Magnesium sulphate versus dexmedetomidine as an adjuvant to local anesthetic mixture in peribulbar anesthesia

Mohamed, Ahmed Zein Elabdein; Genidy, Mahmoud

doi:10.1016/j.egja.2017.07.001

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…A recent study assessed the efficacy and safety of addition of dexmedetomidine versus magnesium sulphate to the local anesthetic mixture for peribulbar block in cataract surgery. Both the drugs enhanced the onset of globe anesthesia and akinesia with no significant changes in the hemodynamic measurements [22].…”

Section: Discussionmentioning

confidence: 90%

Effectiveness and Safety of Single Percutaneous Peribulbar Block Using Magnesium Sulphate as an Adjuvant to Local Anesthetics Versus the Standard Peribulbar Block for Strabismus Surgery in Adults

Sherif¹,

Mohamad²,

Taher³

et al. 2019

TOATJ

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Background: Peribulbar anesthesia in ophthalmic surgeries is limited by delayed and/or incomplete orbital akinesia and inadequate operative and postoperative analgesia. Objective: The aim of this study was to assess the safety and effectiveness of a single percutaneous peribulbar block technique with 100 mg magnesium sulphate added to the local anesthetics used compared with the standard peribulbar block technique in adult strabismus surgery. Methods: A total of 54 consecutive patients undergoing strabismus surgery were included in the study. They were divided into two equal groups (27 patients each). In group I, 1 ml (100 mg/ml) magnesium sulphate added to a mixture of 2 ml lidocaine 2%, 2 ml bupivacaine 0.5% and 1 ml hyaluronidase (150 units/ml) was administered through a single percutaneous peribulbar injection with a short (1 inch) needle, while in group II, a mixture of 1 ml saline added to 2 ml lidocaine 2%, 2 ml bupivacaine 0.5% and 1 ml hyaluronidase (150 units/ml) was administered using the standard peribulbar block technique. The collected data included patient's baseline characteristics, perioperative and early postoperative outcomes and follow-up data. Results: The elapsed time before the onset of anesthesia and akinesia of the globe was significantly shorter in group I compared with group II (1.9 ± 0.7 vs. 3.9 ± 1.0 min, p < 0.001; 2.3 ± 0.7 vs. 4.4 ± 1.2 min, p < 0.001 respectively), and the duration of anesthesia was significantly longer in group I compared with group II (180.0 ± 0.0 vs. 43.0 ± 8.5 min, p < 0.001). The median VAS pain score was significantly lower in group I compared with group II (1.0 vs. 4.0, p < 0.001), and the patient's satisfaction was significantly higher in group I compared with group II (100.0% vs. 25.9%, p < 0.001). Conclusion: Co-administration of 100 mg magnesium sulphate with the local anesthetics was effective and safe. It achieved suitable conditions to start surgery rapidly. Further, it improved the quality of operative conditions and patient satisfaction.

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Section: Discussionmentioning

confidence: 90%

Effectiveness and Safety of Single Percutaneous Peribulbar Block Using Magnesium Sulphate as an Adjuvant to Local Anesthetics Versus the Standard Peribulbar Block for Strabismus Surgery in Adults

Sherif¹,

Mohamad²,

Taher³

et al. 2019

TOATJ

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“…A comparable study assessed the effect of adding neostigmine 0.5 mg to local anesthetic mixture in peribulbar anesthesia for patients scheduled for trabeculectomy. Neostigmine improved the quality of surgical conditions where it accelerated the onset and prolonged the duration of sensory and motor blocks, delayed the time to first analgesic request, and increased satisfaction of the patients without any adverse effects [6]. As well, Kayalha et al [7] evaluated the analgesic efficacy and the safety of adding 25 µg neostigmine to 20 mg bupivacaine during spinal anesthesia in a randomized, controlled study involving patients scheduled for lower limb orthopedic surgery.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of adding different doses of neostigmine as an adjuvant in peribulbar block for cataract surgery: A randomized controlled trial

Fetouh

Sherif

Osama

et al. 2021

Egyptian Journal of Anaesthesia

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Background: This study aimed to evaluate safety and efficacy of adding two different doses of neostigmine to the local anesthetic lidocaine in peribulbar block anesthesia for cataract surgery. Methods: This randomized, double blind, parallel group, controlled trial (Trial registration number: IRCT20210106049952N1) included 60 patients (30-70 years-old), ASA physical status I, II, or III who were scheduled for cataract surgery. Patients received standard peribulbar block (Group C) or standard block plus 0.25 mg neostigmine (Group N25) or 0.5 mg neostigmine (Group N50). All patients were assessed for primary outcomes including hemodynamics and onsets of motor and sensory blocks. Secondary outcomes included duration of block, patient's and surgeon's satisfaction, postoperative pain, and time to first analgesic dose. Results: Mean onset of motor block was significantly shorter in N25 and N50 groups (72.25 ± 20.3 and 44.3 ± 10.4 sec, respectively) than in control group (110.25 ± 35.6 sec). Onset of sensory block was significantly shorter in N50 group compared to control group as well as N25 group (P < 0.001). A significantly longer mean duration of block was observed in N50 group (173.55 ± 31.09 min) in comparison to control group (79.75 ± 12.51 min) and N25 group (81.25 ± 6.25 min). Mean time till first analgesic dose showed significant differences between the three groups C, N25, and N50 (2.85 ± 0.47, 3.45 ± 1.28, and 7.1 ± 1.25 h, respectively, P < 0.001). Only two patients belonging to N50 group developed postoperative nausea and vomiting. Conclusion: Neostigmine in 0.5 mg was superior to 0.25 mg dose when added to the local anesthetic lidocaine in peribulbar anesthesia for cataract surgery regarding both sensory and motor block as well as postoperative analgesia.

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“…Those impact for organization about first mass of the magnesium when compared with organization from claiming 50 dexmedetomidine done peribulbar anesthesia ,it discovered that organization from claiming mg magnesium sulfate 10% or 25 mg dexmedetomidine should mixture for lidocaine 2% Also bupivacaine 0. 5% for peribulbar anesthesia to phacoemul-sification about waterfall Also intraocular lens implantation accelerated the onset the long haul for tangible block, globe akinesia, cover akinesia, Also time for suitableness states on start surgery Furthermore prolonged the span from claiming globe akinesia, cover akinesia, andtime will 1st pain relieving appeal [7]. Expansion for fentanyl (2 lg/ml) alternately magnesium sulfate (50 mg) to peribulbar square in patients undergoing waterfall surgery just as prolongs the span of postoperative absense of pain.…”

Section: Discussionmentioning

confidence: 99%

Evalution of the Effect of Addition of Magnesium Sulfate to Local Anesthetics for Peribulbar Block: a Meta-Analysis for Randomized Trials

Hamid

Khashaba

Aboelsaod

2020

Benha Journal of Applied Sciences

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Magnesium sulphate versus dexmedetomidine as an adjuvant to local anesthetic mixture in peribulbar anesthesia

Abstract: a b s t r a c t Ó 2017 Publishing services by Elsevier B.V. on behalf of Egyptian Society of Anesthesiologists. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cited by 8 publications

References 17 publications

Effectiveness and Safety of Single Percutaneous Peribulbar Block Using Magnesium Sulphate as an Adjuvant to Local Anesthetics Versus the Standard Peribulbar Block for Strabismus Surgery in Adults

Effectiveness and Safety of Single Percutaneous Peribulbar Block Using Magnesium Sulphate as an Adjuvant to Local Anesthetics Versus the Standard Peribulbar Block for Strabismus Surgery in Adults

Safety and efficacy of adding different doses of neostigmine as an adjuvant in peribulbar block for cataract surgery: A randomized controlled trial

Evalution of the Effect of Addition of Magnesium Sulfate to Local Anesthetics for Peribulbar Block: a Meta-Analysis for Randomized Trials

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