Magnesium Regulates the Circadian Oscillator in Cyanobacteria

Jeong, Young M.; Dias, Cristiano L.; Diekman, Casey O.; Brochon, Helene; Kim, Pyonghwa; Kaur, Manpreet; Kim, Yong‐Sung; Jang, Hye In; Kim, Yong Ick

doi:10.1177/0748730419851655

Cited by 23 publications

(27 citation statements)

References 32 publications

(52 reference statements)

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“…Daily magnesium fluxes are thought to regulate cellular timekeeping and energy balance [37]. Intracellular magnesium concentration acts as a cell-autonomous timekeeping component to determine key clock properties in human cell lines and unicellular alga [38]. In addition, magnesium has an essential role in ion transport and electrical conductivity, which facilitate N-methyl-D-aspartic acid (NMDA) receptor function, an important sleep regulator [36].…”

Section: Discussionmentioning

confidence: 99%

Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005–2016

Ikonte¹,

Mun²,

Reider³

et al. 2019

Nutrients

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One third of U.S. adults report short sleep (<7 h), which has been linked to negative health outcomes. Inadequate intake of micronutrients across the U.S. adult population has been reported, and a relationship between sleep conditions and micronutrient intake is emerging. This cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES 2005–2016) (n = 26,211) showed that participants with short sleep duration had a lower usual intake (Food + Supplements) of calcium, magnesium, and vitamin D in all adults aged 19+ years, and vitamin K in adults aged 19–50 years, even after adjusting for covariates. In addition, participants reporting short sleep had a higher percentage of individuals with intake lower than the estimated average requirement (EAR) across multiple nutrients. Age and gender differences were observed in the prevalence of inadequate intake across multiple nutrients. Adults aged 51–99 years with short sleep duration had inadequate intake with respect to more nutrients. In females there was an association between short sleep and a higher prevalence of inadequate intake (Food + Spp) for calcium, magnesium, and vitamins A, C, D, E, and K (above adequate intake). Conversely, males reporting short sleep only had an inadequate intake of vitamin D. Overall, we demonstrate that short sleep is associated with increased nutrient inadequacy, emphasizing the possible need for dietary supplementation.

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Section: Discussionmentioning

confidence: 99%

Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005–2016

Ikonte¹,

Mun²,

Reider³

et al. 2019

Nutrients

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“…Previously, we suggested that altering the magnesium concentration may be a signal for entrainment of the circadian clock (Jeong et al, 2019). To determine whether the magnesium concentration changes in response to light and dark in cyanobacteria, we measured the total magnesium concentration through ICP-MS.…”

Section: Magnesium Ion Is Not Used As a Signal For Entrainment In Cyamentioning

confidence: 99%

“…The phosphorylation state of KaiC oscillates with a circadian period, and the structural basis of the mechanism is well known (Tseng et al, 2014;Tseng et al, 2017). KaiA and KaiB activate the autophosphorylation and autodephosphorylation of KaiC, respectively, by changing the A-loop conformation and the binding affinity of magnesium in KaiC (Chang et al, 2015;Jeong et al, 2019;Kim et al, 2008). These antagonistic interactions generate the rhythm of KaiC phosphorylation with a nearly 24-h period (Akiyama et al, 2008).…”

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confidence: 99%

CikA, an Input Pathway Component, Senses the Oxidized Quinone Signal to Generate Phase Delays in the Cyanobacterial Circadian Clock

et al. 2020

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The circadian clock is a timekeeping system in most organisms that keeps track of the time of day. The rhythm generated by the circadian oscillator must be constantly synchronized with the environmental day/night cycle to make the timekeeping system truly advantageous. In the cyanobacterial circadian clock, quinone is a biological signaling molecule used for entraining and fine-tuning the oscillator, a process in which the external signals are transduced into biological metabolites that adjust the phase of the circadian oscillation. Among the clock proteins, the pseudo-receiver domain of KaiA and CikA can sense external cues by detecting the oxidation state of quinone, a metabolite that reflects the light/dark cycle, although the molecular mechanism is not fully understood. Here, we show the antagonistic phase shifts produced by the quinone sensing of KaiA and CikA. We introduced a new cyanobacterial circadian clock mixture that includes an input component in vitro. KaiA and CikA cause phase advances and delays, respectively, in this circadian clock mixture in response to the quinone signal. In the entrainment process, oxidized quinone modulates the functions of KaiA and CikA, which dominate alternatively at day and night in the cell. This in turn changes the phosphorylation state of KaiC—the central oscillator in cyanobacteria—ensuring full synchronization of the circadian clock. Moreover, we reemphasize the mechanistic input functionality of CikA, contrary to other reports that focus only on its output action.

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“…The association of magnesium with sleep has been explored by other investigators [20,51]. Magnesium appears to have a role in sleep-wake cycles and act as a cell-autonomous timekeeping component [62,63]. It also plays a role in melatonin synthesis [64].…”

Section: Previous Studiesmentioning

confidence: 99%

Dietary Approaches to Stop Hypertension (DASH) Score and Its Association with Sleep Quality in a National Survey of Middle-Aged and Older Men and Women

et al. 2020

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Complex processes appear to link sleep duration and quality with dietary patterns. Numerous studies show healthful benefits of the Dietary Approaches to Stop Hypertension (DASH) diet, but few have examined its association with sleep duration or quality. The current study tested cross-sectional associations of DASH diet quality score with sleep quality among adults. Analyses of participants were from the 2005–2008 wave of the National Health and Nutrition Examination Surveys (n = 3941 adults ≥30 years of age, complete data). We performed sex- and age group-stratified multiple OLS regression analyses with DASH total score and components as main predictors and sleep quality as main outcomes, adjusting sequentially for socio-demographic, behavioral and health-related factors. Sex and age differences in associations of DASH with sleep quality, adjusting for covariates, were also examined by incorporating two-way interaction terms between sex/age and the DASH score in each unstratified model. We found that the DASH diet score was inversely related to poor sleep-related daytime dysfunction adjusted by age, sex, demographic and socio-economic factors. Some sex-specific associations were detected between DASH diet component scores and sleep quality. Notably, the potassium DASH component was inversely associated with Factor 1 (“sleepiness and sleep disturbance”) among women. The fiber DASH component was associated with better sleep quality and inversely related to Factor 2 (“sleep-related daytime dysfunction”) in younger subjects. This study indicates health benefits of the DASH diet for sleep duration and quality. Future longitudinal studies and randomized placebo-controlled trials are required to ascertain protective effects.

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Magnesium Regulates the Circadian Oscillator in Cyanobacteria

Cited by 23 publications

References 32 publications

Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005–2016

Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005–2016

CikA, an Input Pathway Component, Senses the Oxidized Quinone Signal to Generate Phase Delays in the Cyanobacterial Circadian Clock

Dietary Approaches to Stop Hypertension (DASH) Score and Its Association with Sleep Quality in a National Survey of Middle-Aged and Older Men and Women

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