Magnesium Metabolism

Wacker, Warren E. C.; Vallée, Bert L.

doi:10.1056/nejm195808282590906

Cited by 106 publications

(12 citation statements)

References 96 publications

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“…Some of the peptidases, including leucine aminopeptidase, which has been shown to be present in pancreatic juice (Christodoulopoulos et al, 1961), require magnesium as a cofactor (Wacker and Vallee, 1958). The finding that changes in magnesium concentration resembled but did not always parallel changes in calcium concentration suggests a different secretory origin of this ion.…”

Section: Discussionmentioning

confidence: 99%

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

Nakajima¹

1973

Gut

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SUMMARY The effect of the C-terminal octapeptide of cholecystokinin-pancreozymin (CCK-PZ), caerulein, and the C-terminal tetrapeptide of gastrin on pancreatic secretion of fluid, electrolyte, amylase, and protein was studied in anaesthetized dogs prepared with pancreatic fistulae. Against background stimulation of fluid secretion with submaximal doses of secretin, all the polypeptides produced a qualitatively similar pancreatic response, causing a highly significant increase in amylase, protein, calcium, and zinc concentrations. Magnesium concentration was significantly increased only when the concentration preceding the administration of the peptide was below 100 ,u-equiv/l. Octa-CCK-PZ was 13-35 times and 20-56 times more potent than tetragastrin on weight and molar bases, respectively, as a stimulant of amylase secretion. The threshold doses were largest for amylase, lower for calcium, and lowest for zinc. A significant linear correlation was observed between amylase and calcium concentration, zinc and protein concentration, and magnesium and calcium concentration. The peptides produced some increase in secretin-induced volume flow, whereas bicarbonate, chloride, sodium, and potassium concentrations remained unchanged. The direct relation between bicarbonate concentration and flow rate was limited to rates below 1.5 ml/5 minutes. At higher rates bicarbonate and chloride concentration reached a high and low plateau, respectively, although the first five-min sample of pancreatic juice after secretin stimulation exhibited a relatively low bicarbonate and high chloride concentration compared with its voluminous flow. Chloride concentration varied inversely with bicarbonate concentration, the sum of the two anions being constant.The intestinal hormone cholecystokinin/pancreozymin (CCK-PZ), for which a partial structure has been proposed, is a single-chain polypeptide with 33 amino acid residues (Mutt and Jorpes, 1968). The C-terminal pentapeptide of CCK-PZ is structurally identical with that of the gastric hormone gastrin, and also of the decapeptide caerulein, isolated from the skin of Hyla caerulea (Anastasi, Erspamer, and Endean, 1968). Recently Plusec, Sheehan, Sabo, Williams, Kocy, and Ondetti (1970) have synthesized the C-terminal octapeptide of CCK-PZ (octa CCK-PZ) which possesses the biological activities of the full hormonal molecule.It has been demonstrated that octa CCK-PZ is more potent, on weight and molar bases, than the 'Address for correspondence: Sumio Nakajima, MD, 2nd

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Section: Discussionmentioning

confidence: 99%

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

Nakajima¹

1973

Gut

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“…Stutzman and Amatuzio (1953) stressed the importance of hepatic cirrhosis as a cause of hypomagnesaemia. Since then, additional information on hypomagnesaemia in this condition has been provided by Flink (1956), Flink, McCollister, Prasad, Melby, and Doe (1957), Wacker and Vallee (1958), and Hanze (1962). As themainpathological lesion of the liver in prolonged cases of CBA is biliary cirrhosis, a low serum magnesium level is presumed to reflect the biliary cirrhosis.…”

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confidence: 99%

Serum magnesium level in infants and children with hepatic diseases.

Kobayashi¹,

Shiraki²

1967

Archives of Disease in Childhood

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“…In the past, reluctance to determine the serum magnesium level in the newborn infant has been due in part to the relative unreliability of methods hitherto employed (Wacker and Vallee, 1958), and the need for large amounts of blood, particularly where repeat determinations are proposed.…”

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confidence: 99%