Magnesium Transporter MgtA revealed as a Dimeric P-type ATPase
Rilee Zeinert,
Fei Zhou,
Pedro Franco
et al.
Abstract:Magnesium (Mg2+) uptake systems are present in all domains of life given the vital role of this ion. Bacteria acquire Mg2+ via conserved Mg2+ channels and transporters. The transporters are required for growth when Mg2+ is limiting or during bacterial pathogenesis, but, despite their significance, there are no known structures for these transporters. Here we report the first structure of the Mg2+ transporter MgtA solved by single particle cryo-electron microscopy (cryo- EM). Using mild membrane extraction, we … Show more
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