Magnesium — The forgotten electrolyte

Geiderman, Joel M.; Goodman, Steven L.; Cohen, Don B.

doi:10.1016/s0361-1124(79)80128-8

Cited by 10 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the hyperparathyroid state, a negative magnesium balance occurs as a result of the mobilisation of magnesium along with calcium from the bones, with a concomitant increase in the urinary excretion of this ion. Other reports on hypomagnesaemia (Hall & Joffe, 1973;Geiderman et a!, 1979) emphasise organic mental symptoms, particularly deficits in spatial conceptuali sation, and the well-known manifestations of neuro muscular irritability. Hallucinations are predominant ly visual, but a systematised paranoid psychosis is rare.…”

Section: Pathophysiological Issuesmentioning

confidence: 95%

“…Hallucinations are predominant ly visual, but a systematised paranoid psychosis is rare. Nevertheless, the notion of magnesium playing a,role in the development of psychotic symptoms is appealing because of its close interactions with acetylcholine and calcium (Hall & Joffe, 1973;Geiderman et a!, 1979;Massey, 1978). Another interesting problem is the possibility of co-existing abnormalities in the function ing of more than one gland, as documented by Feldman et al's case (1968), which distorts the symptoms of the co-existing disorders and may confuse the approach to diagnosis.…”

Section: Pathophysiological Issuesmentioning

confidence: 99%

See 1 more Smart Citation

Hyperparathyroidism and Paranoid Psychosis

Alarcón

Franceschini

1984

Br J Psychiatry

View full text Add to dashboard Cite

Literature on psychiatric manifestations of hyperparathyroidism published in the last four decades confirms the unusual features of a case of paranoid psychosis secondary to a parathyroid-adenoma-induced hypercalcaemia. Affective and organic symptoms are overwhelmingly dominant in hypercalcaemic patients; the majority of cases reported are women of 50 years or older, who have been vaguely ill for a prolonged time before the actual endocrinopathy appears. The severity of the psychiatric symptoms does not seem to be related to the degree of hypercalcaemia. Recent findings link the role of calcium and related ions in the production of psychopathological symptoms to membrane phenomena, dopaminergic activity, and neuroendocrine regulation.

show abstract

Section: Pathophysiological Issuesmentioning

confidence: 95%

Section: Pathophysiological Issuesmentioning

confidence: 99%

Hyperparathyroidism and Paranoid Psychosis

Alarcón

Franceschini

1984

Br J Psychiatry

View full text Add to dashboard Cite

show abstract

“…Unfortunately, this is not easy to measure. This dilemma has led to magnesium being described variously as a "Cinderella element", the "forgotten electrolyte", or the "neglected cation" in biological systems (Frausto da Silva and Williams, 1991;Geiderman et al, 1979;Foy, 1980, respectively).…”

Section: B Physicochemical Status and Assessment Of Intracellular Mamentioning

confidence: 99%

The Roles of Magnesium in Biotechnology

Walker

1994

Critical Reviews in Biotechnology

115

View full text Add to dashboard Cite

This review highlights the important roles played by magnesium in the growth and metabolic functions of microbial and animal cells, and therefore assigns a key role for magnesium ions in biotechnology. The fundamental biochemical and physiological actions of magnesium as a regulatory cation are outlined. Such actions are deemed to be relevant in an applied sense, because Mg2+ availability in cell culture and fermentation media can dramatically influence growth and metabolism of cells. Manipulation of extracellular and intracellular magnesium ions can thus be envisaged as a relatively simplistic, but nevertheless versatile, means of physiological cell engineering. In addition, biological antagonism between calcium and magnesium at the molecular level may have profound consequences for the optimization of biotechnological processes that exploit cells. In fermentation, for example, it is argued that the efficiency of microbial conversion of substrate to product may be improved by altering Mg:Ca concentration ratios in industrial feedstocks in a way that makes more magnesium available to the cells. With particular respect to yeast-based biotechnologies, magnesium availability is seen as being crucially important in governing central pathways of carbohydrate catabolism, especially ethanolic fermentation. It is proposed that such influences of magnesium ions are expressed at the combined levels of key enzyme activation and cell membrane stabilization. The former ensures optimum flow of substrate to ethanol and the latter acts to protect yeasts from physical and chemical stress.

show abstract

“…3 and "The forgotten electrolyte." 4 Hypomagnesaemia is common in critically ill patients, and there is strong, consistent clinical evidence, largely from observational studies showing that hypomagnesaemia is significantly associated with increased need for prolonged ICU stay and increased mortality.…”

Section: Introductionmentioning

confidence: 99%

Study of Serum Magnesium Levels in Critically Ill Patients

Elenjickal¹,

Lakra²

2017

jemds

View full text Add to dashboard Cite

BACKGROUNDMagnesium is the fourth most abundant cation in the body. Hypomagnesaemia is common in critically ill patients, and there is strong, consistent clinical evidence that it is associated with increased need for mechanical ventilation, prolonged ICU stay and increased mortality. There is a current need to expand our knowledge with regards to magnesium homeostasis and its impact on survival and prognosis of critically ill patients. Aims and Objectives-To study the serum total magnesium in critically ill patients and to assess the primary critical medical conditions associated with abnormalities of serum magnesium and to correlate serum magnesium levels with patient outcome in terms of length of stay and mortality.

show abstract

Magnesium — The forgotten electrolyte

Cited by 10 publications

References 27 publications

Hyperparathyroidism and Paranoid Psychosis

Hyperparathyroidism and Paranoid Psychosis

The Roles of Magnesium in Biotechnology

Study of Serum Magnesium Levels in Critically Ill Patients

Contact Info

Product

Resources

About