Magnetic and hydrophilic MWCNT/Fe composites as potential T2-weighted MRI contrast agents

Maciejewska, Barbara M.; Warowicka, Alicja; Baranowska‐Korczyc, Anna; Załęski, Karol; Zalewski, Tomasz; Kozioł, Krzysztof; Jurga, Stefan

doi:10.1016/j.carbon.2015.07.091

Cited by 21 publications

(21 citation statements)

References 29 publications

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“…The freeze-drying process used here depends on freezing the gel with the remaining liquid and following this process sublimation, which is controlled by decreased pressure above the sample. The prior freezing process can determine the pore structure [23][24][25][26], which will further influence the specific surface area, adsorption [27], mechanical strength, electrical conductivity and magnetic properties [28,29]. Figure 2a presents prGO hydrogels obtained via sol-gel technique.…”

Section: Partially Reduced Graphene Oxide Aerogelmentioning

confidence: 99%

“…The EPR signals shape, intensity, g factor, linewidth, spin concentration is source of large number of information about local site symmetry, local dynamic and electron relaxation [50]. EPR study of graphene and graphene-related materials gives an important information about interactions and magnetism sources like defects, not passivated magnetic moments on edges, surface adatoms with unpaired magnetic moments, conduction electrons, and also remaining metal ion contamination [28,[51][52][53][54][55][56][57][58][59]. Unpaired electrons located on edges, on/in the graphene surface, are extremely sensitive to external conditions like atmosphere (oxygen, helium and vacuum) or moisture influencing the localization of Figure 7 Raman spectra of the reference and TMi-doped prGO aerogels.…”

Section: Epr Spectroscopy Of Tmi-doped Prgo Aerogelsmentioning

confidence: 99%

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Preparation and characterization of partially reduced graphene oxide aerogels doped with transition metal ions

et al. 2018

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This work presents the preparation and characterization of pristine and transition metal doped partially reduced graphene oxide aerogels. The step-by-step preparation of aerogels from graphene oxide with an assistance of VCl 3 , CrCl 3 , FeCl 2 Á4H 2 O, CoCl 2 , NiCl 2 and CuCl 2 chlorides as reducing agents is shown and explained. The influence of reducing agents on the structural and magnetic properties of prepared aerogels is investigated. The use of electron paramagnetic resonance in purification during synthesis of GO and characterization afterwards is shown. It was found that VCl 3 was the strongest reducing agent leading to the formation of the most dense reduced graphene oxide aerogel, whereas vanadium is visible in EPR spectrum in form of V 4? complex as a VO 2?groups.

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Section: Partially Reduced Graphene Oxide Aerogelmentioning

confidence: 99%

Section: Epr Spectroscopy Of Tmi-doped Prgo Aerogelsmentioning

confidence: 99%

Preparation and characterization of partially reduced graphene oxide aerogels doped with transition metal ions

et al. 2018

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“…MRI contrast agents are classified into two classes: spin-lattice relaxation agents, with larger effects on T 1 shortening and spin-spin relaxation agents with larger effects on T 2 shortening, where T 1 and T 2 are the proton relaxation times. In order to produce an MRI-active CNT CA, a paramagnetic or superparamagnetic agent must be conjugated to or encapsulated within the CNT platform [76,77]; moreover, a proper agent is needed to target tumors [78,79,80]. Recently, Liu et al placed, inside the inner cavity of MWCN SuperParamagnetic Iron Oxide (SPIO), nanoparticles to create a T 2 -weighted contrast agent.…”

Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

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“…The sample with 2 wt.% of Fe provided the strongest contrasting results and it is cytotoxic for HeLa cell lines was negligible. Therefore, O-MWCNT-Fe nanocomposites can be introduced as a promising CA for cancer imaging [122].…”

Section: Mrimentioning

confidence: 99%

Magnetic carbon nanotubes: preparation, physical properties, and applications in biomedicine

Samadishadlou

Farshbaf²,

Annabi

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Magnetic carbon nanotubes (MCNTs) have been widely studied for their potential applications in medicine, diagnosis, cell biology, analytical chemistry, and environmental technology. Introduction of MCNTs paved the way for the emergence of new approaches in nanobiotechnology and biomedicine as a result of their multifarious properties embedded within either the carbon nanotubes (CNTs) or magnetic parts. Numerous preparation techniques exists for functionalizing CNTs with magnetic nanoparticles, and these versatile strategies lay the ground for the generation of novel and versatile systems which are applicable to many industries and biological areas. Here, we review and discuss the recent papers dealing with MCNTs and their application in biomedical and industrial fields.

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Magnetic and hydrophilic MWCNT/Fe composites as potential T2-weighted MRI contrast agents

Cited by 21 publications

References 29 publications

Preparation and characterization of partially reduced graphene oxide aerogels doped with transition metal ions

Preparation and characterization of partially reduced graphene oxide aerogels doped with transition metal ions

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Magnetic carbon nanotubes: preparation, physical properties, and applications in biomedicine

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