This paper proposes a scheme of image granulation by f u u y inference technique. For a region of interests(RO1) in a medical image, we describe knowledge needed to granulate the ROI, for example, knowledge of intensity, knowledge of location and so on. Generally, we cannot granulate the ROI without employing the whole of the knowledge. Fuzzy inference rules of the derived knowledge can accommodate the granulation. After the inference results are compiled to a total degree, a resultant data is obtained. Clustering or region growing technique is used to granulate the ROI. The experimental results on human brain MR images and human foot CT images show that our method can precisely granulate the ROI.