Magnesium Sulfate Plus Lidocaine Reduces Propofol Injection Pain: A Double-blind, Randomized Study

Sun, Jiehao; Zhou, Riyong; Lin, Wendong; Zhou, Jiahao; Wang, Weijan

doi:10.1016/j.clinthera.2015.10.011

Cited by 13 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Several interventions have been advocated to alleviate the pain associated with propofol injection, which include addition of lignocaine, ketamine, 4 acetaminophen, 5 tramadol, 6 different doses of lidocaine, 7 and different concentrations of propofol 8 and topical nitroglycerin. 9 Other studies have suggested other methods for controlling pain, including the injection of low doses of narcotics such as sufentanil and butorphanol 10,11 injection in large vessels and lignocaine injection together with tourniquet closure, 12 cold or warm propofol, 13 metoclopramide injection as a premedication, 14 magnesium, 15 beta blocker, 16 midazolam, 17 5-HT3 receptor antagonists, 18 or Alpha-2 agonists like dexmedetomidine. 19…”

Section: Introductionmentioning

confidence: 99%

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Hossain¹,

Rashid²,

Babu³

et al. 2020

KYAMC j.

View full text Add to dashboard Cite

Background: Propofol is an intravenous (IV) anesthetic agent, can irritate the skin, mucous membrane and venous intima. The main drawback is the pain at injection site following its intravenous injection. Objectives: This study was performed to evaluate the effect of intravenous nitroglycerine on pain in patients following propofol injection. Materials and Methods: Eighty adult patients of both sexes, aged 20-50 years, according to American Society of Anesthesiologists (ASA) physical status were divided into two equal groups (n=40) to receive 200 mcg intravenous nitroglycerine diluted in 10 ml saline (group A) and 10 ml normal saline as placebo (group B) at an ambient operating room temperature in a randomized and double blinded fashion to compare the pain-relieving effects of the drugs during propofol injection before the patients lost consciousness. The pain on propofol injection was assessed according to the Mc Crirrick and Hunter scale. Results: The overall incidence and severity of pain were significantly less in Groups A (nitroglycerine group) than group B (placebo group) (p< 0.05). The incidence of mild and moderate pain in Group A versus group B was 25% vs 45% and 15% vs 30% respectively (p<0.05). The incidence of score '0' (no pain) was higher in Group A (60%) than Group B (25%) (p<0.05). Conclusion: Pretreatment with 200 mcg nitroglycerine with venous occlusion for one minute is effective pretreatment in alleviating propofol injection pain when compared to placebo. KYAMC Journal Vol. 10, No.-4, January 2020, Page 202-205

show abstract

Section: Introductionmentioning

confidence: 99%

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Hossain¹,

Rashid²,

Babu³

et al. 2020

KYAMC j.

View full text Add to dashboard Cite

show abstract

“…4 Many methods have been proposed to reduce the incidence of pain on propofol injection, including varying injection speed and carrier fluid, an adding other concomitant drugs, including the injection of low doses of narcotics such as pethidine, sufentanil and butorphanol, lignocaine injection together with tourniquet closure, coldwarm propofol, magnesium, beta blocker, 5-HT3 receptor antagonists, Alpha 2 agonists like dexmedetomidine. [5][6][7][8][9][10][11][12][13][14][15][16][17] Ketamine is a drug with analgesic effects, used in induction of anesthesia. It is an N-methyl-D-aspartate (NMDA) receptor antagonist with strong analgesic effects, even at low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Effect of Low Dose Ketamine on Propofol Injection Pain: A Double-Blind Clinical Trial

Hossain¹,

Rahman²,

Islam³

et al. 2020

KYAMC j.

View full text Add to dashboard Cite

Background: Propofol, most frequently used intravenous anesthetic for induction of routine elective surgical procedure. Pain on propofol injection (POPI) still remains a considerable concern for the anesthesiologist. A number of techniques has been tried to minimize propofol-induced pain with variable results. Objective: This study was performed to determine the effect of ketamine on reducing pain on propofol injection (POPI) at the onset of anesthesia. Materials and Methods: A total of 80 adult healthy patients were selected in this study of either sex, scheduled for routine elective ENT surgery under general anesthesia. The patients enrolled were divided randomly into two groups of 40 patients each. Group I (ketamine group) received 10 mg intravenous ketamine in 10 ml normal saline. Group II (placebo group) received 10 ml of 0.9% intravenous normal saline. Then the patients were induced with propofol and asked to report their pain during injection of propofol and recorded according to the Mc Cririck and Hunter scale. Results: The incidence of pain experienced in ketamine group was 10% patients and in saline group was 60% patients, which is statistically significant p<0.05. The severity of POPI was also lower in ketamine group than the saline group (p<0.05). The incidence of mild and moderate pain in ketamine group versus saline group was 7.5% versus 45% and 2.5% versus 15% respectively p<0.05. There was no severe pain recorded in any groups. Conclusion:Intravenous ketamine in low dose before induction of general anesthesia can be effective medication in reducing pain on propofol injection. KYAMC Journal Vol. 11, No.-2, July 2020, Page 96-99

show abstract

“…8 Other studies have suggested methods for controlling POPI, including the injection of low doses of narcotics such as sufentanil and butorphanol, 9,10 injection in large vessels, lignocaine injection together with tourniquet closure, 11 and cold-warm propofol. 12 Some researchers used magnesium, 13 beta blocker, 14 5-HT3 receptor antagonists, 15 Alpha 2 agonists like dexmedetomidine 3 and metoclopramide injection as a premedication for prevention of POPI.…”

Section: Introductionmentioning

confidence: 99%

Metoclopramide Pretreatment for Prevention of Pain on Propofol Injection: A Randomized Placebo-Controlled Study

Hossain¹,

Islam²,

Rahman³

et al. 2020

Delta Med Col J

View full text Add to dashboard Cite

Background: Propofol, the most frequently used intravenous anaesthetic, is used for induction, maintenance of anaesthesia and for sedation in patients scheduled for routine elective surgical procedure. Pain on propofol injection still remains a considerable concern for the anaesthesiologist. Objective: Aim of this study was to observe the efficacy of metoclopramide as pretreatment for the prevention of pain caused by the propofol injection in patients undergoing elective surgery under general anaesthesia. Materials and method: A total of 80 patients were taken up in the study in the age group of 20 to 50 years of either sex, ASA grade I/II, scheduled for routine elective surgical procedure under general anesthesia with endotracheal intubation and using propofol as induction agent. The patients enrolled were divided randomly into two groups of 40 patients each. Group A received 10 mg metoclopramide IV diluted in 5 ml saline. Group B received 5 ml of normal saline as placebo before propofol injection. The patients were asked to report their pain according to the scale provided to them in the form of none, mild, moderate and severe after injection of propofol. Results: The overall incidence and severity of pain were significantly less in Group A (metoclopramide group) than in group B (placebo group) (p< 0.05). The incidence of mild and moderate pain in Group A versus group B was 15% vs 45% and 5% vs 25% respectively (p<0.05). The incidence of score '0' (no pain) was higher in Group A (80%) thanGroup B (25%) (p< 0.05). Conclusion: Intravenous metoclopramide is effective for relief of pain on propofol injection without any significant side effects.

show abstract

Magnesium Sulfate Plus Lidocaine Reduces Propofol Injection Pain: A Double-blind, Randomized Study

Cited by 13 publications

References 30 publications

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

Effect of Low Dose Ketamine on Propofol Injection Pain: A Double-Blind Clinical Trial

Metoclopramide Pretreatment for Prevention of Pain on Propofol Injection: A Randomized Placebo-Controlled Study

Contact Info

Product

Resources

About