Magnetic-core-based silibinin nanopolymeric carriers for the treatment of renal cell cancer

Takke, Anjali; Shende, Pravin

doi:10.1016/j.lfs.2021.119377

Cited by 13 publications

(11 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLGA has also been used in the recent past to encapsulate MNPs [ 29 ], as well BMNPs [ 22 ]. In this second study, we demonstrated that PLGA and/or TAT–PLGA covering of BMNPs does improve the cell uptake of the nanoparticles, does not shelter the magnetic properties of the BMNPs, and maintains their ability to behave as hyperthermic agents.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Cytotoxic Effect of TAT–PLGA-Embedded DOXO Carried by Biomimetic Magnetic Nanoparticles upon Combination with Magnetic Hyperthermia and Photothermia

et al. 2021

View full text Add to dashboard Cite

The synergy between directed chemotherapy and thermal therapy (both magnetic hyperthermia and photothermia) mediated by a nanoassembly composed of functionalized biomimetic magnetic nanoparticles (BMNPs) with the chemotherapeutic drug doxorubicin (DOXO) covered by the polymer poly(lactic-co-glycolic acid) (PLGA), decorated with TAT peptide (here referred to as TAT–PLGA(DOXO-BMNPs)) is explored in the present study. The rationale behind this nanoassembly lies in an optimization of the nanoformulation DOXO-BMNPs, already demonstrated to be more efficient against tumor cells, both in vitro and in vivo, than systemic traditional therapies. By embedding DOXO-BMNPs into PLGA, which is further functionalized with the cell-penetrating TAT peptide, the resulting nanoassembly is able to mediate drug transport (using DOXO as a drug model) and behaves as a hyperthermic agent (induced by an alternating magnetic field (AMF) or by laser irradiation with a laser power density of 2 W/cm2). Our results obtained using the HepG2 cell line show that there is a synergy between chemotherapy and thermal therapy that results in a stronger cytotoxic effect when compared to that caused by the soluble DOXO. This is probably due to the enhanced DOXO release occurring upon the application of the thermal therapy, as well as the induced local temperature rise mediated by BMNPs in the nanoassembly following exposition to AMF or to near-infrared (NIR) laser irradiation. These results represent a proof of concept demonstrating that TAT–PLGA(DOXO-BMNPs) can be used to efficiently combine therapies against tumor cells, which is a step forward in the transition from systemic to local treatments.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhanced Cytotoxic Effect of TAT–PLGA-Embedded DOXO Carried by Biomimetic Magnetic Nanoparticles upon Combination with Magnetic Hyperthermia and Photothermia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Their apoptotic pathway triggered in RCC cells was determined to be induced by reactive oxygen species (ROS) imbalance and mitochondria-mediated pathways and to eventually result in cellular oxidative stress damage. Besides, Anjali Takke et al developed biocompatible magnetic-core-based nanopolymeric carriers of poly (D, l-lactide-co-glycolic) acid (PLGA) encapsulated silibinin (SLB) for the sustained release action [ 110 ]. SLB increased with the use of iron oxide nanoparticles through endocytic internalization into the cells.…”

Section: Treatment Of Renal Cell Carcinoma Using Nanomedicinementioning

confidence: 99%

Nanomedicine for renal cell carcinoma: imaging, treatment and beyond

Wang

Gai

et al. 2023

J Nanobiotechnol

View full text Add to dashboard Cite

The kidney is a vital organ responsible for maintaining homeostasis in the human body. However, renal cell carcinoma (RCC) is a common malignancy of the urinary system and represents a serious threat to human health. Although the overall survival of RCC has improved substantially with the development of cancer diagnosis and management, there are various reasons for treatment failure. Firstly, without any readily available biomarkers, timely diagnosis has been greatly hampered. Secondly, the imaging appearance also varies greatly, and its early detection often remains difficult. Thirdly, chemotherapy has been validated as unavailable for treating renal cancer in the clinic due to its intrinsic drug resistance. Concomitant with the progress of nanotechnological methods in pharmaceuticals, the management of kidney cancer has undergone a transformation in the recent decade. Nanotechnology has shown many advantages over widely used traditional methods, leading to broad biomedical applications ranging from drug delivery, prevention, diagnosis to treatment. This review focuses on nanotechnologies in RCC management and further discusses their biomedical translation with the aim of identifying the most promising nanomedicines for clinical needs. As our understanding of nanotechnologies continues to grow, more opportunities to improve the management of renal cancer are expected to emerge.

show abstract

“…In their study from 2021, Takke and Shende used iron oxide nanoparticles to create biocompatible nanopolymeric carriers of PLGA-encapsulated silibinin (SLB-MPNPs) for sustained release in kidney cancer cells [77]. The first synthetic stage involved the addition of H 2 O 2 to FeCl 2 solution to form a black precipitate, which was separated, washed, and dried to create iron oxide nanoparticles (MNPs).…”

Section: Iron Oxide-based Nanoparticlesmentioning

confidence: 99%

“…Iron oxide nanoparticles have been produced and formulated with flavonoids for applications in the treatment of ovarian cancer [75] after coating with mesoporous silica [11] or in the form of nanocomposite of Fe 2 O 3 , CHI, and montmorillonite (MMT) in breast cancer [74]. Methoxy poly(ethylene glycol) (mPEG)-b-PLGA-coated iron oxide nanoparticles seem to be suitable carriers of flavonoid compounds in the treatment of prostate cancer [76], whereas iron oxide NPs can serve as carriers of PLGA-encapsulated silibinin for sustained release in kidney cancer cells [77]. Iron oxide nanoparticles are also components of drug delivery systems applied in multimodal synergistic cancer therapy [79] and formulations used for the identification of selected proteins [81].…”

Section: To Sum Up Prosmentioning

confidence: 99%

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Sysak

Czarczyńska-Goślińska

Szyk

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhibit inflammation, angiogenesis, and metastasis. Polyphenols are also believed to reverse multidrug resistance via various mechanisms, induce apoptosis, and activate cell death signals in tumor cells by modulating cell signaling pathways. The main limitation to the broader usage of flavonoids is their low solubility, poor absorption, and rapid metabolism. To tackle this, the combining of flavonoids with nanocarriers could improve their bioavailability and create systems of wider functionalities. Recently, interest in hybrid materials based on combinations of metal nanoparticles with flavonoids has increased due to their unique physicochemical and biological properties, including improved selectivity toward target sites. In addition, flavonoids have further utilities, even in the initial step of preparation of metal nanomaterials. The review offers knowledge on multiple possibilities of the synthesis of flavonoid-metal nanoparticle conjugates, as well as presents some of their features such as size, shape, surface charge, and stability. The flavonoid-metal nanoparticles are also discussed regarding their biological properties and potential medical applications.

show abstract

Magnetic-core-based silibinin nanopolymeric carriers for the treatment of renal cell cancer

Cited by 13 publications

References 51 publications

Enhanced Cytotoxic Effect of TAT–PLGA-Embedded DOXO Carried by Biomimetic Magnetic Nanoparticles upon Combination with Magnetic Hyperthermia and Photothermia

Enhanced Cytotoxic Effect of TAT–PLGA-Embedded DOXO Carried by Biomimetic Magnetic Nanoparticles upon Combination with Magnetic Hyperthermia and Photothermia

Nanomedicine for renal cell carcinoma: imaging, treatment and beyond

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Contact Info

Product

Resources

About