Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe3O4 core–shell nanoparticles

Abstract

Among the number of hyperthermia materials, magnetic nanoparticles have received much attention. In this work, we studied the heating characteristics of uniform Fe@Fe 3 O 4 core-shell nanoparticle under near-infrared laser irradiation and external AC magnetic field applying. The Fe@Fe 3 O 4 core-shell nanoparticles were prepared by thermal decomposition of iron pentacarbonyl and followed by controlled oxidation. The prepared uniform particles were further coated with dimercaptosuccinic acid to make them well dispersed in water. Near-infrared derived photothermal study of solutions containing a different concentration of the core-shell nanoparticles was made by using 808 nm laser Source. Additionally, magnetic hyperthermia ability of the Fe@Fe 3 O 4 nanoparticle at 150 kHz and various oersted (140-180 Oe) condition was systemically characterized. The Fe@Fe 3 O 4 nanoparticles which exhibited effective photo and magnetic hyperthermia are expected to be used in biomedical application.

Photothermal ablation of murine melanomas by Fe3O4 nanoparticle clusters

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Cancer nanotechnology: current status and perspectives

“…Hyperthermia (localized heat to kill cells) is a promising method for elimination of cancerous tissue, and certain nanomaterials have been shown to enhance hyperthermal effects [ 355 , 356 ]. Uniform and selective hyperthermia can be achieved using nanomaterials with a high-absorption cross-section, which can convert an external energy source into heat [ 357 , 358 ]. Dynamic nanomaterials can achieve maximum therapeutic effects through multi-modal cancer treatments.…”

Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

“…The dimercaptosuccinic acid, possessing two carboxyl groups and two sulfhydryl groups, has been widely utilized as a stabilizing agent for the surface functionalization of IONPs. The process of DMSA coating gives water dispersivity to the NPs for biomedical purposes such as target‐specific delivery and hyperthermia 95,96 . Dopamine, as a versatile anchor, can facilitate the conjugation of biomolecules with IONPs 97 .…”

“…The process of DMSA coating gives water dispersivity to the NPs for biomedical purposes such as target-specific delivery and hyperthermia. 95,96 Dopamine, as a versatile anchor, can facilitate the conjugation of biomolecules with IONPs. 97 Cyclodextrin, as a biocompatible and cheap molecule for IOPNs coating, can enhance the stability and dispersion of IONPs in water and aqueous solutions.…”