Magnetic and transport properties of magneto-anisotropic nanocomposites for controlled drug delivery

Bychkova, A. V.; Иорданский, А. Л.; Kovarski, Alexander L.; Sorokina, O. N.; Kosenko, R. Yu.; Markin, V. S.; Филатова, А. Г.; Гумаргалиева, К. З.; Роговина, С. З.; Berlin, A. A.

doi:10.1134/s199507801502007x

Cited by 20 publications

(9 citation statements)

References 51 publications

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“…For the cylindrical fibers, X f is the fiber diameter, while for Lw , in accordance with the Mackie–Meares equation, the correction for the increasing in the drug diffusion path due to the mat tortuosity was chosen as

{L w = true[(1 + {normalφ}_{normalf}) / true(1 - φ_{f} true) true]}^{2} {normalL}_{normalM},

where ϕ f is the volume fraction of polymer fibers in the mat. This correction was previously used to describe the drug diffusion in the PHB magnetic composites with the magnetite nanoparticles forming the extended aggregates …”

Section: Resultsmentioning

confidence: 99%

“…Describing the two‐stage diffusion as a drug transport in the quasi two‐layer medium with two different diffusion coefficients in accordance with the Crank simplification, the D eff can be presented as

L_{M} / true(D_{normale normalf normalf} true) = X_{f} / D_{f} + L_{w} / D_{w}

where X f , L w , and L M are the averaged geometric characteristics of drug diffusion path in the fibers, the interfibrous space, and the effective thickness of mats. For the cylindrical fibers, X f is fiber diameter, while for L w , in accordance with the Mackie–Mears equation, the correction for increasing in the drug diffusion path was chosen as

{L w = true[(1 + {normalφ}_{normalf}) / true(1 - φ_{f} true) true]}^{} {normalL}_{normalM},

where ϕ f is the volume fraction of polymer fibers. This correction was previously used to describe the drug diffusion in the PHB magnetic composites with the magnetite nanoparticles forming the extended aggregates …”

Section: Resultsmentioning

confidence: 99%

“…This correction was previously used to describe the drug diffusion in the PHB magnetic composites with the magnetite nanoparticles forming the extended aggregates. [24] In a PLA/PHB fibrilar mat prepared as rectangular parallelepiped consisted of disordered entangled fibers, D eff is determined by two consecutive processes such as the drug diffusion in the inherent fiber volume with diffusivity, D f , and the drug diffusional transport in the interfibrillar space of the mat that is filled by aqueous solvent (D W ). Describing the twostage diffusion as a drug transport in the quasi two-layer medium with two different diffusion coefficients in accordance with the Crank simplification, [23] the D eff can be presented as…”

Section: Macromolecular Symposiamentioning

confidence: 99%

“…where X f , L w , and L M are the averaged geometric characteristics of drug diffusion path in the fibers, the interfibrous space, and the effective thickness of mats. For the cylindrical fibers, X f is fiber diameter, while for L w , in accordance with the Mackie-Mears equation, [24] the correction for increasing in the drug diffusion path was chosen as…”

Section: Macromolecular Symposiamentioning

confidence: 99%

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Comparative Characterization of Melt Electrospun Fibers and Films Based on PLA‐PHB Blends: Diffusion, Drug Release, and Structural Features

Liu

Cao

Карпова

et al. 2018

Macromolecular Symposia

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Comparative structural‐dynamic characterization of the biopolyester blends based on poly(3‐hydroxybutyrate) and poly‐L‐lactide (PLA) [PHB/PLA] is performed. The melt electrospun fibers and molded films with the same compositions (1/0, 1/9, 3/7) but obtained by two different fabrication ways are explored by combination of structural and dynamic methods. The structural‐dynamic features such as segmental mobility (by spin‐probe ESR technique), thermophysical transitions (by DSC), and surface morphology (by SEM) are applied to elucidate the distinctive diffusion features as the essential constituent of drug release. The ultrathin electrospun fibers and molded films loaded by dipyridamole (DPD), as a modeling drug, shows the different structural behavior including crystallinity and the diversity in diffusion coefficients and the drug release profiles. To emphasize the special transport phenomena in nano‐sized drug vehicles, the diffusivity modeling is performed and further the drug diffusion coefficients in the ultrathin fibers and the macroscopic films are compared.

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{L w = true[(1 + {normalφ}_{normalf}) / true(1 - φ_{f} true) true]}^{2} {normalL}_{normalM},

Section: Resultsmentioning

confidence: 99%

L_{M} / true(D_{normale normalf normalf} true) = X_{f} / D_{f} + L_{w} / D_{w}

{L w = true[(1 + {normalφ}_{normalf}) / true(1 - φ_{f} true) true]}^{} {normalL}_{normalM},

Section: Resultsmentioning

confidence: 99%

Section: Macromolecular Symposiamentioning

confidence: 99%

Section: Macromolecular Symposiamentioning

confidence: 99%

See 2 more Smart Citations

Comparative Characterization of Melt Electrospun Fibers and Films Based on PLA‐PHB Blends: Diffusion, Drug Release, and Structural Features

Liu

Cao

Карпова

et al. 2018

Macromolecular Symposia

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show abstract

“…P(R)-HB [93][94][95][96][97], and bacterial copolymers such as P(3HB-co-4HB) [98][99][100], PHBV [101][102][103] or PHBH and derivatives [104][105][106], have been used for the elaboration of self-assembled systems such as DDSs, tissue engineering scaffolds and implants [107][108][109][110]. Those polymers have been chosen for their biodegradability and biocompatibility.…”

Section: Chemically Modified Bacterial Phb-based (Co)polymersmentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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PLLA-PHB fiber membranes obtained by solvent-free electrospinning for short-time drug delivery

Cao

Liu

Olkhov

et al. 2017

Drug Deliv. and Transl. Res.

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Fibers of poly(L-lactic acid) (PLLA)/polyhydroxybutyrate (PHB) with different concentrations of the drug dipyridamole (DPD) were prepared using solvent-free melt electrospinning to obtain a polymeric drug delivery system. The electrospun fibers were morphologically, structurally, thermally, and dynamically characterized. Crazes that resemble lotus root crevices were interestingly observed in the 7:3 PLLA/PHB fibers with 1% DPD. The crystallinity of PLLA slightly decreased as PHB was incorporated, and the addition of DPD significantly reduced the melting temperature of the composite. The interactions between PLLA and PHB mainly occurred at a proportion of 7:3, and drug encapsulation in the fibers was verified. The kinetic profiles of drug release demonstrated the predominant multiple patterns involving a diffusional stage in the short-term mode of release and kinetic process related to the hydrolysis of the biopolymers. Furthermore, the dynamic behavior of the polymer molecules was evaluated based on the segmental mobility using probe electron spin resonance spectroscopy. The segmental mobility in the amorphous fraction of PLLA decreased with increasing PLLA content. The 9:1 PLLA/PHB system was more resistant to polymer hydrolysis than to the 7:3 system and the rate of diffusion transport was approximately two times higher for the 7:3 PLLA/PHB fibers than for the 9:1 PLLA/PHB fibers.

show abstract

Magnetic and transport properties of magneto-anisotropic nanocomposites for controlled drug delivery

Cited by 20 publications

References 51 publications

Comparative Characterization of Melt Electrospun Fibers and Films Based on PLA‐PHB Blends: Diffusion, Drug Release, and Structural Features

Comparative Characterization of Melt Electrospun Fibers and Films Based on PLA‐PHB Blends: Diffusion, Drug Release, and Structural Features

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

PLLA-PHB fiber membranes obtained by solvent-free electrospinning for short-time drug delivery

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