Magnetic Field Effects in Biology: A Survey of Possible Mechanisms with Emphasis on Radical-Pair Recombination

Grissom, Charles B.

doi:10.1021/cr00033a001

Cited by 378 publications

(288 citation statements)

References 58 publications

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“…It is well established that the reactivity of a radical pair with certain properties (e.g., required separation distance and lifetime) will be affected by a magnetic field, whether it be externally applied or due to hyperfine coupling of magnetic nuclei like 25 Mg (I ¼ 5∕2) (2)(3)(4). What is more controversial in BK's mechanism is whether the radical pair forms in the first place, particularly because one of the radicals, Mg ·þ , is very unstable in an aqueous environment.…”

Section: Discussionmentioning

confidence: 99%

“…One possible reason for an influence of magnetic fields on biochemical reactions is the radical pair mechanism (2)(3)(4)(5)(6). In a series of papers by Buchachenko and Kuznetsov (BK) together with various co-workers (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), a radical pair mechanism has been proposed for enzymatic phosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP).…”

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confidence: 99%

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Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase

Crotty

Silkstone

Poddar

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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The influence of isotopically enriched magnesium on the creatine kinase catalyzed phosphorylation of adenosine diphosphate is examined in two independent series of experiments where adenosine triphosphate (ATP) concentrations were determined by a luciferase-linked luminescence end-point assay or a real-time spectrophotometric assay. No increase was observed between the rates of ATP production with natural Mg, 24 Mg, and 25 Mg, nor was any significant magnetic field effect observed in magnetic fields from 3 to 1,000 mT. Our results are in conflict with those reported by Buchachenko et al. [J Am Chem Soc 130:12868–12869 (2008)], and they challenge these authors’ general claims that a large (two- to threefold) magnetic isotope effect is “universally observable” for ATP-producing enzymes [Her Russ Acad Sci 80:22–28 (2010)] and that “enzymatic phosphorylation is an ion-radical, electron-spin-selective process” [Proc Natl Acad Sci USA 101:10793–10796 (2005)].

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase

Crotty

Silkstone

Poddar

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…Exciplex is regarded as a partially charge-separated state in nature, but it is unlikely that fluorescent exciplex formed directly from the contact pair of the LE state shows a significant magnetic field effect on spin conversion, because of the small D-A distance in exciplex, giving a large exchange interaction. Judging from the magnetic field effects in solution [21], intermolecular exciplex fluorescence originated from the contact pairs of the LE state and from RIP having a short D-A distance is supposed to be independent of H in PMMA, because of the rigidity and low polarity of the matrix [64]. In fact, the total intensity of the exciplex fluorescence of i.e., another exciplex fluorescence between ECZ and DMTP, which shows the magnetic field effects not only on I PL but also on I PL , was observed.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, magnetic field effects on intra-and intermolecular electron transfer processes have been examined to elucidate the PIET processes, and the observed magnetic field effect on fluorescence has been explained [20,21].…”

Section: Introductionmentioning

confidence: 99%

Magnetic field effects on electro-photoluminescence of photoinduced electron transfer systems in a polymer film

Awasthi

Ohta

2011

Journal of Photochemistry and Photobiology A: Chemistry

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Magnetic field effects on photoluminescence (PL) in the presence of external electric fields have been examined for a variety of electron donor and acceptor pairs, either linked with methylene chain or randomly distributed in polymethyl methacrylate (PMMA) films, which show intermolecular photoinduced electron transfer (PIET). Application of electric fields changes the energy separation among different electronic states, because the electric dipole moment at the state under consideration is usually different from the others. The energy levels within the same spin multiplicity are also shifted or splitted by application of magnetic field. Then, simultaneous application of electric field and magnetic field induces interesting effects on PL which cannot be observed when only electric field or magnetic field is applied to molecules. In this article, experimental results of the magnetic field effect of the electric field effect both on LE fluorescence and on exciplex fluorescence resulting from PIET are presented, and the mechanism of the synergy effects of the electric and magnetic fields on PL are discussed. The hyperfine interaction of the various radical-ion pairs produced by PIET has been also determined on the basis of the synergy effects on PL, and the results are compared with the calculated values.

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“…A variety of biological effects has been associated with exposure to low frequency electromagnetic fields (EMF), and have been proposed to be due, at least in part, to magnetic field (MF)-induced increases in free radical concentrations [1,2]. MF effects on the rate of radical pair (RP) recombination is a theoretically sound mechanism by which MF interact with biological systems [2], and is well-established in vitro in organicbased media [3,4].…”

Section: Introductionmentioning

confidence: 99%

The phorbol 12‐myristate 13‐ acetate (PMA)‐induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field

Roy¹,

Noda²,

Eckert³

et al. 1995

FEBS Letters

107

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Magnetic fields (MF) may affect biological systems by increasing free radical concentrations. To test this, we have investigated whether low frequency (60 Hz) low intensity (0.1 roT) MF can modulate the phorbol 12-myristate 13-acetate (PMA) induced respiratory burst in primed rat peritoneal neutrophils, followed in real time using the dye 2',7'-dichlorofluorescin (DCFH), which reacts with free radical-derived oxidants such as H202 (which is formed from the dismutation of superoxide) to become 2',7'-dichlorofluorecein (DCF), a highly fluorescent compound. In the presence of the MF, a 12.4% increase in the fluorescence signal was observed in PMA-stimulated neutrophils (n = 5, P < 0.02, 18 pairs of measurements). We believe this represents the first experimental observation of MF influencing events involving free radical species generated during signal transduction in living cells.

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Magnetic Field Effects in Biology: A Survey of Possible Mechanisms with Emphasis on Radical-Pair Recombination

Cited by 378 publications

References 58 publications

Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase

Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase

Magnetic field effects on electro-photoluminescence of photoinduced electron transfer systems in a polymer film

The phorbol 12‐myristate 13‐ acetate (PMA)‐induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field

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