Magnesium Sulfate Reduces Intra- and Postoperative Analgesic Requirements

Koinig, Herbert; Wallner, Thomas; Marhofer, Peter; Andel, H.; Hörauf, K; Mayer, N.

doi:10.1097/00000539-199807000-00042

Cited by 158 publications

(179 citation statements)

References 13 publications

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“…Bolus dozunu takiben intraoperatif magnezyum infüz-yonunun uygulanmasıyla, postoperatif analjezi ihtiyacının azaldığını gösteren birçok çalışma vardır. [6][7][8][9] Bu çalışmalarda magnezyum 30-50 mg/kg bolus dozu takiben 8-15 mg/kg/saat aralığında infüzyon dozlarında kullanılmıştır. İnfüzyon yoluyla uzun sü-reli magnezyum kullanımının, hastanın yakın takibi ve uzun süre monitörizasyonunu gerektirdiğinden, pratik olarak rutinde kullanımının mümkün olamayacağı düşüncesiyle tek doz kullanmayı uygun gördük ve preoperatif 50 mg/kg magnezyum sülfa-tı en az 10 dakikada infüzyon şeklinde tek doz olarak verdik.…”

Section: Discussionunclassified

“…Koinig ve ark. [8] 50 mg/kg bolus ve 8 mg/kg/saat magnezyum uyguladıkları çalışmalarında, hemodinamik açıdan kontrol grubu ile aralarında fark bulmadıklarını rapor etmişlerdir. Bizde çalışmamızda hemodinamik açıdan gruplar arasında belirgin bir fark bulamadık.…”

Section: Discussionunclassified

“…Magnezyumun preemptif etkinliği daha önce çalışılmış ve etkin olduğu gösterilmiştir. [6][7][8][9] Magnezyum vazodilatatör, antikonvülzan ve antiaritmik olarak kullanılmaktadır. Kalsiyum ve N-Metil-D-Aspartat (NMDA) reseptör antagonisti olarak etki etmekte ve katekolamin salınımını önlemektedir.…”

Section: Introductionunclassified

“…NMDA reseptör antagonistlerinin de santral sensitizasyona bağlı gelişen hiperaljezi ve allodiniyi, ayrı-ca postoperatif opioid gereksinimini azalttığı bildirilmiştir. [6][7][8]10] İntraoperatif remifentanil kullanımına bağlı gelişen hiperaljeziyi önlemede magnezyumun etkinliğinin değerlendirildiği bir çalışmaya rastlamadık. Bu nedenle bu çalışmada intraoperatif remifentanil kullanımına bağlı gelişen hiperaljeziyi önlemede operasyon öncesi uygulanan magnezyumun etkinliğini postoperatif ağrı skoru, opioid tüketimi ve cerrahi insizyon çevresindeki ağrı eşiğini algometre ve von Frey ile ölçerek değerlendirmeyi amaçladık.…”

Section: Introductionunclassified

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The role of magnesium in preventing postoperative hyperalgesia

Akarsu¹,

Tuncer²,

Reisli³

et al. 2012

Agri

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Section: Discussionunclassified

Section: Introductionunclassified

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The role of magnesium in preventing postoperative hyperalgesia

Akarsu¹,

Tuncer²,

Reisli³

et al. 2012

Agri

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show abstract

“…(Koinig, et al, 1998 differences in response to dextromethorphan, might ,) partially explain variations in pain perception.…”

Section: Oral Dextromethorphan Usage In Humansmentioning

confidence: 99%

A Comparison of the Effects of Preemptive Oral Dextromethorphan on Perceived Postoperative Pain in Male and Female Patients Undergoing Arthroscopic Knee Surgery

Eads¹,

Grieves²,

Peck³

et al. 2003

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Public reporting burden for this collection of information is estimated to average 1 f»ur per response, including the time for reviewing instnjctions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of inforhiation. Postoperative pain leads to increased morbidity, length of stay, and health care costs. Several studies have shown that preemptively administered N-methyl-D-aspartate (NMDA) antagonists, such as ketamine, are effective in decreasmg perception of postoperative pain. To date, there have not been any human studies to investigate a gender difference m NMDA receptor antagonism. The purpose of this study was to compare the gender differences in the effects of preemptive ketamine on perceived pain in males and females undergomg selected ENT surgical procedures. This prospective, double-blinded study compared perceived pain in male and female subjects drawn from a convenience sample of patients at a major military medical center. Ihs surgeries there patients were presenting for were tonsillectomy, adenoidectomy, tonsillectomy and adenoidectomy (T&A) and uvulopalatopharyngoplasty (UPPP). 41 subjects were randomly assigned to either a treatment group receiving .Img/kg ketimme or a control group receiving a placebo of .9% saline. The study drug was administered between induction and incision. Pain perception following surgery was measured using a Numeric Rating Scale (NRS) on arrival to the post anesthesia care unit (PACU), and at four subsequent data points (1, 4, 12, 24 hours after PACU arrival time). ANOVA and Friedman tests were used to analyze die NRS scores. The ANOVA test did not show a significant difference (p = .768) in postoperative pam perception between males and females who received preemptive ketamine. The Friedman test did not show a significant difference (p = .27) in the level of postoperative pain perception within the groups over the five data collection points.

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Formulation and Analgesic Effect of Sodium Hyaluronate and Magnesium Sulfate Combination in Rats Following Intra‐articular Injection

Lee

Jung

et al. 2017

Bulletin Korean Chem Soc

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The objective of this study was to formulate hyaluronate (HA) combined with magnesium sulfate (MS) for intra-articular (IA) injection, to provide rapid and profound analgesia in the treatment of osteoarthritis (OA). The injectable HA/MS combination was optimized with respect to the kinds and amounts of buffering agent (10 mM histidine, pH 7.0) and stabilizer (10 mM sodium citrate), by evaluating changes in the appearance, pH, and intrinsic viscosity at 60 C. Increasing concentrations of sodium citrate significantly inhibited the decline in intrinsic viscosity, denoting the depolymerization of HA, preserving over 91% of initial value. In an efficacy study in iodoacetate-induced OA rats, treatment with the HA/MS combination (1/2% w/v) significantly reduced joint swelling and pain, compared to the vehicle-and HA-treated groups (p < 0.05) at 7 days postdosing. Thus, IA administration of the combination of HA, a slow-acting symptom-modifying agent, with the inorganic analgesic is a potentially effective therapeutic approach for rapid pain relief in the OA knee.

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Magnesium Sulfate Reduces Intra- and Postoperative Analgesic Requirements

Abstract: The perioperative administration of i.v. magnesium sulfate reduces intra- and postoperative analgesic requirements in patients with almost identical levels of surgical stimulus. Our results demonstrate that magnesium can be an adjuvant to perioperative analgesic management.

Cited by 158 publications

References 13 publications

The role of magnesium in preventing postoperative hyperalgesia

The role of magnesium in preventing postoperative hyperalgesia

A Comparison of the Effects of Preemptive Oral Dextromethorphan on Perceived Postoperative Pain in Male and Female Patients Undergoing Arthroscopic Knee Surgery

Formulation and Analgesic Effect of Sodium Hyaluronate and Magnesium Sulfate Combination in Rats Following Intra‐articular Injection

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