Magnetic characterization of iron oxides for magnetic resonance imaging

Sjøgren, Carl E.; Briley‐Saebo, Karen C.; Hanson, M.; Johansson, Christer

doi:10.1002/mrm.1910310305

Cited by 59 publications

(25 citation statements)

References 10 publications

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“…The anionic salt content (chlorides, nitrates, sulphates etc. ), the Fe 2+ and Fe 3+ ratio, pH and the ionic strength in the aqueous solution all play a role in controlling the size (12). It is important to prevent the oxidation of the synthesized nanoparticles and protect their magnetic properties by carrying out the reaction in an oxygen free environment under inert gas such as nitrogen or argon (35).…”

Section: Synthesis Of Iron Oxide Nanoparticles and Superparamagnetic mentioning

confidence: 99%

Magnetic Nanoparticles for Cancer Diagnosis and Therapy

2012

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Nanotechnology is evolving as a new field that has a potentially high research and clinical impact. Medicine, in particular, could benefit from nanotechnology, due to emerging applications for noninvasive imaging and therapy. One important nanotechnological platform that has shown promise includes the so-called iron oxide nanoparticles. With specific relevance to cancer therapy, iron oxide nanoparticle-based therapy represents an important alternative to conventional chemotherapy, radiation, or surgery. Iron oxide nanoparticles are usually composed of three main components: an iron core, a polymer coating, and functional moieties. The biodegradable iron core can be designed to be superparamagnetic. This is particularly important, if the nanoparticles are to be used as a contrast agent for noninvasive magnetic resonance imaging (MRI). Surrounding the iron core is generally a polymer coating, which not only serves as a protective layer but also is a very important component for transforming nanoparticles into biomedical nanotools for in vivo applications. Finally, different moieties attached to the coating serve as targeting macromolecules, therapeutics payloads, or additional imaging tags. Despite the development of several nanoparticles for biomedical applications, we believe that iron oxide nanoparticles are still the most promising platform that can transform nanotechnology into a conventional medical discipline.

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Section: Synthesis Of Iron Oxide Nanoparticles and Superparamagnetic mentioning

confidence: 99%

Magnetic Nanoparticles for Cancer Diagnosis and Therapy

2012

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“…At alkaline pH, the black magnetite will precipitate, which can be chemically defined as shown in Eq. 14.1 [8,9].…”

Section: Synthesis Of Magnetic Nanoparticlesmentioning

confidence: 99%

Magnetic Nanoparticles in Tissue Regeneration

Tripathi¹,

Melo²,

D’Souza³

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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The remote control operation and manipulation of cells is the prime advantage of magnetic nanoparticles. Control of specific cellular components in vitro as well as in vivo offers a powerful tool for the understanding of cellular functions and molecular signaling to scientist, which helps to develop precise therapeutic applications by clinicians. Cells surface or intracellular labeling by the use of magnetic nanoparticles as an investigation tool in its preliminary stage are successfully developed for the diagnostic and other biomedical applications. Currently, magnetic nanoparticle applications have prominently shifted their focus towards the engineering of cells and their fate in the determination at a molecular level for three-dimensional tissue regeneration. Magnetic force-assisted tissue engineering is often referred to as a "Mag-TE." This chapter is divided into two main sections. The first section presents an overview about the properties, synthesis and structure of magnetic nanoparticles. The second section focuses on how magnetic nanoparticles have been applied in the cell directed tissue engineering and regenerative medicine with potential future prospects.

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“…The control of size, shape and composition of NPs depends on the type of salts used (e.g., chlorides, sulphates, nitrates or perchlorates), the Fe 2+ and Fe 3+ ratio, pH and ionic strength of the media [29,30]. Furthermore, the precipitation to obtain the particles can be performed in constrained domains.…”

Section: Preparation Of Ionpsmentioning

confidence: 99%

Peptides and Metallic Nanoparticles for Biomedical Applications

et al. 2007

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In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the peptides and metallic nanoparticles. An overview of the techniques used for the characterization of the conjugates is also provided. Mainly for biomedical purposes, metallic nanoparticles conjugated to peptides have been prepared from Au and iron oxide (magnetic nanoparticles). Peptides with the capacity to penetrate the plasma membrane are used to deliver nanoparticles to the cell. In addition, peptides that recognize specific cell receptors are used for targeting nanoparticles. The potential application of peptide-nanoparticle conjugates in cancer and Alzheimer's disease therapy is discussed. Several peptide-nanoparticle conjugates show biocompatibility and present a low degree of cytotoxicity. Furthermore, several peptide-metallic nanoparticle conjugates are used for in vitro diagnosis.

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Magnetic characterization of iron oxides for magnetic resonance imaging

Cited by 59 publications

References 10 publications

Magnetic Nanoparticles for Cancer Diagnosis and Therapy

Magnetic Nanoparticles for Cancer Diagnosis and Therapy

Magnetic Nanoparticles in Tissue Regeneration

Peptides and Metallic Nanoparticles for Biomedical Applications

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