Magnesium supplementation in pregnancy

Spätling, L.; Fallenstein, F.

doi:10.1016/s0002-9378(11)90707-8

Cited by 7 publications

(10 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association of a low dietary Mg intake and an increased risk of PE has also been confirmed in a meta-analysis studying the effects of various dietary factors on the risk of pregnancy-induced high BP [ 31 ]. Spätling et al concluded in a review on Mg and pregnancy that the need for Mg intake increases during pregnancy, with a daily recommended dose of supplemented Mg of 240–480 mg [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study

Bullarbo

Mattson

Broman

et al. 2018

Journal of Pregnancy

View full text Add to dashboard Cite

Objective To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups. Methods Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo. Results There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure (p = 0.042). Magnesium supplementation seems to be safe for both mother and infant. Conclusion Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849.

show abstract

Section: Introductionmentioning

confidence: 99%

Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study

Bullarbo

Mattson

Broman

et al. 2018

Journal of Pregnancy

View full text Add to dashboard Cite

show abstract

“…This has led to the suggestion that a dietary deficiency in magnesium coupled with added requirements related to pregnancy may be etiologic factors in some of these conditions and, in addition, that dietary supplements of magnesium may be used for prophylaxis. 7 Past studies addressing the issue of magnesium supplementation in pregnancy have been hampered by being retrospective, 8 by comparing heterogeneous groups, 9 and possibly by inadequate dosing, with demonstration of only a slight elevation of serum magnesium levels in patients on magnesium therapy. 10 In addition, magnesium has never been measured in its free, biologically active form in such studies in pregnancy.…”

mentioning

confidence: 99%

Ionized Serum Magnesium Levels in Umbilical Cord Blood of Normal Pregnant Women at Delivery: Relationship to Calcium, Demographics, and Birthweight

Handwerker

Altura²,

Royo³

et al. 1993

Amer J Perinatol

View full text Add to dashboard Cite

Using a novel ion-selective electrode for ionized Mg (IMg2+), we sought to: (1) determine levels and fractions of IMg2+ in umbilical vessels of normal pregnant women: (2) determine their relationships with ionized calcium (ICa2+) levels: (3) determine whether any demographic or clinical parameters affect these levels of divalent cations: and (4) compare levels of IMg2+, total Mg, percent IMg2+, and ICa2+ with sera of normal pregnant and nonpregnant women. We obtained umbilical arterial and venous serum from 38 normal subjects and venous samples from 26 normal pregnant women and 42 nonpregnant women. The mean umbilical venous IMg2+ level (0.51 +/- 0.01 mmol/liter) was significantly greater than the umbilical arterial level (0.48 +/- 0.01 mmol/liter, p < 0.05), and the latter was similar to maternal venous levels (0.48 +/- 0.01 mmol/liter). The maternal venous mean value is 20% less than that found (0.60 +/- 0.005 mmol/liter) in peripheral serum of nonpregnant women. The ionized fractions were significantly (p < 0.01) higher in the umbilical veins than umbilical arteries, and the percent IMg2+ fractions were similar in umbilical arteries and maternal venous blood. IMg2+ levels were lower in multiparous patients and those who received epidural analgesia and higher in patients who had operative vaginal delivery and in Asians. Ionized fractions of Mg in umbilical veins were higher in large for gestational age infants. Our findings provide evidence of a Mg deficiency in pregnancy and suggest that measurement of IMg2+ may have clinical value for diagnosis and therapy of such deficiency.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Постійне гармонійне зростання плацентарної тканини з виділенням безлічі білків є результатом тонкого балансування між клітинною проліферацією та апоптозом. Порушення цього балансу може призвести до виникнення патології плаценти й дефектів розвитку ембріона [15,27].…”

Section: вступunclassified

Algorithm for the diagnosis and treatment of primary placental dysfunction in pregnant women of risk groups

Беленичев

2021

View full text Add to dashboard Cite

Research objective: to evaluate the effectiveness of diagnosis and complex therapy of placental dysfunction (PD) in early stages of gestation.Materials and methods. We examined 110 pregnant women with risk for the primary PD. Exclusion criteria were multiple pregnancies, anomalies of fetal development and internal genital organs of the mother, pregnancy resulting from assisted reproductive technologies.The diagnosis of PD was established in 56 women (group I) based on the assessing the state of extraembryonic structures and blood flow in the spiral and uterine arteries at 12–13 weeks of gestation. The rest of the patients (54 women) entered the control group without PD (group II).Results. All pregnant women with verified PD at 12–13 weeks were prescribed complex drug treatment, which included micronized progesterone, venotonic Normoven, Magnicum, and Artihol. As a result of treatment, already at 22–24 weeks of gestation, the average value of blood flow (resistance index) in the uterine and spiral arteries did not differ significantly in the groups. There was no significant difference in fetometry and placentometry indices at 35–36 weeks of gestation. Complications of the gestational period in patients in the study groups were also almost the same.Conclusions. History of hormonal disorders and miscarriage, clinical signs of miscarriage in early gestation, abnormal embryo placement, extragenital pathology, and genital tract infections are risk factors for PD. Determination of the state of extraembryonic structures at 7–8 weeks of pregnancy (ovum volume, blood flow in the corpus luteum) and at 12–13 weeks (chorion volume, vascularization index, blood flow in the spiral and uterine arteries) can serve as a verification criterion for the PD development. Complex drug therapy, which began from the early stages of gestation (micronized progesterone, Normoven, Magnicum, Artihol) has established itself as an effective method of treating primary PD in pregnant of risk groups.

show abstract

Magnesium supplementation in pregnancy

Cited by 7 publications

References 1 publication

Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study

Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study

Ionized Serum Magnesium Levels in Umbilical Cord Blood of Normal Pregnant Women at Delivery: Relationship to Calcium, Demographics, and Birthweight

Algorithm for the diagnosis and treatment of primary placental dysfunction in pregnant women of risk groups

Contact Info

Product

Resources

About