Magnetic field responsive methylcellulose-polycaprolactone nanocomposite gels for targeted and controlled release of 5-fluorouracil

Nikjoo, Dariush; Aroguz, Ayse Z.

doi:10.1080/00914037.2015.1129954

Cited by 7 publications

(3 citation statements)

References 72 publications

(68 reference statements)

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“…This result shows that the interaction between the polymers caused the displacement of peak due to the interaction between C─H and O=C. This effect corroborates with other blends using PCL in the mixture [23].…”

Section: Resultssupporting

confidence: 88%

Investigation of the Ultraviolet Irradiation on Blend Films of PS/PCL

Segundo

Moraes

Levy

et al. 2021

EJERS

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In this work, an investigation was carried out on the effect of ultraviolet light on different films. Polystyrene (PS), poly (caprolactone) (PCL), and blended films of PS/PCL were produced. Ethyl acetate (AE) was used as a solvent, and PS and PCL solutions were prepared by dissolving 250 mg in 2.5mL of AE under mechanical stirring at room temperature. The blended solutions of PS/PCL (PS:PCL) were prepared with different mass proportions, such as 90:10, 80:20, 70:30, and 60:40 into 2.5 mL of EA. The solutions were dripped with 500 µL on a glass substrate, and the films were produced with mechanical rotation of N=2000 RPM for 15 seconds using a Spin coater. The films were submitted to ultraviolet light for t=60 minutes and morphologically analyzed by optical microscopy, chemically by IR spectroscopy, and superficially by contact angle and wettability; this last analysis also investigated the effect of ultraviolet light at t=0, t=30, and t=60 minutes. The exposure of ultraviolet light on the films affected its morphologies. IR spectra showed that the photodegradation increased for larger PCL amounts into the blend. The contact angle measurements showed that after exposure to ultraviolet light, the hydrophobicity of the films increased. Therefore, the presence of PCL in the polymer mixture promoted the photodegradation of the PS/PCL films, making it attractive for developing new packaging.

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Section: Resultssupporting

confidence: 88%

Investigation of the Ultraviolet Irradiation on Blend Films of PS/PCL

Segundo

Moraes

Levy

et al. 2021

EJERS

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“…[14,17,25] The above-mentioned properties along with its biodegradable nature, MC has been studied as a potential alternative to oil-based polymers, such as composite gels with poly(caprolactone), cement pastes, and composites with hydroxyapatite. [26][27][28] On the other hand, interest on nanocellulose composites has been growing rapidly in recent years. [29] Among nanocelluloses, cellulose nanocrystals (CNCs) are attractive reinforcing agents because of their large specific surface area, excellent mechanical properties (elastic modulus ~150 GPa), lightweight (density ~1.566 g/cm 3 ), sustainability, and renewability.…”

Section: Introductionmentioning

confidence: 99%

Methyl cellulose/cellulose nanocrystal nanocomposite fibers with high ductility

Hynninen

Mohammadi

Wagermaier

et al. 2019

European Polymer Journal

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Methylcellulose/cellulose nanocrystal (MC/CNC) nanocomposite fibers showing high ductility and high modulus of toughness were prepared by a simple aqueous wet-spinning from corresponding nanocomposite hydrogels into ethanol coagulation bath followed by drying. The hydrogel MC aq. concentration was maintained at 1 wt-% while the CNC aq. loading was systematically varied in the range 0 -3 wt-%. This approach resulted in MC/CNC fiber compositions from 25/75 wt-%/wt-% to 95/5 wt-%/wt-%. The optimal mechanical properties were achieved with the MC/CNC composition of 80/20 wt-%/wt-% allowing high strain (36.1 %) and modulus of toughness (48.3 MJ/m 3 ), still keeping a high strength (190 MPa). Further, we demonstrate that the continuous spinning of MC/CNC fibers is potentially possible. The results indicate possibilities to spin MC-based highly ductile composite fibers from environmentally benign aqueous solvents.

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“…76 developed a salecan-based magnetic hydrogel for drug release testing of doxorubicin hydrochloride (DOX). Salecan is a water-soluble extracellular glucan that has been copolymerized with vinylacetic acid (VA) and hydroxyethyl acrylate (HEA) in the presence of Fe 3 O 4 @ DOX pH/temperature/magnetic field-responsive release 91 DOX pH/temperature-responsive release magnetic chitosan nanocomposite 92 DOX pH-responsive release magnetic dextran microgels 80 DOX pH/magnetic fieldresponsive MNP@DAS@CPE 93 DOX pH-responsive release Fe 3 O 4 /P(NIPAM-AA-MAPEG) nanogels 94 DOX pH-responsive release glyoxal cross-linked porous magnetic chitosan microspheres 95 DOX pH-responsive release CS/PAA/Fe 3 O 4 nanocomposite 86 5-Fu pH-responsive release Fe 3 O 4 -Dex-MA-g P(NVI/NVCL) 96 5-Fu pH/temperature-responsive ferrogel (methacrylic acid or 2-aminoethyl methacrylate hydrochloride containing ferronanoparticles) 66 5-Fu pH/magnetic fieldresponsive release magnetic gelatin microspheres (MGMs) 20 5-Fu magnetic field-responsive MC-PCL magnetic hydrogel 97 5-Fu pH/magnetic fieldresponsive release CMCS-Fe 3 O 4 microspheres 98 5-Fu magnetic field-responsive release magnetic alginate/chitosan microspheres (DM-ACMSs) 62 DOX magnetic field-responsive release MPTMS-MNP-poly(GMA-g-MACD) 99 5-Fu pH-responsive release agarose nanoparticles and is suitable for hydrogel formation. At pH 4.5, cumulative DOX release reached 76% after 64 h, which was significantly higher than the 16.9 and 10.5% observed at pH 6.8 and 7.4, respectively.…”

Section: Drug Deliverymentioning

confidence: 99%

Advances in Biomedical and Environmental Applications of Magnetic Hydrogels

Singh

Datta

2023

ACS Appl. Polym. Mater.

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Hydrogels have been the focus of research across disciplines or subject perspectives owing to their distinctive chemical, physical, and mechanical characteristics. Hydrogels have been leveraged for their biocompatibility and attractive adhesion or adsorption behavior. Conventional hydrogels suffer from frequent entrapment due to low controllability, limited responsiveness, and weak actuation properties. Magnetic hydrogels address many of these concerns and offer a rapid magnetic response and precise temporal and spatial control. The structural and functional features of magnetic hydrogels can address overlapping requirements in biomedical and environmental applications. The focus of this review is on the progress made in the use of magnetic hydrogels. Specifically, their applications in controlled drug delivery as contrast agents in magnetic resonance imaging and in the treatment and remediation of wastewater are discussed. The first part of the review delineates strategies for preparing magnetic hydrogels and the advantages of each approach. The second part of the review describes a variety of biomedical and environmental applications for highlighting the convergent functionalities of magnetic hydrogels that are relevant to each domain. The challenges in the use of magnetic hydrogels and prospective applications are also included in the review.

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Magnetic field responsive methylcellulose-polycaprolactone nanocomposite gels for targeted and controlled release of 5-fluorouracil

Cited by 7 publications

References 72 publications

Investigation of the Ultraviolet Irradiation on Blend Films of PS/PCL

Investigation of the Ultraviolet Irradiation on Blend Films of PS/PCL

Methyl cellulose/cellulose nanocrystal nanocomposite fibers with high ductility

Advances in Biomedical and Environmental Applications of Magnetic Hydrogels

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