Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi, Hadi; Simon, Christoph

doi:10.1098/rsif.2022.0325

Cited by 71 publications

(40 citation statements)

References 645 publications

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“…Furthermore, it has been shown that exposure to transcranial magnetic stimulation modulates the behaviour of the methamphetamine-administered patients [49–53]. Magnetic field effects are abundant in biology, and it has been suggested that the radical pair mechanism may underlie many of these phenomena [54]. To explore radical pair related quantum effects, here, one can test the effects of applied magnetic field and isotope effects, e.g., using 15 N in methamphetamine instead of the usual 14 N. It should be noted that 15 N and 14 N carry nuclear spin of 1/2 and 1, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Methamphetamine on Ultraweak Photon Emission and Level of Reactive Oxygen Species in Male Rat Brain

Lotfealian

Esmaeilpour

Anvari

et al. 2022

Preprint

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All living cells, including neurons, generate ultra-weak photon emission (UPE) during biological activity, and in particular, in the brain, it has been shown that UPE is correlated with neuronal activity and associated metabolic processes. Various intracellular factors, as well as external factors, can reduce or increase the intensity of UPE. In this study, we have used Methamphetamine (METH) as one potentially effective external factor, which is a substance that has the property of stimulating the central nervous system. METH can impair mitochondrial function by causing toxicity via various pathways, including an increase in the number of mitochondria, hyperthermia, the increased metabolic activity of the brain, and the production of glutamate and excess calcium. In addition to mitochondrial dysfunction, METH alters cellular homeostasis, leading to cell damage and the production of excess ROS. The aim of this study is to measure and compare the UPE intensity and reactive oxygen species (ROS) levels of the prefrontal, motor, and visual cortex before and after METH administration. Twenty male rats were randomly assigned to two groups, the control, and METH groups. In the control group, 2 hours after injection of normal saline and without any intervention, and in the experimental group 2 hours after IP injection of 20 mg/kg METH, sections were prepared from three areas: prefrontal, motor, and V1-V2 cortex, which were used to evaluate the emission of UPE using a photomultiplier tube (PMT) device and to evaluate the amount of ROS. The results showed that the amount of ROS and UPE in the experimental group in all three areas significantly increased compared to the control group. So, METH increases UPE and ROS in the prefrontal, motor, and visual regions, and there is a direct relationship between UPE intensity and ROS production. Therefore, UPE can be used as a dynamic reading tool to monitor oxidative metabolism in physiological processes related to ROS. Also, the results of this experiment can support the hypothesis that the production of excess UPE may lead to the phenomenon of phosphene and visual hallucinations.

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Section: Discussionmentioning

confidence: 99%

Effect of Methamphetamine on Ultraweak Photon Emission and Level of Reactive Oxygen Species in Male Rat Brain

Lotfealian

Esmaeilpour

Anvari

et al. 2022

Preprint

Self Cite

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“…Concepts of quantum biology (QB) began approximately 8 decades ago (McFadden and Al-Khalili, 2018) and aim to observe nontrivial, quantum signatures written into biochemical mechanisms that impact cellular function. One such mechanism is the RPM (Hogben et al, 2009) (Zadeh-Haghighi and Simon, 2022). Since the 1970s, the RPM has been used to describe the magnetic field effects on bird navigation (Hore and Mouritsen, 2016).…”

Section: Discussionmentioning

confidence: 99%

Quantum Biology in Cellular Migration

Vecheck

McNamee

Pera

et al. 2022

Preprint

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The impact of magnetic fields on cellular function is diverse but can be described at least in part by the Radical Pair Mechanism (RPM), where magnetic field intervention alters reactive oxygen species (ROS) populations and downstream cellular signaling. Here, cellular magnetophoresis within three-dimensional scaffolds was monitored in an applied oscillating 1.4 MHz radiofrequency (RF) magnetic field with an amplitude of 10 micro Tesla and a static 50 micro Tesla magnetic field. Given that cellular respiration or glycolysis can be increased based on the orientation of the RF magnetic field, this study focused on the parallel orientation to increase ATP synthesis. Results suggest that RF accelerated clustering and elongation after 1 day with increased levels of clustering and cellular linkage after 7 days. Electron microscopy provided additional topological information and verified the development of fibrous networks and extracellular matrix were visualized after 7 days in samples maintained in RF. Analysis of the distribution of cells within the scaffolds revealed that the clustering rate during the first day was increased nearly five times in the RF environment. This work demonstrates time-dependent cellular magnetophoresis that may be influenced by quantum biology (QB) processes and signaling that can further attenuate or enhance cellular bioenergetics and behavior.

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“…In this paper we will cite only a small fraction of the work that shows biological systems can detect and respond to exposures to EM fields at power levels that are well below the current safety guidelines for cellular communications devices. We have placed emphasis on those where we have direct personal knowledge of the results ( 3 ) references indicating effects from weak magnetic fields and there are thousands of papers where no significant effects have been observed.…”

Section: Literature Summarymentioning

confidence: 99%

Some thoughts on the possible health effects of electric and magnetic fields and exposure guidelines

Barnes

Freeman

2022

Front. Public Health

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Concerns about the possible health effects from exposure to weak electric and magnetic (EM) fields have been debated since the early 1960s. It is now well established that biological systems respond to exposure to weak EM fields at energy levels well below the current safety guidelines which result in modification of their functionality without significant changes in temperature. These observations are adding to the debate over what should be done to protect the users of cellular telecommunications systems. Experimental results showing both increases and decreases in cancer cell growth rates and concentration of reactive oxygen species for exposure to nano-Tesla magnetic fields at both radio frequencies (RF) and extra low frequencies (ELF) are cited in this paper. Some theoretical models on how variations in EM exposure can lead to different biological outcomes and how feedback and repair processes often mitigate potential health effects due to long-term exposure to low-level EM energy sources are presented. Of particular interest are the application of the radical pair mechanisms that affect polarization of electrons, and nuclear spins and the importance of time-delayed feedback loops and the timing of perturbations to oscillations in biological systems. These models help account for some of the apparently conflicting experimental results reported and suggest further investigation. These observations are discussed with particular emphasis on setting future safety guidelines for exposure to electromagnetic fields in cellular telecommunications systems. The papers cited are a very small fraction of those in the literature showing both biological effects and no effects from weak electric and magnetic fields.

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Magnetic field effects in biology from the perspective of the radical pair mechanism

Cited by 71 publications

References 645 publications

Effect of Methamphetamine on Ultraweak Photon Emission and Level of Reactive Oxygen Species in Male Rat Brain

Effect of Methamphetamine on Ultraweak Photon Emission and Level of Reactive Oxygen Species in Male Rat Brain

Quantum Biology in Cellular Migration

Some thoughts on the possible health effects of electric and magnetic fields and exposure guidelines

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