Magnesium therapy improves thromboelastographic findings before liver transplantation: A preliminary study

Choi, Jong Ho; Lee, Jaemin; Park, Chong Myung

doi:10.1007/bf03027721

Cited by 26 publications

(21 citation statements)

References 14 publications

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“…2007). Conversely, however, the IV administration of MgSO 4 significantly improved thromboelastography (TEG) variables in human patients with a hypocoagulable state and undergoing liver transplantation (Choi et al. 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

Rioja

Dzikiti

Fosgate

et al. 2012

Veterinary Anaesthesia and Analgesia

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Section: Introductionmentioning

confidence: 99%

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

Rioja

Dzikiti

Fosgate

et al. 2012

Veterinary Anaesthesia and Analgesia

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“…In situation of rapid intravenous fluid infusion, maintaining magnesium at the upper limit of normal value attenuates rapid hemodilution-induced coagulation change (clot formation rate prolongation) due to decreased magnesium level in healthy volunteers [5]. Magnesium significantly improves the hypocoagulable state toward normal in patients undergoing liver transplantation [6]. However, James and Neil [7] reported that magnesium has minimal effects on coagulation (small prolongation of r time and k time and r + k time at thromboelastography) and Ames et al [8] reported that magnesium levels remained unchanged except for an increase of the α angle at thromboelastography in healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

The effects of magnesium on the course of atrial fibrillation and coagulation in patients with atrial fibrillation undergoing mitral valve annuloplasty

Kang

Yun

Han

et al. 2011

Korean J Anesthesiol

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BackgroundAtrial fibrillation (AF) is the most common cardiac arrhythmia. Magnesium has been reported to be effective in reducing the incidence or prophylaxis of AF. Magnesium is also an essential constituent of many enzyme systems and plays a physiological role in coagulation regulation. The aim of the present study was to examine the effects of magnesium, whether magnesium infusion might decrease the incidence of AF and induce hypocoagulable state in patients with AF, who were undergoing mitral valve annuloplasty.MethodsThis prospective laboratory study was performed using blood from patients with AF undergoing mitral valve annuloplasty. The radial artery was punctured with a 20 gauge catheter and used for monitoring continuous arterial pressure and blood sampling. After anesthesia induction, 4 g of magnesium was mixed with 100 ml normal saline and infused for 5 minutes. Magnesium, calcium, activated clotting time (ACT) and thromboelastographic parameters were checked before and 60 minutes after the magnesium infusion. The electrocardiography changes after magnesium infusion were also checked before commencing cardiopulmonary bypass.ResultsAfter magnesium infusion, the serum level of magnesium increased significantly but serum calcium did not change significantly. ACT did not change significantly before or after magnesium infusion. The thromboelastographic parameters showed no significant changes before or after magnesium infusion. None of the patients converted to sinus rhythm from AF after the magnesium infusion.ConclusionsA magnesium infusion did not influence the course of AF and coagulation in patients during prebypass period with AF undergoing mitral valve annuloplasty.

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“…Magnesium is usually given in amount of 2 g intravenously over 30 min to correct hypomagnesemia [10]. In the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) [7], patients with acute myocardial infarction randomly received magnesium 2 g or placebo over 5 min, before thrombolytic therapy, followed by 16 g as infusion over the next 24 h. Serum magnesium concentrations were approximately doubled for 24 h and returned to normal by 48 h. In a previous study [26], when 1.5 g of magnesium sulfate mixed in 100 ml of normal saline was infused, the magnesium concentration increased within the normal range during LDLT. From these results, we selected the dose (25 mg/kg) of magnesium sulfate because the administration of 1.5 to 2 g of magnesium to patients of 60 to 70 kg corresponds to 25 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

The effects of magnesium pretreatment on reperfusion injury during living donor liver transplantation

Kim

Jeon

et al. 2011

Korean J Anesthesiol

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BackgroundIschemia reperfusion (IR) injury is a complex phenomenon that leads to organ dysfunction and causes primary liver failure following liver transplantation. We investigated whether an intravenous administration of magnesium before reperfusion can prevent or reduce IR injury.MethodsFifty-nine living donor liver transplant recipients were randomly assigned to an MG group (n = 31) or an NS group (n = 28). Each group was also divided in two groups based on the preoperative magnesium levels (normal: ≥ 0.70 mmol/L, low: < 0.70 mmol/L). The MG groups received 25 mg/kg of MgSO4 mixed in 100 ml normal saline intravenously before reperfusion and the NS groups received an equal volume of normal saline. The levels of lactate, pH, arterial oxygen tension, and base excess were measured to assess reperfusion injury at five specific times, which were 10 min after the beginning of anhepatic phase, and 10, 30, 60 and 120 min after reperfusion. To evaluate postoperative organ function, the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and creatinine levels were measured at preoperative day 1, postoperative day 1 and 5.ResultsThe blood lactate levels were significantly lower at 10, 30, 60 and 120 min after reperfusion in the MG groups compared to the NS groups. In addition, significantly higher blood lactate levels were observed in the NS group with preoperative hypomagnesemia than in MG groups.ConclusionsMagnesium administration before reperfusion of liver transplantation significantly reduces blood lactate levels. These findings suggest that magnesium treatment may have protective effects on IR injury during living donor liver transplantation.

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Magnesium therapy improves thromboelastographic findings before liver transplantation: A preliminary study

Cited by 26 publications

References 14 publications

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing ovariohysterectomy

The effects of magnesium on the course of atrial fibrillation and coagulation in patients with atrial fibrillation undergoing mitral valve annuloplasty

The effects of magnesium pretreatment on reperfusion injury during living donor liver transplantation

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