Magnetic Endoglin Aptamer Nanoprobe for Targeted Diagnosis of Solid Tumor

Zhong, Liping; Zou, Hang; Huang, Yong; Gong, Wenlin; He, Jian; Tan, Jie; Lai, Zongqiang; Li, Yanmei; Zhou, Chaofan; Zhang, Guoqing; Li, Guiyin; Yang, Nuo; Zhao, Yongxiang

doi:10.1166/jbn.2019.2688

Cited by 18 publications

(17 citation statements)

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“…Similarly, magnetic endoglin-specific aptamer nanoprobes based on modified magnetic carboxymethyl chitosan (CMCS) nanoparticles (aptamer-Fe 3 O 4 @CMCS) were generated to target subcutaneous H22 hepatocellular carcinomas in mice [ 87 ]. The results showed that tumor neovascularization could be accurately imaged with low toxicity and adequate biocompatibility by using aptamer-Fe 3 O 4 @CMCS for MRI.…”

Section: Resultsmentioning

confidence: 99%

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Sier

Vorst

Quax

et al. 2021

IJMS

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Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the progress in endoglin-based imaging of cancer, atherosclerosis, myocardial infarction, and aortic aneurysm, focusing on positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), near-infrared fluorescence (NIRF) imaging, and ultrasound imaging. PubMed was searched combining the following subjects and their respective synonyms or relevant subterms: “Endoglin”, “Imaging/Image-guided surgery”. In total, 59 papers were found eligible to be included: 58 reporting about preclinical animal or in vitro models and one ex vivo study in human organs. In addition to exact data extraction of imaging modality type, tumor or cardiovascular disease model, and tracer (class), outcomes were described via a narrative synthesis. Collectively, the data identify endoglin as a suitable target for intraoperative and diagnostic imaging of the neovasculature in tumors, whereas for cardiovascular diseases, the evidence remains scarce but promising.

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Section: Resultsmentioning

confidence: 99%

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Sier

Vorst

Quax

et al. 2021

IJMS

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“…The final nanoprobe consisted of the superparamagnetic Fe 3 O 4 producing T 2 contrast and carboxymethyl chitosan (CMCS) as the wrapping agent to ensure biocompatibility and reduced toxicity (as mEND-Fe 3 O 4 @CMCS). 26 As previously, the mEND aptamer was to serve as the recognition molecule, ensuring that the Fe 3 O 4 @CMCS contrast would be specifically delivered toward the target. The final 87 nm nanoprobe was tested to confirm targeting ability, as well as contrast enhancement.…”

Section: Targeted Contrast For Molecular Imagingmentioning

confidence: 99%

Advances in Medical Imaging: Aptamer- and Peptide-Targeted MRI and CT Contrast Agents

Koudrina

DeRosa

2020

ACS Omega

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Computed tomography (CT) and magnetic resonance imaging (MRI) are among the most well-established modalities in the field of noninvasive medical imaging. Despite being powerful tools, both suffer from a number of limitations and often fall short when it comes to full delineation of pathological tissues. Since its conception, molecular imaging has been commonly utilized to further the understanding of disease progression, as well as monitor treatment efficacy. This has naturally led to the advancement of the field of targeted imaging. Targeted imaging research is currently dominated by ligand-modified contrast media for applications in MRI and CT imaging. Although a plethora of targeting ligands exist, a fine balance between their size and target binding efficiency must be considered. This review will focus on aptamer- and peptide-modified contrast agents, outlining selected formulations developed in recent years while highlighting the advantages offered by these targeting ligands.

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“…This aptamer is conjugated to paramagnetic and fluorophore on the G5 dendrimer to form a targeted nanoprobe that can be used to detect tiny HCCs. Zhong et al[61] developed a nanoprobe targeting CD105 for MRI by the use of aptamer-modified magnetic carboxymethyl chitosan, which can improve the early diagnosis of HCC. In addition, Zhao et al[62] prepared a targeted MRI molecular probe based on ultrasmall superparamagnetic iron oxide (USPIO) mediated by phosphatidylinositol-3 (GPC3) aptamer.…”

Section: Application Of Aptamers In the Targeted Diagnosis Of Liver Cmentioning

confidence: 99%

Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

Zhang¹,

Zhong²,

Yang³

et al. 2019

WJG

Self Cite

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Aptamers are a class of single oligonucleotide molecules (DNA or RNA) that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology. The selected aptamers are capable of specifically binding to different targeting molecules, which is achieved by the three-dimensional structure of aptamers. Aptamers are similar in function to monoclonal antibodies, and therefore, they are also referred to as "chemical antibodies". Due to their high affinity and specificity and low immunogenicity, aptamers are topics of intense interest in today's biological targeting research especially in tumor research. They not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor therapy. Various experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for application. This paper summarizes the structure, characteristics, and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer.

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Magnetic Endoglin Aptamer Nanoprobe for Targeted Diagnosis of Solid Tumor

Cited by 18 publications

References 0 publications

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Advances in Medical Imaging: Aptamer- and Peptide-Targeted MRI and CT Contrast Agents

Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

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