Magnetic field-induced Ca2+ intake by mesenchymal stem cells is mediated by intracellular Zn2+ and accompanied by a Zn2+ influx

Özgün, Alp; Gari̇pcan, Bora

doi:10.1016/j.bbamcr.2021.119062

Cited by 7 publications

(6 citation statements)

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“…In recent years the cellular responses mobilized by PEMF exposure have come into clearer focus and commonly impinge upon calcium signaling and mitochondrial respiration (ROS) to reach fruition [ 14 , 20 , 48 – 53 ]. One calcium-permeable channel in particular, the Transient Receptor Potential Cation Channel Subfamily C Member 1, or TRPC1, has received attention [ 20 , 22 , 23 , 27 , 28 , 52 , 54 , 55 ]. A TRPC1-mitochondrial axis has been revealed that can be induced by magnetic stimulation and hence possesses the necessary functionality (calcium entry and mitochondrial interaction) to coalesce both aspects of the noted response cascade [ 22 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Muscle-targeted Pemf Therapy and Metabolic Stabilizationmentioning

confidence: 99%

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Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Venugobal

Tai

Goh

et al. 2023

Aging

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Brief (10 min) weekly exposure to low energy pulsed electromagnetic fields (PEMFs) has been shown to improve human muscle mitochondrial bioenergetics and attenuate systemic lipotoxicity following anterior cruciate ligament surgical reconstruction. Here we present data generated from 101 participants, 62% female, aged 38-91 years, recruited from the QuantumTx Demo Centre in Singapore, wherein 87% of participants (n = 88) presented with pre-existing mobility dysfunction and 13% (n = 13) were healthy volunteers. Participants were recruited if: (i) not pregnant; (ii) above 35 years of age and; (iii) without surgical implants. All participants completed mobility testing, pre-and post-PEMF intervention for 12 weeks, whereas bioelectrical impedance analysis was conducted in a subgroup of 42 and 33 participants at weeks 4 and 8, respectively.Weekly PEMF exposure was associated with significant improvements in mobility (Timed Up and Go, 5 times Sit-to-Stand, and 4m Normal Gait Speed) and body composition (increased skeletal muscle mass and reduced total and visceral fat mass), particularly in the older participants. Perception of pain was also significantly reduced. PEMF therapy may provide a manner to counteract age-associated mobility and metabolic disruptions and merits future investigation in randomized controlled trials to elucidate its clinical benefits in the frail and older adult populations.

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Section: Discussionmentioning

confidence: 99%

Section: Muscle-targeted Pemf Therapy and Metabolic Stabilizationmentioning

confidence: 99%

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Venugobal

Tai

Goh

et al. 2023

Aging

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“…The MdFI of SI persistent maters were normalized with the pseudorandomized paired SI non-maters (Supplementary Table 1) by the resolution metric. The resolution metric is commonly adopted in flow cytometry experiments (Romano et al ., 2021; Soh et al ., 2021; Özgün & Garipcan, 2021; Ditzig et al ., 2022), because it is able to account for various sources of noise in flow cytometry data (Bhowmick et al ., 2020). In our experiment, the resolution metric is defined as (MdFI SI persistent maters – MdFI SI non-maters )/(rSD SI persistent maters + □rSD SI non-maters ).…”

Section: Methodsmentioning

confidence: 99%

Neuron- and microglia-specific immunoexpression in steroid-independent male sexual behaviour in castrated B6D2F1 male mice

Chiang

Lipkin

McCusker

et al. 2022

Preprint

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Sexual behaviour is the sine qua non for procreation for several species and is traditionally viewed to be regulated by sex steroid hormones. However, several species exhibit steroid-independent sexual behaviour, and its molecular understanding is only beginning to be uncovered. We do not yet have a cell-specific understanding of the roles non-neuronal cells play in this phenomenon. Forty B6D2F1 hybrid male mice underwent orchidectomy and some of them exhibited consistent ejaculatory reflexes at least 62 weeks post-orchidectomy over 11 sexual behaviour tests (>180 minutes each), defined as steroid-independent (SI) maters (21.80%), and those that do not, defined as SI non-maters (25%). Using flow cytometry, we compared the preoptic area immunoexpression in NeuN+ neurons and Iba1+ microglia between SI maters and SI non-maters (n = 6 per group). We found neuronal immunoexpression up-regulated for amyloid precursor protein and androgen receptor, as well as down-regulated for glucocorticoid receptor. In conjunction, microglial immunoexpression of amyloid precursor protein up-regulated. These data suggest there are cell-specific immunoexpression changes including a role of non-neuronal cells in steroid-independent male sexual behaviour.

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“…The enzymatic and genetic cascades activated by extremely low-frequency pulsed electromagnetic field (ELF-PEMF) exposure have recently come into clearer focus [ 87 , 88 ] and are commonly shown to invoke mitochondrial survival adaptations [ 89 , 90 , 91 ] and calcium signalling pathways [ 92 , 93 , 94 , 95 , 96 , 97 ] in a variety of cell classes. These two cellular response limbs need not be mutually exclusive from each other [ 65 , 90 , 91 , 98 , 99 , 100 , 101 ] but likely converge at the level of the mitochondria via the reciprocal and synergistic capacities of calcium to modulate mitochondrial respiration [ 102 ] and of mitochondrially-derived ROS to modulate the multimodal and integrative function of TRPC1 [ 73 ]. The manner in which the implicated calcium pathway interacts with the mitochondria most likely involves classical pathways [ 100 ], whereas the nature of magnetoreception in all likelihood entails magnetically-tuneable changes in the lifetime of a radical pair formed between a cryptochrome moiety and the mitochondrial cofactor, flavin adenine dinucleotide [ 87 ]; both mechanisms mutualistically reinforcing the other.…”

Section: Trpc1 Confers Magnetic Mitohormesismentioning

confidence: 99%

The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective

Franco‐Obregón

Tai

et al. 2023

Bioengineering

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Muscle function reflects muscular mitochondrial status, which, in turn, is an adaptive response to physical activity, representing improvements in energy production for de novo biosynthesis or metabolic efficiency. Differences in muscle performance are manifestations of the expression of distinct contractile-protein isoforms and of mitochondrial-energy substrate utilization. Powerful contractures require immediate energy production from carbohydrates outside the mitochondria that exhaust rapidly. Sustained muscle contractions require aerobic energy production from fatty acids by the mitochondria that is slower and produces less force. These two patterns of muscle force generation are broadly classified as glycolytic or oxidative, respectively, and require disparate levels of increased contractile or mitochondrial protein production, respectively, to be effectively executed. Glycolytic muscle, hence, tends towards fibre hypertrophy, whereas oxidative fibres are more disposed towards increased mitochondrial content and efficiency, rather than hypertrophy. Although developmentally predetermined muscle classes exist, a degree of functional plasticity persists across all muscles post-birth that can be modulated by exercise and generally results in an increase in the oxidative character of muscle. Oxidative muscle is most strongly correlated with organismal metabolic balance and longevity because of the propensity of oxidative muscle for fatty-acid oxidation and associated anti-inflammatory ramifications which occur at the expense of glycolytic-muscle development and hypertrophy. This muscle-class size disparity is often at odds with common expectations that muscle mass should scale positively with improved health and longevity. Brief magnetic-field activation of the muscle mitochondrial pool has been shown to recapitulate key aspects of the oxidative-muscle phenotype with similar metabolic hallmarks. This review discusses the common genetic cascades invoked by endurance exercise and magnetic-field therapy and the potential physiological differences with regards to human health and longevity. Future human studies examining the physiological consequences of magnetic-field therapy are warranted.

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Magnetic field-induced Ca2+ intake by mesenchymal stem cells is mediated by intracellular Zn2+ and accompanied by a Zn2+ influx

Cited by 7 publications

References 50 publications

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Neuron- and microglia-specific immunoexpression in steroid-independent male sexual behaviour in castrated B6D2F1 male mice

The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective

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