Magnesium Sulfate Combined with Nifedipine Is Effective in Pregnancy-Induced Hypertension and Reduces Levels of Serum β2- Microglobulin and Retinol Binding Protein 4

Song, Jie; Lan, Ruihong; Gong, Huiyu; Zheng, Lei; Yang, Yang; Yi, Dahua; Hu, Enze

doi:10.18502/ijph.v48i12.3569

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“…It was suggested that the combination of nifedipine tablets and magnesium sulfate was effective in improving hypercoagulability in patients with pregnancy-induced hypertension, and was more effective than magnesium sulfate alone. SONG ( 13 ) and others have confirmed that nifedipine combined with magnesium sulfate has a good therapeutic effect on patients with pregnancy-induced hypertension, and the clinical effect is significant.…”

Section: Discussionmentioning

confidence: 89%

Effects of Nifedipine Tablets Combined With Magnesium Sulfate on Blood Coagulation Index, Oxidative Stress, NO and ET-1 Levels in Patients With Pregnancy Hypertension

Zhang

2022

Front. Surg.

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ObjectiveTo explore the effects of nifedipine tablets combined with magnesium sulfate on blood coagulation indexes, oxidative stress and levels of NO and ET-1 in patients with Pregnancy-induced hypertension syndrome (PIH).MethodsA total of 110 patients with hypertension during pregnancy were admitted to our hospital from January 2020 to January 2021. According to the random number table method, 110 patients were divided into the control group and the therapy group, with 55 cases in each group. The blood pressure levels (systolic and diastolic blood pressure), coagulation indexes (TT, PT, APTT, Fib), oxidative stress indexes (LPO, MDA, SOD), vascular endothelial function (ET-1, NO), clinical efficacy and adverse reactions of the two groups were compared.ResultsAfter therapy, the systolic blood pressure and diastolic blood pressure of the two groups were significantly decreased, and the therapy group was significantly lower than the control group (P < 0.05). After therapy, PT, TT, and APTT in two groups were significantly increased, and Fib was significantly decreased, and PT, TT, APTT in the therapy group were higher than those in the control group, and Fib was lower than that in the control group (P < 0.05). After therapy, LPO and MDA in two groups were significantly decreased, and SOD was significantly increased, and LPO and MDA in the therapy group were lower than those in the control group, and SOD was higher than that in the control group (P < 0.05). After therapy, ET-1 in two groups were significantly increased, and NO and ET-1/NO was significantly decreased, and ET-1 in the therapy group was higher than that in the control group, and NO and ET-1/NO were lower those in the control group (P < 0.05). The total clinical effective rate of patients in the therapy group was 94.5%, and in the control group was 81.8%, the therapy group was significantly better than the control group (P < 0.05). The total incidence of adverse reactions in the therapy group was 7.3%, and in the control group was 21.8%, the therapy group was significantly lower than the control group (P < 0.05).ConclusionNifedipine tablets combined with magnesium sulfate in the treatment of PIH can improve the blood coagulation function of patients, reduce oxidative stress damage, adjust the serum levels of ET-1 and NO, and improve the clinical efficacy.

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Section: Discussionmentioning

confidence: 89%