Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging

Shanavas, Asifkhan; Sasidharan, Sisini; Bahadur, D.; Srivastava, Rohit

doi:10.1016/j.jcis.2016.09.060

Cited by 64 publications

(28 citation statements)

References 23 publications

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“…For example, Asifkhan et al combined the folate preconjugated chitosan and magnetic poly (lactide- co -glycolide) (PLGA) nanoparticles to create an MRI contrast agent (Fig. 2 ) [ 59 ]. The overall T2 relaxation time was shortened, and the nanoparticle relaxivity was enhanced thereby providing better imaging contrast [ 59 ].…”

Section: Nanotechnology-based Detection and Diagnostic Methodsmentioning

confidence: 99%

“…The overall T2 relaxation time was shortened, and the nanoparticle relaxivity was enhanced thereby providing better imaging contrast [ 59 ]. Meanwhile, the folate receptor positive KB oral cancer cells showed increased nanoparticle uptake and caused significant enhancement in cytotoxicity [ 59 ]. This nano agent not only provided high contrast cancer imaging but also simultaneously provided cancer therapy.…”

Section: Nanotechnology-based Detection and Diagnostic Methodsmentioning

confidence: 99%

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Nanotechnology: a promising method for oral cancer detection and diagnosis

et al. 2018

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Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

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Section: Nanotechnology-based Detection and Diagnostic Methodsmentioning

confidence: 99%

Section: Nanotechnology-based Detection and Diagnostic Methodsmentioning

confidence: 99%

Nanotechnology: a promising method for oral cancer detection and diagnosis

et al. 2018

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“…The in vitro study against folate-positive and -negative cancer cells showed improved uptake by a folate-positive cell line with no effect on magnetic properties and an overall shortened T 2 relaxation time. 104 emulsions Emulsion-based formulations are the most common way of efficiently administering lipophilic drugs. To overcome problems such as thermodynamic and kinetic instability, two new types of emulsions have been synthesized, that is, microemulsion and nanoemulsion.…”

Section: Theranostic Nanocarriersmentioning

confidence: 99%

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Sohail

Rehman

Sarwar

et al. 2018

IJN

102

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The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own. Recent advances in pharmaceutical research have focused on designing new and efficient drug delivery systems for site-specific targeting, thus leading to improved bioavailability and pharmacokinetics. A decent number of studies have been reported for the safe and effective oral delivery of Docetaxel. These nanocarriers, including liposomes, polymeric nanoparticles, metallic nanoparticles, hybrid nanoparticles, dendrimers and so on, have shown promising results in research papers and clinical trials. The present article comprehensively reviews the research efforts made so far in designing various advancements in the oral delivery of Docetaxel. Different strategies to improve oral bioavailability, prevent first-pass metabolism and inhibition of efflux pumping leading to improved pharmacokinetics and anticancer activity are discussed. The final portion of this review article presents key issues such as safety of nanomaterials, regulatory approval and future trends in nanomedicine research.

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“…[11][12][13][14][15] Various strategies have been employed to aggregate SPIONs into colloidal nano-and micro-sized objects. [11,[16][17][18][19][20][21] One of them consists in embedding SPIONs in a hydrolysable biocompatible polyester matrix, [22][23][24][25][26] but with some difficulty to reach the high content in magnetic material required by applications. [24,26,27] Another way is to densely pack SPIONs with oppositely charged polyelectrolytes into spherical or rod-like polyion complexes (PICs).…”

Section: Introductionmentioning

confidence: 99%

Auto-degradable and biocompatible superparamagnetic iron oxide nanoparticles/polypeptides colloidal polyion complexes with high density of magnetic material

Wang

Sandre

Wang

et al. 2019

Materials Science and Engineering: C

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Hypothesis: superparamagnetic iron oxide nanoparticles (SPIONs) are extensively used as building block of colloidal nanocomposites for biomedical applications. Strategies employed to embed them in a biodegradable and biocompatible polymer matrix often fail to achieve a high density of loading which would greatly benefit to applications such as imaging and hyperthermia. In this study, poly(acrylic acid) coated SPION (γ-Fe 2 O 3-PAA) are self-assembled with hydrolysable poly(serine ester) by electrostatic complexation, leading to perfectly defined spherical particles with ultra-high density of magnetic material and an ability to auto-degrade into individual SPION and biocompatible byproducts. Experiments: self-assembly and auto-degradation of γ-Fe 2 O 3-PAA/poly(serine ester) and γ-Fe 2 O 3-PAA/poly(serine ester)-b-PEG colloidal particles are studied by light scattering and microscopy. Colloidal stability in bio-fluids, hyperthermia under alternating magnetic field, cellular uptake, cytotoxicity and degradation of γ-Fe 2 O 3-PAA/poly(serine ester)-b-PEG in living cells are investigated. Findings: a remarkably slow electrostatic complexation leads to dense superparamagnetic γ-Fe 2 O 3-PAA/poly(serine ester)-b-PEG polyion complexes (PICs) with controlled sizes (150-500 nm) and times of degradation in aqueous solvents (700-5000 h). The material shows good sustainability during hyperthermia, is well taken up by MC3T3 cells and non-cytotoxic. TEM images reveal a mechanism of degradation by "peeling" and fragmentation. In cells, PICs are reduced into individual SPIONs within 72 h.

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Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging

Cited by 64 publications

References 23 publications

Nanotechnology: a promising method for oral cancer detection and diagnosis

Nanotechnology: a promising method for oral cancer detection and diagnosis

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Auto-degradable and biocompatible superparamagnetic iron oxide nanoparticles/polypeptides colloidal polyion complexes with high density of magnetic material

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