Magnetic biopolymer nanogels via biological assembly for vectoring delivery of biopharmaceuticals

Fan, Ming; Yan, Jingxuan; Tan, Huaping; Miao, Yuting; Hu, Xiaohong

doi:10.1039/c4tb01106f

Cited by 35 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fan et al. have developed a magnetic biopolymer based nanogels chitosan and heparin by specific nucleobase pairing between thymine and adenine via the hydrogen bonding for vectoring delivery of bone morphogenetic protein 2 (BMP‐2) . The encapsulation of IONPs gave the magnetic biopolymer nanogels magnetic responsibility.…”

Section: Magnetic‐based Drug Delivery For Bone Growthmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

View full text Add to dashboard Cite

The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumor excision, still faces many challenges despite the intense investigations and advancement in bone-tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years. This Minireview aims to summarize the relevant progress and describes the following five aspects: (i) The general introduction of IONPs, with a focus on the magnetic properties as the base of application; (ii) using IONPs as tools to study and control stem cells for better treatment efficacy in stem-cell-based bone defect repair; (iii) the use of IONPs and their complexes in the delivery of therapeutic agents, including chemical drug molecules, growth factors, and genetic materials, to promote osteogenesis-related cell function and differentiation, healthy bone tissue growth, and functional reconstruction; (iv) magneto-mechanical actuation in the regulation of cells distribution, mechano-transduction membrane receptors activation, and mechanosensitive signaling pathways regulation, and (v) fabrication, characteristics, and in vitro and in vivo osteogenic effects of magnetic composite bone scaffolds. Ongoing prospects are also discussed.

show abstract

Section: Magnetic‐based Drug Delivery For Bone Growthmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

View full text Add to dashboard Cite

show abstract

“…Biopolymers owing to their biodegradable biocompatible and safe characteristics have gained widespread utilization in tissue engineering applications [135][136][137][138]. Fan et al (2014) reported preparation of a biopolymer based magnetic nanogels of 109.4 nm by coupling heparin and CHI with adenine and thymine nucleobases and subsequent encapsulation of Fe 3 O 4 magnetic nanoparticles in self-assembled nanogels [139]. In vitro release of bone morphogenetic protein 2 (BMP-2) as growth factor in physiological conditions and their cytotoxicity to MG-63 bone osteosar- Beside single targeting and stimulus directed control over the release behaviors of micro nanogels, development of particles with combined multiple targeting and stimuli responsivity gave rise to emergence of multifunctional captivating materials that provide more stable and controlled delivery to target sites of interest and achieve elongated systemic circulation half-lives.…”

Section: Stimuli Responsive Micro/nanogels and Targeted Drug Deliverymentioning

confidence: 99%

Micro and Nanogels for Biomedical Applications

Can

Güven

Şahiner

2020

Hacettepe Journal of Biology and Chemistry

View full text Add to dashboard Cite

D oğal ve sentetik polimerlerden geliştirilen mikro ve nano hidrojeller, yüksek yüzey alanı, yüksek derecede şişme, yüksek aktif madde yükleme kapasiteleri, yumuşaklık esneklik ve doğal dokulara benzerlikleri nedeniyle bilimsel ve endüstriyel alanda büyük ilgi görmüştür. Özellikle, biyouyumlu, toksik olmayan ve biyobozunur mikro/nano taşıyıcıların uygulamaya özgü tasarım ve fonksiyonelleştirilebilme olanakları, doku mühendisliği, biyo görüntüleme ve ilaç taşıma/teslim uygulamaları gibi çeşitli biyomedikal uygulamalar için mükemmel bir fizibilite sunmaktadır. Bununla birlikte, bu platformların in vivo ortamlardaki biyolojik bariyerleri aşabilmesi ve klinik uygulamalarda kullanıma girebilmesi için rasyonel tasarım ve işlevselleştirme stratejileri gerekmektedir. İlk olarak, ideal bir taşıyıcı biyo-uyumlu olmalı ve bağışıklık sisteminin eliminasyonundan kaçabilmeli, özellikle de istenen bölgeleri hedeflemeli ve ortam koşullarına duyarlı olarak terapötik yükü sürdürülebilir bir şekilde salabilmelidir. Mikro/nano materyal tasarımında küçük sorunlara rağmen klinik kullanıma giren birkaç başarılı formülasyon mevcuttur ve bu taşıyıcıların çoğu, tüm biyolojik kriterler için henüz tam bir başarı sağlayamamışlardır. Bu derlemede, mikro ve nanojellerin tasarım ve işlevselleştirme stratejileri özetlenerek mikro-ve nanojellerin biyomedikal uygulamalarındaki son gelişmeler, ilaç ve biyomolekül salım uygulamalarına ağırlık vererek özetlenmiştir.

show abstract

“…The biological self-assembly PEG hydrogel system is established by the Watson-Crick base pairing between thymine (T) and adenine (A) via the hydrogen bonding (Figure 2a). Compared with linear PEG, multi-arm star-shaped PEG has the nature to induce stereo-complex formation, which shows promise in biomedically relevant hydrogel systems (M. Fan, Yan, Tan, Miao et al, 2014;H. Tan, Xiao et al, 2012).…”

Section: Nucleobase Pairingmentioning

confidence: 99%

Biocompatible conjugation for biodegradable hydrogels as drug and cell scaffolds

Fan

Tan

2020

Cogent Engineering

Self Cite

View full text Add to dashboard Cite

Biodegradable and biocompatible hydrogels have many different applications in the field of biomedicine. The hydrogels could be utilized as drug carriers and cell scaffolds for drug delivery and tissue engineering. The hydrogels are appealing scaffolds because they are structurally similar to the extracellular matrix (ECM) of many tissues, which can often be delivered in a minimally invasive manner. A major issue in the use of a hydrogel scaffold is that the establishment of a biomimic environment is necessary for engineered tissue survival. In tissue engineering, there is significant interest in exploiting biocompatible conjugation to construct mimics of ECM for cells culture applications. Recently, a variety of crosslinking strategies have been developed for the fabrication of hydrogels, which are based on an affinity interaction, ionic interaction, electrostatic interaction, hydrophobic interaction, hydrogen bonding, crystallinity and covalent conjugation. This review will discuss recent advances in the field of biodegradable hydrogels crosslinked via biocompatible conjugation, including both physical and covalent crosslinking, which can be potentially used as drug and cell scaffolds in regenerative medicine applications.

show abstract

Magnetic biopolymer nanogels via biological assembly for vectoring delivery of biopharmaceuticals

Abstract: Biopolymer-based nanogels have great potential in the field of tissue regenerative medicine.

Cited by 35 publications

References 34 publications

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Micro and Nanogels for Biomedical Applications

Biocompatible conjugation for biodegradable hydrogels as drug and cell scaffolds

Contact Info

Product

Resources

About