Magnesium oxide nanotube as novel strategies to enhance the anticancer activity of 5-Fluorouracil

Chen, Kejun; Abdtawfeeq, Tarik Hafdhi; Kadhim, Iman K.; Jawad, Mohammed Abed; Hammad, Mohamed; Mohammed, Naseer Mihdi; Riadi, Yassine; Hadrawi, Salema K.; Kaur, Jupinder; Soltani, Alireza

doi:10.1016/j.molliq.2023.122214

Cited by 9 publications

(1 citation statement)

References 45 publications

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“…Chen and co-researchers [182] proposed a functionalized magnesium oxide nanotube adsorbed with 5-Fluorouracil and studied its anticancer efficiency towards breast cancer cell lines (HER2 and EGFR). The as-proposed novel nanostructure presented enhanced inhibitory effects against both breast cancer cell types, illustrating that this complex could be promising for the fabrication of novel anticancer agents to treat breast cancer patients.…”

Section: Anticancer Activitymentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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Section: Anticancer Activitymentioning

confidence: 99%