Magnesium sulfate in the treatment of refractory ventricular fibrillation in the prehospital setting

Allegra, J.R.; Lavery, Robert F.; Cody, Ronald P.; Birnbaum, Glen; Brennan, John A.; Hartman, Anthony; Horowitz, M.; Nashed, Ash; Yablonski, Michael E.

doi:10.1016/s0300-9572(00)00375-0

Cited by 106 publications

(48 citation statements)

References 21 publications

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“…In 3 randomized clinical trials, magnesium was not found to increase rates of ROSC for cardiac arrest due to any presenting rhythm, 105 including VF/pVT. 106,107 In these RCTs and in 1 additional randomized clinical trial, the use of magnesium in cardiac arrest for any rhythm presentation of cardiac arrest 105,108 or strictly for VF arrest 106,107 did not improve survival to hospital discharge or neurologic outcome.…”

Section: Magnesiummentioning

confidence: 82%

Part 7: Adult Advanced Cardiovascular Life Support

Link¹,

Berkow²,

Kudenchuk³

et al. 2015

Circulation

1,031

429

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Section: Magnesiummentioning

confidence: 82%

Part 7: Adult Advanced Cardiovascular Life Support

Link¹,

Berkow²,

Kudenchuk³

et al. 2015

Circulation

1,031

429

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“…There is insufficient evidence to recommend for or against the routine administration of magnesium during cardiac arrest. [231][232][233] Precautions Magnesium produces vasodilation and may cause hypotension if administered rapidly.…”

Section: Magnesiummentioning

confidence: 99%

Part 14: Pediatric Advanced Life Support

Kleinman¹,

Chameides²,

Schexnayder³

et al. 2010

Circulation

907

304

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“…In the case of Allegra et al . [14], a multicenter prehospital study clinical trial conducted in New Jersey, USA. was found.…”

Section: Resultsmentioning

confidence: 99%

Antiarrhythmia drugs for cardiac arrest: a systemic review and meta-analysis

Huang

Yang

et al. 2013

Critical Care

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IntroductionAntiarrhythmia agents have been used in the treatment of cardiac arrest, and we aimed to review the relevant clinical controlled trials to assess the effects of antiarrhythmics during cardiopulmonary resuscitation.MethodsWe searched databases including Cochrane Central Register of Controlled Trials; MEDLINE, and EMBASE. Clinical controlled trials that addressed the effects of antiarrhythmics (including amiodarone, lidocaine, magnesium, and other new potassium-channel blockers) on the outcomes of cardiac arrest were included. Data were collected independently by two authors. The risk ratio of each outcome was collected, and meta-analysis was used for data synthesis if appropriate. Heterogeneity was assessed with the χ2 test and the I2 test.ResultsTen randomized controlled trials and seven observational trials were identified. Amiodarone (relative risk (RR), 0.82; 95% confidence interval (CI), 0.54 to 1.24), lidocaine (RR, 2.26; 95% CI, 0.93to 5.52), magnesium (RR, 0.82; 95% CI, 0.54 to 1.24) and nifekalant were not shown to improve the survival to hospital discharge compared with placebo, but amiodarone, lidocaine, and nifekalant were shown to be beneficial to initial resuscitation, assessed by the rate of return of spontaneous circulation and survival to hospital admission, with amiodarone being superior to lidocaine (RR, 1.28; 95% CI, 0.57 to 2.86) and nifekalant (RR, 0.50; 95% CI, 0.19 to 1.31). Bretylium and sotalol were not shown to be beneficial.ConclusionsOur review suggests that when administered during resuscitation, antiarrhythmia agents might not improve the survival to hospital discharge, but they might be beneficial to initial resuscitation. This is consistent with the AHA 2010 guidelines for resuscitation and cardiovascular emergency, but more studies with good methodologic quality and large numbers of patients are still needed to make further assessment.

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Magnesium sulfate in the treatment of refractory ventricular fibrillation in the prehospital setting

Cited by 106 publications

References 21 publications

Part 7: Adult Advanced Cardiovascular Life Support

Part 7: Adult Advanced Cardiovascular Life Support

Part 14: Pediatric Advanced Life Support

Antiarrhythmia drugs for cardiac arrest: a systemic review and meta-analysis

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