Magnesium, zinc and calcium aluminium layered double hydroxide-drug nanohybrids: A comprehensive study

Saha, Suman; Ray, Sayantan; Acharya, Rituparna; Chatterjee, Tapan K.; Chakraborty, Jayanta

doi:10.1016/j.clay.2016.09.030

Cited by 70 publications

(22 citation statements)

References 183 publications

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“…Toxicity was found to vary depending on the chemical composition and concentration of LDH and cell line . Table gives the toxicological effect of various LDH.…”

Section: Ldh and Biological Cell Interactionsmentioning

confidence: 99%

Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials

Forano

Bruna

Mousty

et al. 2018

The Chemical Record

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This review highlights the current research on the interactions between biological cells and Layered Double Hydroxides (LDH). The as-prepared biohybrid materials appear extremely attractive in diverse fields of application relating to health care, environment and energy production. We describe how thanks to the main features of biological cells and LDH layers, various strategies of assemblies can be carried out for constructing smart biofunctional materials. The interactions between the two components are described with a peculiar attention to the adsorption, biocompatibilization, LDH layer internalization, antifouling and antimicrobial properties. The most significant achievements including authors' results, involving biological cells and LDH assemblies in waste water treatment, bioremediation and bioenergy generation are specifically addressed.

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“…Toxicity was found to vary depending on the chemical composition and concentration of LDH and cell line . Table gives the toxicological effect of various LDH.…”

Section: Ldh and Biological Cell Interactionsmentioning

confidence: 99%

Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials

Forano

Bruna

Mousty

et al. 2018

The Chemical Record

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“…Eventually, the Fe 3 O 4 /LDHs photocatalyst must have a good photo corrosion resistance ability and must be stable at room temperature few days. Some review articles are available on individual LDHs and magnetic iron nanoparticle that focus on the preparation and their catalytic applications [38][39][40][41][42][43]. Daud et al was studied graphene/layered double hydroxides nanocomposites evaluated the research progress and new developments in the area [44].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Fe3O4 based layered double hydroxides (LDHs) nanocomposites (Fe3O4/LDHs): recent review of progress in synthesis, properties and applications

2018

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In view of the previous work on magnetic Fe 3 O 4 nanoparticles-based layered double hydroxides (magnetic Fe 3 O 4 /LDHs) as novel photocatalyst, research on this group of composites became one of the most attractive topics of nowadays. The magnetic Fe 3 O 4 /LDHs materials are often utilized for environmental remediation and photocatalysis. Hybrids of layered double hydroxides (LDHs) and Fe 3 O 4 MNPs are efficient nanocomposites due to their flexible properties and the excess of composition available for modification. So, critically reviews on the hybrid of the work magnetic Fe 3 O 4 /LDHs composite are the first report that efficient nanocomposites because of their flexible properties, energy and time used for separation, reduced consumption of additional materials can result in significant environmental and economic benefits. "The electrostatic interaction between the positively charged LDHs nanocomposites and negatively charged Fe 3 O 4 MNPs is adequate to make the formation of stable self-assembly of the two components". This review article discussed the magnetic Fe 3 O 4 /LDHs nanocomposites synthesis and applications in the photo catalysis, drug delivery and environmental remediation.

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“…The role of MgAl‐layered double hydroxide (MgAl‐LDH) as drug delivery vehicle has long been explored for various applications specifically in cancer although, as prepared, the anticancer property of LDH nanoparticles has never been reported. In this regard, it is important to note that, alongwith anticancer drug, the anticancer property of its carrier, might exhibit a synergistic anticancer efficacy, leading to an enhanced action of the drug delivery nanoconjugate.…”

Section: Introductionmentioning

confidence: 99%

“…On account of the lesser solubility of the alkaline-earth metals down the group II, the possibility of precipitation of the more electropositive calcium ion is much higher compared to the magnesium ion and herewith, close match with the charge and radius of the ionic species (impurity ion, e.g., CO 3 2À ion) also play a major role. 14 The role of MgAl-layered double hydroxide (MgAl-LDH) as drug delivery vehicle has long been explored for various applications 15,16 specifically in cancer [17][18][19][20] although, as prepared, the anticancer property of LDH nanoparticles has never been reported. In this regard, it is important to note that, alongwith anticancer drug, the anticancer property of its carrier, might exhibit a synergistic anticancer efficacy, leading to an enhanced action of the drug delivery nanoconjugate.…”

Section: Introductionmentioning

confidence: 99%

pH‐dependent facile synthesis of CaAl‐layered double hydroxides and its effect on the growth inhibition of cancer cells

et al. 2018

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The present communication reports a pH‐dependent facile synthesis of calcium aluminum layered double hydroxide (CaAl‐LDH), at 3 different pH conditions of 8.5, 10.5 and 12.5 respectively, by simple coprecipitation route that led to the precipitation of the same in phase pure or in mixed phase form, and their detail characterization. Interestingly, at a pH of 8.5, the precipitate obtained was 100% phase pure CaAl‐LDH, represented as sample A, whereas, at higher pH conditions, a mixed phase comprising 37% of a combination of CaCO3 polymorphs, e.g., calcite and aragonite and 63% of the CaAl‐LDH (at pH 10.5, represented as sample B) and 43% of a combination of calcite and aragonite and the rest 57% being CaAl‐LDH (at pH 12.5, represented as sample C) respectively, were obtained. The increasing trend of the presence of carbonate anion (with reference to calcite and aragonite phases) was estimated by trace level ion‐exchange chromatography study using organic acid column. All the above samples were tested for their anticancer activity in vitro, using cancer cell lines, e.g., human colon carcinoma (HCT116) and human breast adenocarcinoma (MCF7). Interestingly, sample A only exhibited significant growth inhibition of the cancer cells as above‐mentioned. The observation as above was verified using human osteoblast precursor cells (MC3T3) as well, on which, all the samples (sample A, sample B and sample C) exhibited good cellular viability.

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Magnesium, zinc and calcium aluminium layered double hydroxide-drug nanohybrids: A comprehensive study

Cited by 70 publications

References 183 publications

Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials

Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials

Magnetic Fe3O4 based layered double hydroxides (LDHs) nanocomposites (Fe3O4/LDHs): recent review of progress in synthesis, properties and applications

pH‐dependent facile synthesis of CaAl‐layered double hydroxides and its effect on the growth inhibition of cancer cells

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