Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy

Thirunavukkarasu, Guru Karthikeyan; Cherukula, Kondareddy; Lee, Hwang-Jae; Jeong, Yong Yeon; Park, Inkyu; Lee, Jae Young

doi:10.1016/j.biomaterials.2018.07.028

Cited by 85 publications

(73 citation statements)

References 55 publications

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“…[ 52 , 53 ]. Two mechanisms are important for controlled drug release in the presence of an external magnetic stimulus: one is hyperthermia [ 54 ], and the other is drug targeting guided by a magnetic field [ 55 ]. Hypothermia-derived nanocarriers have gained significant attention in recent years.…”

Section: Types Of Stimulimentioning

confidence: 99%

“…Upon exposure to a magnetic field, SPIONs generated heat that led to the release of the drug. The success of this platform in both in vivo and in vitro studies revealed its promising chemotherapeutic attributes that should be explored in the future [ 54 ]. However, this system needs further investigation to overcome the problem of low drug loading and reduced specificity.…”

Section: Types Of Stimulimentioning

confidence: 99%

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Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Section: Types Of Stimulimentioning

confidence: 99%

Section: Types Of Stimulimentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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“…So far, iron oxide NPs have been employed for example in hyperthermia therapy on mice (18 mg Fe kg −1 body mass) or in photothermal therapy (coated with polypyrrole) acting as a target component to guide the NPs to the tumor site under an external magnetic field (3.3 mg Fe kg −1 body mass) [30,31]. The final concentration of Fe in the sample (30-50 μg mL −1 ) was determined by taking into account the abovementioned range of Fe doses and assuming the average body mass of a man as 70 kg and a blood volume of 5 L. The proper dilution of the protein-containing media also needs to be considered to prevent adsorption of the excess proteins onto the wall of the separation capillary, while also enabling observation of the sulfur signal originating from proteins.…”

Section: Preparation Of the Samplesmentioning

confidence: 99%

A CE-ICP-MS/MS method for the determination of superparamagnetic iron oxide nanoparticles under simulated physiological conditions

et al. 2020

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Over the past few years, superparamagnetic iron oxide nanoparticles (SPIONs) have attracted much attention due to their medicinally attractive properties and their possible application in cancer diagnosis and therapy. However, there is still a lack of appropriate methods to enable quantitative monitoring of the particle changes in a physiological environment, which could be beneficial for evaluating their in vitro and in vivo behavior. For this reason, the main goal of this study was the development of a novel capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS/MS) method for the determination of SPIONs suitable for the future examination of their changes upon incubation with proteins under simulated physiological conditions. The type and flow rate of the collision/reaction gas were chosen with the aim of simultaneous monitoring of Fe and S. The type and concentration of the background electrolyte, applied voltage, and sample loading were optimized to obtain SPION signals of the highest intensity and minimum half-width of the peak. Analytical parameters were at a satisfactory level: reproducibility (intra- and inter-day) of migration times and peak areas (presented as RSD) in the range of 0.23–4.98%, recovery: 96.7% and 93.3%, the limit of detection (for monitoring 56Fe16O+ by mass-shift approach) 54 ng mL−1 Fe (0.97 μM) and 101 ng mL−1 Fe (1.82 μM) for SPIONs with carboxyl and amino terminal groups, respectively. To the best of our knowledge, this is the first reported use of CE-ICP-MS/MS for the quantification of SPIONs and monitoring of interactions with proteins.

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“…Upon irradiation with an infrared laser or under the influence of an alternating magnetic field, many magnetic NPs undergo hyperthermia. It can be utilized in two major ways: enhanced drug release through the heat-expansion of a polymer coat (Zhang C. et al, 2017 ; Vijayan et al, 2019 ) and achieving temperatures above the minimum for inducing apoptosis (42°C) of surrounding cells (Thirunavukkarasu et al, 2018 ; Yar et al, 2018 ; Fetiveau et al, 2019 ) or by a combination of both methods (Vijayan et al, 2019 ). In all cases, once the nanomaterials had accumulated at the tumor site, they were triggered to reach required temperatures, resulting in a highly controlled and localized method for killing cancer cells.…”

Section: Therapeutic Propertiesmentioning

confidence: 99%

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

2020

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Theranostics is a fast-growing field due to demands for new, efficient therapeutics which could be precisely delivered to the target site using multimodal imaging with enhancing auxiliary actions. In this review article we discuss theranostic nanoplatforms containing polymers and magnetic nanoparticles along with other components. Magnetic nanoparticles allow for both diagnostic and therapeutic (hyperthermia) capabilities, while polymers can be reservoirs for drugs and are easily functionalized for cell targeting. We focus on the most important design strategies to achieve optimal theranostic effects as well as the roles of different components included in theranostics, reviewing the literature from the last 5 years.

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Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy

Cited by 85 publications

References 55 publications

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

A CE-ICP-MS/MS method for the determination of superparamagnetic iron oxide nanoparticles under simulated physiological conditions

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

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