Magnesium-substituted hydroxyapatite

Omema, Ume; Khalid, Hamad; Chaudhry, Aqif Anwar

doi:10.1016/b978-0-08-102834-6.00008-2

Cited by 2 publications

(5 citation statements)

References 57 publications

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“…The (Ca + Zn)/P, (Ca + Mg)/P and Ca/(P + Si) ratio was maintained at 1.67 as given in Table 1. Zn-HA, Mg-HA, and Si-HA powders were prepared based on the chemical formulae Ca 10−x (xZn(NO 3 )•6H 2 O•PO 4 ) 6 (OH) 2 , Ca 10−x (xMg(NO 3 )•6H 2 O(PO 4 ) 6 (OH) 2 and Ca 10 (PO 4 ) 6−x (SiO 4 )x(OH) 2−x , respectively as proposed earlier [37][38][39]. A pure HA was synthesized initially by using a microwave irradiation technique as described earlier by our group [40].…”

Section: Synthesis Of Substituted Hamentioning

confidence: 99%

Low-Cost Deposition of Antibacterial Ion-Substituted Hydroxyapatite Coatings onto 316L Stainless Steel for Biomedical and Dental Applications

Khan

Awais

2020

Coatings

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Substitutions of ions into an apatitic lattice may result in antibacterial properties. In this study, magnesium (Mg)-, zinc (Zn)-, and silicon (Si)-substituted hydroxyapatite (HA) were synthesized using a microwave irradiation technique. Polyvinyl alcohol (PVA) was added during the synthesis of the substituted HA as a binding agent. The synthesized Mg-, Zn-, and Si-substituted HAs were then coated onto a 316L-grade stainless-steel substrate using low-cost electrophoretic deposition (EPD), thereby avoiding exposure to high temperatures. The deposited layer thickness was measured and the structural, phase and morphological analysis were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscope (SEM), respectively. The bacterial adhesion of Staphylococcus aureus was characterized at 30 min, 2 h and 6 h. The results showed homogeneous, uniform thickness (50–70 µm) of the substrate. FTIR and XRD showed the characteristic spectral peaks of HA, where the presence of Mg, Zn and Si changed the spectral peak intensities. The Mg–HA coating showed the least bacterial adhesion at 30 min and 2 h. In contrast, the Si–HA coating showed the least adhesion at 6 h. EPD showed an effective way to get a uniform coating on bio-grade metal implants, where ionic-substituted HA appeared as alternative coating material compared to conventional HA and showed the least bacterial adhesion.

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Section: Synthesis Of Substituted Hamentioning

confidence: 99%

Low-Cost Deposition of Antibacterial Ion-Substituted Hydroxyapatite Coatings onto 316L Stainless Steel for Biomedical and Dental Applications

Khan

Awais

2020

Coatings

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“…Hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) is the thermodynamically most stable calcium phosphate (CaP) phase and is often considered the most similar among different CaPs to the mineral component of vertebrate's hard tissues [1]. In addition, HAP has excellent cytocompatibility and osteoconductivity, making it one of the most investigated materials in bone tissue engineering [2][3][4]. However, the mineral component of hard tissues, so-called biological apatite, is non-stoichiometric, poorly crystalline, ion-substituted hydroxyapatite [1,2,5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, HAP has excellent cytocompatibility and osteoconductivity, making it one of the most investigated materials in bone tissue engineering [2][3][4]. However, the mineral component of hard tissues, so-called biological apatite, is non-stoichiometric, poorly crystalline, ion-substituted hydroxyapatite [1,2,5]. Due to the specific biological roles that substitute ions have in bone metabolism, introducing substitute ions into HAP structure attracts increased attention as a way of increasing its bioactivity [2,[6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…However, the mineral component of hard tissues, so-called biological apatite, is non-stoichiometric, poorly crystalline, ion-substituted hydroxyapatite [1,2,5]. Due to the specific biological roles that substitute ions have in bone metabolism, introducing substitute ions into HAP structure attracts increased attention as a way of increasing its bioactivity [2,[6][7][8][9]. The crystal structure of stoichiometric HAP allows for several different anions and cations to be used as substitutions [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…It plays a key role in bone metabolism since it influences osteoblast and osteoclast activity, and thereby bone growth. Moreover, a lack of magnesium is associated with decreased osteoblast activity, bone fragility, and osteoporosis [2,[13][14][15]. Simultaneously, it is beneficial in processes like cell proliferation and differentiation, as well as osteoconductivity and resorption [2].…”

Section: Introductionmentioning

confidence: 99%

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A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing

et al. 2022

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To assess the application potential of novel biomaterials, their behaviour in model media and upon sterilization should be investigated, as well as the stability related to their storage conditions. Such data are lacking for Mg-substituted HAP (Mg-HAP). Therefore, the changes in the local structure of non-substituted and Mg-HAP after irradiation and immersion in corrected simulated fluid and saline solution for 28 days were followed by electron paramagnetic resonance (EPR) spectroscopy for the first time. To better understand the stability of radical species induced by sterilization, EPR spectra of samples kept for 2 h at temperatures up to 373 K were recorded to provide an insight into the stability of the sample storage conditions by the accelerated aging method. Samples were characterized by PXRD, FTIR, SEM, EDS, AAS and TGA. Results confirmed that irradiation does not induce changes in the composition or the structure of any of the investigated materials. Fading or the complete disappearance of radical signals in the EPR spectra after immersion in both media was accompanied by the disappearance of other phases formed as a minor byproduct in the synthesis of substituted HAP, as confirmed by PXRD and FTIR analysis. Obtained results confirm the great potential of Mg-HAPs for biomedical applications, although closer attention should be given to the processes related to sample storage stability at different temperatures.

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Magnesium-substituted hydroxyapatite

Cited by 2 publications

References 57 publications

Low-Cost Deposition of Antibacterial Ion-Substituted Hydroxyapatite Coatings onto 316L Stainless Steel for Biomedical and Dental Applications

Low-Cost Deposition of Antibacterial Ion-Substituted Hydroxyapatite Coatings onto 316L Stainless Steel for Biomedical and Dental Applications

A Comparative EPR Study of Non-Substituted and Mg-Substituted Hydroxyapatite Behaviour in Model Media and during Accelerated Ageing

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