Magnetic bio-hybrid micro actuators

Quashie, David; Benhal, Prateek; Chen, Zhi; Wang, Zihan; Mu, Xueliang; Song, Xiaoxia; Jiang, Teng; Zhong, Yukun; Cheang, U Kei; Ali, Jamel

doi:10.1039/d2nr00152g

Cited by 22 publications

(14 citation statements)

References 136 publications

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“…Moreover, if the MNR be recovered in time after performing tasks in the body, it can cause inflammation and other adverse reactions. The natural biological affinity of cells has inspired the design of MNRs, and on that basis, biological hybrid robots have been proposed (e.g., a swimmer combining MNR with bacteria [ 49 ] or cells). [ 50,51 ] Cellular MNRs mainly pack drugs and magnetic nanoparticles into cells (e.g., erythrocytes, [ 52 ] macrophages) by wrapping magnetic materials in cell membranes or through endocytosis.…”

Section: Fea Of Mnr Designmentioning

confidence: 99%

Advances in Finite Element Analysis of External Field‐Driven Micro/Nanorobots: A Review

Liu

Feng

et al. 2023

Advanced Intelligent Systems

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With the development of nanotechnology, micro/nanorobots (MNRs) have become promising medical tools given their advantages of unconstrained and precisely controlled navigation. However, given the complexity of MNRs’ dynamic biological environments and the limitations of current experimental methods, it remains challenging to simulate the motion mechanism, functional implementation strategy, and adaptability of MNRs in dynamic environments. Finite element analysis (FEA) plays an important role in MNR research; thorough review of state‐of‐the‐art research on MNRs. FEA is used to simulate MNRs motion mechanism, and theoretical models combined with experimental results are proposed to explain the motion mechanism. FEA can reduce the error rate of experiments. Combined with the simulation results, the optimal scheme is selected for experiments, and a reliable design strategy of MNRs is obtained. FEA has become a more effective method to obtain the optimal design of MNRs for in vivo applications. Therefore, herein, the design and driving mechanism of MNRs, the different solutions proposed for complex dynamic environments, and the use of FEA in the related research are introduced by this review. The current challenges and future research directions of FEA combined with external field‐driven MNRs are summarized.

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Section: Fea Of Mnr Designmentioning

confidence: 99%

Advances in Finite Element Analysis of External Field‐Driven Micro/Nanorobots: A Review

Liu

Feng

et al. 2023

Advanced Intelligent Systems

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“…The translational and rotational motion of these particles have been used to characterize the micromechanical properties of colloid glassy systems ( Lozano et al, 2019 ). More recently, bio-hybrid micromotors which couple synthetic structures with biological components have drawn particular interest for their multifunctionality and biocompatibility ( Schwarz et al, 2017 ; Quashie et al, 2022 ). For example, sperm have been incorporated into the design of micro swimmers to improve their mobility.…”

Section: Summary and Future Prospectsmentioning

confidence: 99%

Passive and Active Microrheology for Biomedical Systems

Mao

Nielsen

Ali

2022

Front. Bioeng. Biotechnol.

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Microrheology encompasses a range of methods to measure the mechanical properties of soft materials. By characterizing the motion of embedded microscopic particles, microrheology extends the probing length scale and frequency range of conventional bulk rheology. Microrheology can be characterized into either passive or active methods based on the driving force exerted on probe particles. Tracer particles are driven by thermal energy in passive methods, applying minimal deformation to the assessed medium. In active techniques, particles are manipulated by an external force, most commonly produced through optical and magnetic fields. Small-scale rheology holds significant advantages over conventional bulk rheology, such as eliminating the need for large sample sizes, the ability to probe fragile materials non-destructively, and a wider probing frequency range. More importantly, some microrheological techniques can obtain spatiotemporal information of local microenvironments and accurately describe the heterogeneity of structurally complex fluids. Recently, there has been significant growth in using these minimally invasive techniques to investigate a wide range of biomedical systems both in vitro and in vivo. Here, we review the latest applications and advancements of microrheology in mammalian cells, tissues, and biofluids and discuss the current challenges and potential future advances on the horizon.

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“…1–3 These minuscule robotic systems possess distinctive capabilities that enable them to access confined spaces and execute intricate tasks with minimal disruption to their surrounding environments. 4–7 Compared with light field drive and electric field drive, 8,9 magnetically controlled microrobots stand out due to their inherent advantages, such as wireless actuation, non-invasive control, reduced size and complexity, and improved adaptability. 10–14…”

Section: Introductionmentioning

confidence: 99%

Combined three dimensional locomotion and deformation of functional ferrofluidic robots

Fan,

Zhang,

et al. 2023

Nanoscale

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Magnetic bio-hybrid micro actuators

Abstract: Over the past two decades, there has been a growing body of work on wireless devices that can operate on the length scales of biological cells and even smaller. A...

Cited by 22 publications

References 136 publications

Advances in Finite Element Analysis of External Field‐Driven Micro/Nanorobots: A Review

Advances in Finite Element Analysis of External Field‐Driven Micro/Nanorobots: A Review

Passive and Active Microrheology for Biomedical Systems

Combined three dimensional locomotion and deformation of functional ferrofluidic robots

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