Magnesium metabolism in health and disease

Musso, Carlos G.

doi:10.1007/s11255-009-9548-7

Cited by 180 publications

(136 citation statements)

References 28 publications

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“…Mustering and handling of cattle for collection of blood or urine samples may precipitate grass tetany in susceptible cows, and may be impractical when many cows in the mob have young calves at foot. In human medicine, subclinical hypomagnesaemia is associated with diabetes, metabolic syndrome and cardiovascular disease [82,83], and may also have a negative impact on the ability to cope with hypocalcaemia, since adequate magnesium level is important for both the excretion of parathyroid hormone [84] and the tissue responsiveness to parathyroid hormone [85].…”

Section: Diagnosing Grass Tetanymentioning

confidence: 99%

Hypomagnesemia Tetany in Cattle

Zelal¹

2017

J Adv Dairy Res

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Grass tetany, sometimes called grass staggers or hypomagnesemia, can be a serious problem in Syria with cattle grazing small grain or ryegrass pastures. hypomagnesemia tetany has been known under a variety of names, including magnesium tetany, lactation tetany and grass staggers, but most of these terms have been discarded because the disease is not always associated with lactation or with grazing animals.The exact cause of hypomagnesemia tetany in ruminant animals is a dietary deficiency of magnesium that may be a contributory factor. Some research workers consider the condition to be caused by a cation-anion imbalance in the diet, and Some research workers believe that high intake of the element (K & Na) may interfere with the absorption and metabolism of magnesium in the animal, which may be an important factor in the etiology of hypomagnesemia tetany.Although the exact cause of hypomagnesemia is still uncertain, the primary factor would appear to be inadequate absorption of magnesium from the digestive tract. A high degree of success in preventing hypomagnesemia may be obtained by increasing the magnesium intake. This can be effected by feeding with magnesium rich mineral mixtures or, alternatively, by increasing the magnesium content of pasture by the application of magnesium fertilizers.

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Section: Diagnosing Grass Tetanymentioning

confidence: 99%

Hypomagnesemia Tetany in Cattle

Zelal¹

2017

J Adv Dairy Res

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“…Magnesium, being the second abundant intracellular caution and its involvement in more than 300 enzymatic reactions, has been studied for its relation with insulin resistance and inflammation 1 . In the present study, insulin resistance, and insulin levels were higher and insulin sensitivity was lower in subject with hypomagnesaemia as compared to subjects with normal serum magnesium levels.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced intracellular magnesium concentrations result in a defective tyrosine-kinase activity, post-receptor impairment in insulin action, and worsening of insulin resistance in diabetic patients 1 . It was observed that autophosphorylation of the beta-subunit of the insulin receptor was significantly reduced by 50% in magnesium-deficient rats and the tyrosine kinase activity of insulin receptors by hypomagnesaemia 35 .…”

Section: Discussionmentioning

confidence: 99%

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Relation of magnesium with insulin resistance and inflammatory markers in subjects with known Coronary artery disease

Mahalle¹,

Mk²,

Kulkarni³

et al. 2014

J Cardiovasc. Dis. Res.

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INTRODUCTIONMagnesium is the second most abundant intracellular cation and is an essential element that has numerous biological functions. Magnesium is plentiful in green leafy, cereal, grain, nuts and legumes, however, refining or processing of food may deplete magnesium content by nearly 85% 1 . About 30% of ingested magnesium is absorbed by distal small intestine. Magnesium acts as a cofactor in many of enzymatic reactions in the human body. Magnesium is essential for the synthesis of nucleic acids and proteins, for intermediary metabolism particularly related to the neuromuscular and cardiovascular systems. Over 300 enzymes are dependent on magnesium. Magnesium influences the enzymatic activity by binding to legends such as ATP in ATP-requiring enzymes, enolase, pyruvate kinase, and pyrophosphatase, leading to conformational change during ABSTRACT Background: Magnesium plays an important role in regulating insulin action and secretion. Dietary magnesium deficiency and hypomagnesemia have been associated with inflammation. There is paucity of data regarding this in Indian subjects. Hence, we studied the relation of serum and dietary magnesium with insulin resistance (IR) and inflammatory markers. Methods & Results:We studied the relation of serum high sensitive C-Reactive Protein (hsCRP), interlukin-6 (IL-6) and tumor Necrosis Factor (TNF-α) with cardiovascular risk factors in three hundred coronary artery disease patients. Nutrition assessment was done at the time of recruitment. Patients were evaluated for anthropometry, cardiovascular risk factors, and blood samples were collected. Patients were divided into three groups according to serum magnesium levels; ≤1.6 (Group 1), >1.6-2.6 (Group 2) and: >2.6 mg/dl (Group 3) and into two groups according to recommended dietary allowance (RDA) for magnesium (≤350 mg/day and >350 mg/day). More than half of patients (58.6%) were having hypomagnesemia and 62% were consuming magnesium below RDA. Insulin and IR was significantly higher and insulin sensitivity was significantly lower in group 1 compared to group 2 and 3. Insulin and IR was correlated negatively; and insulin sensitivity was correlated positively with serum magnesium. Similarly inflammatory markers were significantly higher in group1 when compared with group 2 and 3 and they were correlated negatively with serum magnesium. Dietary magnesium was positively correlated with serum magnesium. Insulin and IR were significantly higher and insulin sensitivity was significantly lower in subjects with low RDA for magnesium. Insulin and IR were correlated negatively and sensitivity was correlated positively with dietary magnesium. Inflammatory markers; IL-6, TNF-α, and hs CRP were significantly high in subjects with low RDA for magnesium and were correlated negatively with dietary magnesium. Conclusion: Hypomagnesemia and low dietary magnesium is associated with IR and inflammatory markers in patients with coronary artery disease.

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“…Excess magnesium from food does not pose a risk to the health of a healthy person because the kidneys expell excess magnesium in the urine (Musso, 2009). …”

Section: Introductionmentioning

confidence: 99%

Gravimetric Analysis of Magnesium in Pharmaceutical Substances

Marjanović-Balabań

Jelić

Antunović

et al. 2013

QOL

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Summary:The aim of this study was to determine the content of magnesium in magnesium-chloride and magnesium-sulfate using the gravimetric analysis method, and to do the comparison of experimental results with calculations, stoichiometric calculation. Magnesium is one of the least present minerals in the soil and that is why, even in a wellbalanced diet, a lack of magnesium is present. It is of great importance for the human body and is increasingly consumed using different nutritional supplements. Magnesium-chloride is one of the best forms for the compensation magnesium in the body, because the body absorbs it the best.

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Magnesium metabolism in health and disease

Cited by 180 publications

References 28 publications

Hypomagnesemia Tetany in Cattle

Hypomagnesemia Tetany in Cattle

Relation of magnesium with insulin resistance and inflammatory markers in subjects with known Coronary artery disease

Gravimetric Analysis of Magnesium in Pharmaceutical Substances

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