delivered to the distal conduit/pulmonary artery via a large Mullins sheath on two guidewires, one placed in each of the branch pulmonary arteries. The aim was to assess safety and efficacy of this novel technique. Materials and Results: Seven patients (mean age 13.4 (6.7–23.4) years, mean weight 44.2 (23–69) kg were treated with this method. The pressure gradient was reduced from 36 (26–52) mm Hg to 11 (8–15) mm Hg [P< 0.05]. RV/LV pressure ratio decreased from 0.85 (0.6–0.95) to 0.42 (0.35–0.5) [P < 0.05]. There were no significant complications. During follow‐up over a median of 2.6 (0.3–6.7) years no patient required re‐intervention or surgery. Conclusion: This novel technique appears to be safe and effective for stenting stenoses just proximal to pulmonary artery bifurcation. © 2011 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Reproductive history, infertility treatment, and the risk of acute leukemia in children with down syndrome

Puumala

Ross

Olshan

et al. 2007

Cancer

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“…In fact, several papers suggest that asthma is a risk factor for AL in children with DS, whereas skin allergies seemed to protect the population from AL. Children with DS are more vulnerable to the effects of environmental factors that have been associated with the development of AL [25,26].…”

Section: Allergy and Hematologic Malignanciesmentioning

confidence: 99%

Allergy and risk of hematologic malignancies: Associations and mechanisms

Musolino¹,

Allegra²,

Minciullo³

et al. 2014

Leukemia Research

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Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms. Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.

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“…Children that are born with a high susceptibility to ALL, such as children with SD, should be the first among those that should be protected from exposure to environmental factors that potentially provoke ALL, such as tobacco smoke [29], exposure to magnetic fields of exClinical Epidemiology of Acute Lymphoblastic Leukemia -From the Molecules to the Clinictremely low frequency [69], etc. The approach of the precautionary principle should be followed, in that although the causal evidence is not absolute, the risk or the effect of the illness is so serious that putting oneself in contact the risk factor should be avoided [66,70].…”

Section: Discussionmentioning

confidence: 99%